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- Glucarpidase abstract "Glucarpidase (Voraxaze) is an FDA-approved intravenous drug for the treatment of elevated levels of methotrexate (defined as 1 micromol/L) during treatment of cancer patients who have impaired kidney function (and thus cannot reduce the drug to safe levels sufficiently after the drug has been given). Glucarpidase is an enzyme that inactivates methotrexate rapidly after injection. Because this agent reduces systemic levels of methotrexate and could therefore interfere with efficacy, it is not recommended for use in patients with normal or only slightly impaired kidney function or in whom serum levels are normal. The main antidote for methotrexate overdoses prior to the approval of this drug were high doses of folinic acid. However, this agent was not always sufficient at preventing kidney failure due to methotrexate. Glucarpidase also degrades folinic acid so the two should not be used together (within two hours of one another).Glucarpidase, a recombinant form of the bacterial enzyme carboxypeptidase G2 converts methotrexate into glutamate and 2,4-diamino-N(10)-methylpteroic acid. These are generally much less toxic and are excreted largely by the liver. One case series in children has found that high-dose methotrexate therapy can be resumed after an instance of methotrexate-induced acute kidney injury successfully treated with glucarpidase.So far adverse effects that have been reported have been mild and include numbness, tingling, flushing, nausea, vomiting, itching, and headache.".
- Glucarpidase atcPrefix "V03AF09".
- Glucarpidase casNumber "0009074-87-7".
- Glucarpidase iupacName "Recombinant glutamate carboxypeptidase (carboxypeptidase G2)".
- Glucarpidase wikiPageExternalLink glucarpidase.html.
- Glucarpidase wikiPageExternalLink ucm288016.htm.
- Glucarpidase wikiPageID "38020703".
- Glucarpidase wikiPageLength "3790".
- Glucarpidase wikiPageOutDegree "12".
- Glucarpidase wikiPageRevisionID "678834445".
- Glucarpidase wikiPageWikiLink Cancer.
- Glucarpidase wikiPageWikiLink Carboxypeptidase_G2.
- Glucarpidase wikiPageWikiLink Category:Chemotherapeutic_adjuvants.
- Glucarpidase wikiPageWikiLink Enzyme.
- Glucarpidase wikiPageWikiLink Folinic_acid.
- Glucarpidase wikiPageWikiLink Food_and_Drug_Administration.
- Glucarpidase wikiPageWikiLink Glutamate.
- Glucarpidase wikiPageWikiLink Glutamate_carboxypeptidase.
- Glucarpidase wikiPageWikiLink Glutamic_acid.
- Glucarpidase wikiPageWikiLink Headache.
- Glucarpidase wikiPageWikiLink Kidney_failure.
- Glucarpidase wikiPageWikiLink Methotrexate.
- Glucarpidase wikiPageWikiLink Recombinant_DNA.
- Glucarpidase wikiPageWikiLink Renal_failure.
- Glucarpidase wikiPageWikiLink Renal_insufficiency.
- Glucarpidase wikiPageWikiLinkText "Glucarpidase".
- Glucarpidase wikiPageWikiLinkText "glucarpidase".
- Glucarpidase atcPrefix "V03AF09".
- Glucarpidase casNumber "9074".
- Glucarpidase chemicalFormula "CHNOS".
- Glucarpidase chemspiderid "NA".
- Glucarpidase drugName "glucarpidase".
- Glucarpidase drugs.com glucarpidase.html.
- Glucarpidase hasPhotoCollection Glucarpidase.
- Glucarpidase iupacName "Recombinant glutamate carboxypeptidase".
- Glucarpidase iupharLigand "7450".
- Glucarpidase legalUs "Rx-only".
- Glucarpidase routesOfAdministration "IV".
- Glucarpidase tradename "Voraxaze".
- Glucarpidase wikiPageUsesTemplate Template:Drugbox.
- Glucarpidase wikiPageUsesTemplate Template:Reflist.
- Glucarpidase subject Category:Chemotherapeutic_adjuvants.
- Glucarpidase hypernym Drug.
- Glucarpidase type Article.
- Glucarpidase type ChemicalSubstance.
- Glucarpidase type Drug.
- Glucarpidase type Article.
- Glucarpidase type Chemical.
- Glucarpidase type Drug.
- Glucarpidase type ChemicalObject.
- Glucarpidase type Thing.
- Glucarpidase type Q8386.
- Glucarpidase comment "Glucarpidase (Voraxaze) is an FDA-approved intravenous drug for the treatment of elevated levels of methotrexate (defined as 1 micromol/L) during treatment of cancer patients who have impaired kidney function (and thus cannot reduce the drug to safe levels sufficiently after the drug has been given). Glucarpidase is an enzyme that inactivates methotrexate rapidly after injection.".
- Glucarpidase label "Glucarpidase".
- Glucarpidase sameAs m.04khv88.
- Glucarpidase sameAs Glukarpidaza.
- Glucarpidase sameAs Glukarpidaza.
- Glucarpidase sameAs Q5572303.
- Glucarpidase sameAs Q5572303.
- Glucarpidase wasDerivedFrom Glucarpidase?oldid=678834445.
- Glucarpidase isPrimaryTopicOf Glucarpidase.
- Glucarpidase name "glucarpidase".