DBpedia 2015-10

Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/H2AFZ> ?p ?o }

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H2AFZ abstract "Histone H2A.Z is a protein that in humans is encoded by the H2AFZ gene. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality. Histone H2AZ is a variant of histone H2A, and is used to mediate the thermosensory response, and is essential to perceive the ambient temperature. Nucleosome occupancy of H2A.Z decreases with temperature, and in vitro assays show that H2A.Z-containing nucleosomes wrap DNA more tightly than canonical H2A nucleosomes in Arabidopsis.(Cell 140: 136–147, 2010) However, in some of the other studies (Nat. Genet. 41, 941–945 and Genes Dev., 21, 1519–1529) have shown that incorporation of H2A.Z in nucleosomes, when it co-occurs with H3.3, makes them weaker. Positioning of H2A.Z containing nucleosomes around transcription start sites has now been shown to affect the downstream gene expression.".
H2AFZ entrezgene "3015".
H2AFZ wikiPageID "14757644".
H2AFZ wikiPageLength "9405".
H2AFZ wikiPageOutDegree "6".
H2AFZ wikiPageRevisionID "678841161".
H2AFZ wikiPageWikiLink Eukaryote.
H2AFZ wikiPageWikiLink Gene.
H2AFZ wikiPageWikiLink Histone.
H2AFZ wikiPageWikiLink INCENP.
H2AFZ wikiPageWikiLink Protein.
H2AFZ wikiPageWikiLink Protein-protein_interaction.
H2AFZ wikiPageWikiLink Protein–protein_interaction.
H2AFZ wikiPageWikiLinkText "H2A.Z".
H2AFZ wikiPageWikiLinkText "H2AFZ".
H2AFZ hasPhotoCollection H2AFZ.
H2AFZ requireManualInspection "no".
H2AFZ summaryText "Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones . The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality. Histone H2AZ is a variant of histone H2A, and is used to mediate the thermosensory response, and is essential to perceive the ambient temperature. Nucleosome occupancy of H2A.Z decreases with temperature, and in vitro assays show that H2A.Z-containing nucleosomes wrap DNA more tightly than canonical H2A nucleosomes in Arabidopsis. However, in some of the other studies have shown that incorporation of H2A.Z in nucleosomes, when it co-occurs with H3.3, makes them weaker. Positioning of H2A.Z containing nucleosomes around transcription start sites has now been shown to affect the downstream gene expression.".
H2AFZ updateCitations "yes".
H2AFZ updatePage "yes".
H2AFZ updateProteinBox "yes".
H2AFZ updateSummary "yes".
H2AFZ wikiPageUsesTemplate Template:Gene-4-stub.
H2AFZ wikiPageUsesTemplate Template:PBB.
H2AFZ wikiPageUsesTemplate Template:PBB_Controls.
H2AFZ wikiPageUsesTemplate Template:PBB_Further_reading.
H2AFZ wikiPageUsesTemplate Template:PBB_Summary.
H2AFZ wikiPageUsesTemplate Template:PDB_Gallery.
H2AFZ wikiPageUsesTemplate Template:Refbegin.
H2AFZ wikiPageUsesTemplate Template:Refend.
H2AFZ wikiPageUsesTemplate Template:Reflist.
H2AFZ hypernym Protein.
H2AFZ type Article.
H2AFZ type Biomolecule.
H2AFZ type Protein.
H2AFZ type Article.
H2AFZ type Thing.
H2AFZ type Q206229.
H2AFZ type Q8054.
H2AFZ comment "Histone H2A.Z is a protein that in humans is encoded by the H2AFZ gene. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4).".
H2AFZ label "H2AFZ".
H2AFZ sameAs m.03gwxtk.
H2AFZ sameAs Q5628810.
H2AFZ sameAs Q5628810.
H2AFZ wasDerivedFrom H2AFZ?oldid=678841161.
H2AFZ isPrimaryTopicOf H2AFZ.