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- Genetics_of_aging abstract "Genetics of aging is generally concerned with life extension associated with genetic alterations, rather than with accelerated aging diseases leading to reduction in lifespan.The first mutation found to increase longevity in an animal was the age-1 gene in Caenorhabditis elegans. Michael Klass discovered that lifespan of C. elegans could be altered by mutations, but Klass believed that the effect was due to reduced food consumption (calorie restriction). Thomas Johnson later showed that life extension of up to 65% was due to the mutation itself rather than due to calorie restriction, and he named the gene age-1 in the expectation that other genes that control aging would be found. The age-1 gene encodes the catalytic subunit of class-I phosphatidylinositol 3-kinase (PI3K).A decade after Johnson's discovery daf-2, one of the two genes that are essential for dauer larva formation, was shown by Cynthia Kenyon to double C. elegans lifespan. Kenyon showed that the daf-2 mutants, which would form dauers above 25 °C (298 K; 77 °F) would bypass the dauer state below 20 °C (293 K; 68 °F) with a doubling of lifespan. Prior to Kenyon's study it was commonly believed that lifespan could only be increased at the cost of a loss of reproductive capacity, but Kenyon's nematodes maintained youthful reproductive capacity as well as extended youth in general. Subsequent genetic modification (PI3K-null mutation) to C. elegans was shown to extend maximum life span tenfold.According to the GenAge database of aging-related genes, there are over 800 genes extending lifespan in model organisms: 454 in the soil roundworm (Caenorhabditis elegans), 236 in the bakers' yeast (Saccharomyces cerevisiae), 79 in the fruit fly (Drosophila melanogaster) and 68 in the mouse (Mus musculus).Genetic modifications in other species have not achieved as great a lifespan extension as have been seen for C. elegans. Drosophila melanogaster lifespan has been doubled. Genetic mutations in mice can increase maximum lifespan to 1.5 times normal, and up to 1.7 times normal when combined with calorie restriction.".
- Genetics_of_aging thumbnail Dnadamage.png?width=300.
- Genetics_of_aging wikiPageExternalLink genomics.senescence.info.
- Genetics_of_aging wikiPageExternalLink netage-project.org.
- Genetics_of_aging wikiPageID "38852341".
- Genetics_of_aging wikiPageLength "5813".
- Genetics_of_aging wikiPageOutDegree "26".
- Genetics_of_aging wikiPageRevisionID "649074956".
- Genetics_of_aging wikiPageWikiLink Caenorhabditis_elegans.
- Genetics_of_aging wikiPageWikiLink Calorie_restriction.
- Genetics_of_aging wikiPageWikiLink Category:Ageing.
- Genetics_of_aging wikiPageWikiLink Category:Aging-related_genes.
- Genetics_of_aging wikiPageWikiLink Category:Molecular_genetics.
- Genetics_of_aging wikiPageWikiLink Category:Senescence.
- Genetics_of_aging wikiPageWikiLink Class_I_PI_3-kinases.
- Genetics_of_aging wikiPageWikiLink Cynthia_Kenyon.
- Genetics_of_aging wikiPageWikiLink Daf-2.
- Genetics_of_aging wikiPageWikiLink Dauer_larva.
- Genetics_of_aging wikiPageWikiLink Drosophila_melanogaster.
- Genetics_of_aging wikiPageWikiLink House_mouse.
- Genetics_of_aging wikiPageWikiLink Life_extension.
- Genetics_of_aging wikiPageWikiLink Longevity.
- Genetics_of_aging wikiPageWikiLink Maximum_life_span.
- Genetics_of_aging wikiPageWikiLink Model_organism.
- Genetics_of_aging wikiPageWikiLink Model_organisms.
- Genetics_of_aging wikiPageWikiLink Mus_musculus.
- Genetics_of_aging wikiPageWikiLink Mutation.
- Genetics_of_aging wikiPageWikiLink Progeroid_syndromes.
- Genetics_of_aging wikiPageWikiLink Saccharomyces_cerevisiae.
- Genetics_of_aging wikiPageWikiLink Strategies_for_Engineered_Negligible_Senescence.
- Genetics_of_aging wikiPageWikiLink File:Dnadamage.png.
- Genetics_of_aging wikiPageWikiLinkText "Genetics of aging".
- Genetics_of_aging hasPhotoCollection Genetics_of_aging.
- Genetics_of_aging wikiPageUsesTemplate Template:Convert.
- Genetics_of_aging wikiPageUsesTemplate Template:Reflist.
- Genetics_of_aging subject Category:Ageing.
- Genetics_of_aging subject Category:Aging-related_genes.
- Genetics_of_aging subject Category:Molecular_genetics.
- Genetics_of_aging subject Category:Senescence.
- Genetics_of_aging hypernym Gene.
- Genetics_of_aging type Protein.
- Genetics_of_aging type Ailment.
- Genetics_of_aging type Disorder.
- Genetics_of_aging type Process.
- Genetics_of_aging comment "Genetics of aging is generally concerned with life extension associated with genetic alterations, rather than with accelerated aging diseases leading to reduction in lifespan.The first mutation found to increase longevity in an animal was the age-1 gene in Caenorhabditis elegans. Michael Klass discovered that lifespan of C. elegans could be altered by mutations, but Klass believed that the effect was due to reduced food consumption (calorie restriction).".
- Genetics_of_aging label "Genetics of aging".
- Genetics_of_aging sameAs Genetika_starenja.
- Genetics_of_aging sameAs m.0ryvyn9.
- Genetics_of_aging sameAs Гены_старения.
- Genetics_of_aging sameAs Q17016224.
- Genetics_of_aging sameAs Q17016224.
- Genetics_of_aging wasDerivedFrom Genetics_of_aging?oldid=649074956.
- Genetics_of_aging depiction Dnadamage.png.
- Genetics_of_aging isPrimaryTopicOf Genetics_of_aging.