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- HAND_domain abstract "In molecular biology, the HAND domain is a protein domain which adopts a secondary structure consisting of four alpha helices, three of which (H2, H3, H4) form an L-like configuration. Helix H2 runs antiparallel to helices H3 and H4, packing closely against helix H4, whilst helix H1 reposes in the concave surface formed by these three helices and runs perpendicular to them. This domain confers DNA and nucleosome binding properties to the proteins in which it occurs. It is named the HAND domain because its 4-helical structure resembles an open hand.HAND domain-containing proteins include proteins involved in nucleosome remodelling, an energy-dependent process that alters histone-DNA interactions within nucleosomes, thereby rendering nucleosomal DNA accessible to regulatory factors. The ATPases involved in nucleosome remodelling belong to the SWI2/SNF2 subfamily of DEAD/H-helicases, which contain a conserved ATPase domain characterised by seven motifs. Proteins within this family differ with regard to domain organisation, their associated proteins and the remodelling complex in which they reside. The ATPase ISWI is a member of this family. ISWI can be divided into two regions: an N-terminal region that contains the SWI2/SNF2 ATPase domain, and a C-terminal region that is responsible for substrate recognition. The C-terminal region contains 12 alpha-helices and can be divided into three domains and a spacer region: a HAND domain, a SANT domain (c-Myb DNA-binding like), a spacer helix, and a SLIDE domain (SANT-like but with several insertions).".
- HAND_domain symbol "HAND".
- HAND_domain thumbnail PDB_1ofc_EBI.jpg?width=300.
- HAND_domain wikiPageID "33398335".
- HAND_domain wikiPageLength "2696".
- HAND_domain wikiPageOutDegree "27".
- HAND_domain wikiPageRevisionID "591575425".
- HAND_domain wikiPageWikiLink ATPase.
- HAND_domain wikiPageWikiLink ATPases.
- HAND_domain wikiPageWikiLink Alpha_helices.
- HAND_domain wikiPageWikiLink Alpha_helix.
- HAND_domain wikiPageWikiLink Antiparallel_(biochemistry).
- HAND_domain wikiPageWikiLink Biomolecular_structure.
- HAND_domain wikiPageWikiLink Category:Protein_domains.
- HAND_domain wikiPageWikiLink Conserved_sequence.
- HAND_domain wikiPageWikiLink DEAD_box.
- HAND_domain wikiPageWikiLink DNA.
- HAND_domain wikiPageWikiLink Enzyme_substrate.
- HAND_domain wikiPageWikiLink Gene_regulation.
- HAND_domain wikiPageWikiLink Helicase.
- HAND_domain wikiPageWikiLink Histone.
- HAND_domain wikiPageWikiLink Multiprotein_complex.
- HAND_domain wikiPageWikiLink N-terminal.
- HAND_domain wikiPageWikiLink N-terminus.
- HAND_domain wikiPageWikiLink Nucleosome.
- HAND_domain wikiPageWikiLink Protein.
- HAND_domain wikiPageWikiLink Protein_complex.
- HAND_domain wikiPageWikiLink Protein_domain.
- HAND_domain wikiPageWikiLink Protein_motif.
- HAND_domain wikiPageWikiLink Proteins.
- HAND_domain wikiPageWikiLink Regulation_of_gene_expression.
- HAND_domain wikiPageWikiLink SANT_domain.
- HAND_domain wikiPageWikiLink SLIDE_domain.
- HAND_domain wikiPageWikiLink Secondary_structure.
- HAND_domain wikiPageWikiLink Structural_motif.
- HAND_domain wikiPageWikiLink Substrate_(chemistry).
- HAND_domain caption "nucleosome recognition module of iswi atpase".
- HAND_domain hasPhotoCollection HAND_domain.
- HAND_domain interpro "IPR015194".
- HAND_domain name "HAND".
- HAND_domain pfam "PF09110".
- HAND_domain scop "1".
- HAND_domain symbol "HAND".
- HAND_domain wikiPageUsesTemplate Template:Infobox_protein_family.
- HAND_domain wikiPageUsesTemplate Template:InterPro_content.
- HAND_domain wikiPageUsesTemplate Template:Orphan.
- HAND_domain wikiPageUsesTemplate Template:Reflist.
- HAND_domain subject Category:Protein_domains.
- HAND_domain hypernym Domain.
- HAND_domain type Biomolecule.
- HAND_domain type Protein.
- HAND_domain type Chemical.
- HAND_domain type Domain.
- HAND_domain type Thing.
- HAND_domain type Q206229.
- HAND_domain type Q8054.
- HAND_domain comment "In molecular biology, the HAND domain is a protein domain which adopts a secondary structure consisting of four alpha helices, three of which (H2, H3, H4) form an L-like configuration. Helix H2 runs antiparallel to helices H3 and H4, packing closely against helix H4, whilst helix H1 reposes in the concave surface formed by these three helices and runs perpendicular to them. This domain confers DNA and nucleosome binding properties to the proteins in which it occurs.".
- HAND_domain label "HAND domain".
- HAND_domain sameAs m.0h940zh.
- HAND_domain sameAs Q5628942.
- HAND_domain sameAs Q5628942.
- HAND_domain wasDerivedFrom HAND_domain?oldid=591575425.
- HAND_domain depiction PDB_1ofc_EBI.jpg.
- HAND_domain isPrimaryTopicOf HAND_domain.