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- HA-966 abstract "HA-966 or (±) 3-Amino-1-hydroxy-pyrrolidin-2-one is a molecule used in scientific research as a glycine receptor and NMDA receptor antagonist / low efficacy partial agonist. It has neuroprotective and anticonvulsant, anxiolytic, antinociceptive and sedative / hypnotic effects in animal models. Pilot human clinical trials in the early 1960s showed that HA-966 appeared to benefit patients with tremors of extrapyramidal origin.The two enantiomers of HA-966 have differing pharmacological activity. The glycine/N-methyl-D-aspartate receptor antagonist activity is specific to the R-(+) enantiomer, whereas the sedative and ataxic effects are specific to the S-(-) enantiomer.R-(+)-HA-966 did not induce drug-appropriate responding in animals trained to discriminate phencyclidine (PCP) from saline, suggesting that the glycine receptor ligand R-(+)-HA-966 has a significantly different behavioral profile than drugs affecting the ion channel of the NMDA receptor complex.S-(−)-HA-966 has been described as a "γ-hydroxybutyric acid (GHB)-like agent" and a "potent y-butyrolactone-like sedative", but it shows no affinity for the GABAB receptor (GABABR).".
- HA-966 casNumber "1003-51-6".
- HA-966 iupacName "3-Amino-1-hydroxy-pyrrolidin-2-one".
- HA-966 pubchem "1232".
- HA-966 thumbnail Molecular_Structure_of_HA-966.png?width=300.
- HA-966 wikiPageID "36399227".
- HA-966 wikiPageLength "6024".
- HA-966 wikiPageOutDegree "22".
- HA-966 wikiPageRevisionID "678841208".
- HA-966 wikiPageWikiLink Antagonist.
- HA-966 wikiPageWikiLink Anticonvulsant.
- HA-966 wikiPageWikiLink Antinociceptive.
- HA-966 wikiPageWikiLink Anxiolytic.
- HA-966 wikiPageWikiLink Ataxia.
- HA-966 wikiPageWikiLink Ataxic.
- HA-966 wikiPageWikiLink Category:Amines.
- HA-966 wikiPageWikiLink Category:Ketones.
- HA-966 wikiPageWikiLink Category:NMDA_receptor_antagonists.
- HA-966 wikiPageWikiLink Category:Pyrrolidines.
- HA-966 wikiPageWikiLink GABAB_receptor.
- HA-966 wikiPageWikiLink Gamma-Butyrolactone.
- HA-966 wikiPageWikiLink Gamma-Hydroxybutyric_acid.
- HA-966 wikiPageWikiLink Glycine_receptor.
- HA-966 wikiPageWikiLink Hypnotic.
- HA-966 wikiPageWikiLink Intrinsic_activity.
- HA-966 wikiPageWikiLink NMDA_receptor.
- HA-966 wikiPageWikiLink NRX-1074.
- HA-966 wikiPageWikiLink Neuroprotection.
- HA-966 wikiPageWikiLink Neuroprotective.
- HA-966 wikiPageWikiLink Nociception.
- HA-966 wikiPageWikiLink Partial_agonist.
- HA-966 wikiPageWikiLink Phencyclidine.
- HA-966 wikiPageWikiLink Rapastinel.
- HA-966 wikiPageWikiLink Sedative.
- HA-966 wikiPageWikiLinkText "HA-966".
- HA-966 c "4".
- HA-966 casNumber "1003".
- HA-966 chemspiderid "1195".
- HA-966 h "8".
- HA-966 hasPhotoCollection HA-966.
- HA-966 inchi "1".
- HA-966 inchikey "HCKUBNLZMKAEIN-UHFFFAOYAL".
- HA-966 iupacName "3".
- HA-966 molecularWeight "116.11972".
- HA-966 n "2".
- HA-966 o "2".
- HA-966 pubchem "1232".
- HA-966 smiles "O=C1CN".
- HA-966 stdinchi "1".
- HA-966 stdinchikey "HCKUBNLZMKAEIN-UHFFFAOYSA-N".
- HA-966 width "200".
- HA-966 wikiPageUsesTemplate Template:Drugbox.
- HA-966 wikiPageUsesTemplate Template:Glutamatergics.
- HA-966 wikiPageUsesTemplate Template:Reflist.
- HA-966 subject Category:Amines.
- HA-966 subject Category:Ketones.
- HA-966 subject Category:NMDA_receptor_antagonists.
- HA-966 subject Category:Pyrrolidines.
- HA-966 hypernym Molecule.
- HA-966 type Article.
- HA-966 type ChemicalCompound.
- HA-966 type ChemicalSubstance.
- HA-966 type Drug.
- HA-966 type Article.
- HA-966 type Heterocycle.
- HA-966 type ChemicalObject.
- HA-966 type Thing.
- HA-966 type Q8386.
- HA-966 comment "HA-966 or (±) 3-Amino-1-hydroxy-pyrrolidin-2-one is a molecule used in scientific research as a glycine receptor and NMDA receptor antagonist / low efficacy partial agonist. It has neuroprotective and anticonvulsant, anxiolytic, antinociceptive and sedative / hypnotic effects in animal models. Pilot human clinical trials in the early 1960s showed that HA-966 appeared to benefit patients with tremors of extrapyramidal origin.The two enantiomers of HA-966 have differing pharmacological activity.".
- HA-966 label "HA-966".
- HA-966 sameAs m.0k8sxlq.
- HA-966 sameAs HA-966.
- HA-966 sameAs HA-966.
- HA-966 sameAs Q5628879.
- HA-966 sameAs Q5628879.
- HA-966 wasDerivedFrom HA-966?oldid=678841208.
- HA-966 depiction Molecular_Structure_of_HA-966.png.
- HA-966 isPrimaryTopicOf HA-966.