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• Gene_therapy abstract "Gene therapy is the therapeutic delivery of nucleic acid polymers into a patient's cells as a drug to treat disease. Gene therapy could be a way to fix a genetic problem at its source. The polymers are either expressed as proteins, interfere with protein expression, or possibly correct genetic mutations.The most common form uses DNA that encodes a functional, therapeutic gene to replace a mutated gene. The polymer molecule is packaged within a "vector", which carries the molecule inside cells.Gene therapy was conceptualized in 1972, by authors who urged caution before commencing human gene therapy studies. By the late 1980s the technology had already been extensively used on animals, and the first genetic modification of a living human occurred on a trial basis in May 1989 , and the first gene therapy experiment approved by the US Food and Drug Administration (FDA) occurred on September 14, 1990, when Ashanti DeSilva was treated for ADA-SCID. By January 2014, some 2,000 clinical trials had been conducted or approved.Early clinical failures led to dismissals of gene therapy. Clinical successes since 2006 regained researchers' attention, although as of 2014, it was still largely an experimental technique. These include treatment of retinal disease Leber's congenital amaurosis, X-linked SCID, ADA-SCID, adrenoleukodystrophy, chronic lymphocytic leukemia (CLL), acute lymphocytic leukemia (ALL), multiple myeloma, haemophilia and Parkinson's disease. Between 2013 and April 2014, US companies invested over $600 million in the field.The first commercial gene therapy, Gendicine, was approved in China in 2003 for the treatment of certain cancers. In 2011 Neovasculgen was registered in Russia as the first-in-class gene-therapy drug for treatment of peripheral artery disease, including critical limb ischemia.In 2012 Glybera, a treatment for a rare inherited disorder, became the first treatment to be approved for clinical use in either Europe or the United States after its endorsement by the European Commission.".
• Gene_therapy thumbnail Gene_therapy.jpg?width=300.
• Gene_therapy wikiPageExternalLink AAPS2008-000838.PDF.
• Gene_therapy wikiPageExternalLink fulltxt.php?ICID=15907.
• Gene_therapy wikiPageExternalLink genetherapy.shtml.
• Gene_therapy wikiPageExternalLink NCT01639690?term=lentiviral+thalassemia&rank=1.
• Gene_therapy wikiPageExternalLink index.html.
• Gene_therapy wikiPageExternalLink www.asgt.org.
• Gene_therapy wikiPageExternalLink index.html.
• Gene_therapy wikiPageExternalLink www.esgct.eu.
• Gene_therapy wikiPageExternalLink www.gene-watch.org.
• Gene_therapy wikiPageExternalLink molekylaer_medicin_och_genterapi.
• Gene_therapy wikiPageExternalLink 728656.
• Gene_therapy wikiPageExternalLink launch-stem-cell-therapy-trial-offers-hope-patients-inherited-blood-disorder.
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• Gene_therapy wikiPageRevisionID "683666212".
• Gene_therapy wikiPageWikiLink 3D_printing.
• Gene_therapy wikiPageWikiLink ABCD1.
• Gene_therapy wikiPageWikiLink Ablation.
• Gene_therapy wikiPageWikiLink Achromatopsia.
• Gene_therapy wikiPageWikiLink Acute_lymphoblastic_leukemia.
• Gene_therapy wikiPageWikiLink Acute_lymphocytic_leukemia.
• Gene_therapy wikiPageWikiLink Adeno-associated_virus.
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• Gene_therapy wikiPageWikiLink Allotransplantation.
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• Gene_therapy wikiPageWikiLink Antisense.
• Gene_therapy wikiPageWikiLink Antisense_therapy.
• Gene_therapy wikiPageWikiLink Arthritis.
• Gene_therapy wikiPageWikiLink Autologous.
• Gene_therapy wikiPageWikiLink Autotransplantation.
• Gene_therapy wikiPageWikiLink B-cell_chronic_lymphocytic_leukemia.
• Gene_therapy wikiPageWikiLink B-cells.
• Gene_therapy wikiPageWikiLink B_cell.
• Gene_therapy wikiPageWikiLink Basic_research.
• Gene_therapy wikiPageWikiLink Beta-thalassemia.
• Gene_therapy wikiPageWikiLink Beta_thalassemia.
• Gene_therapy wikiPageWikiLink Bioethics.
• Gene_therapy wikiPageWikiLink Biologic_medical_product.
• Gene_therapy wikiPageWikiLink Biopharmaceutical.
• Gene_therapy wikiPageWikiLink Biotechnology.
• Gene_therapy wikiPageWikiLink Blood_disease.
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• Gene_therapy wikiPageWikiLink Broadly_neutralizing_antibody.
• Gene_therapy wikiPageWikiLink CCR5.
• Gene_therapy wikiPageWikiLink CD19.
• Gene_therapy wikiPageWikiLink CD4.
• Gene_therapy wikiPageWikiLink CRISPR.
• Gene_therapy wikiPageWikiLink Cardiac_muscle_cell.
• Gene_therapy wikiPageWikiLink Cardiomyocytes.
• Gene_therapy wikiPageWikiLink Cardiovascular_disease.
• Gene_therapy wikiPageWikiLink Category:1990_introductions.
• Gene_therapy wikiPageWikiLink Category:Applied_genetics.
• Gene_therapy wikiPageWikiLink Category:Bioethics.
• Gene_therapy wikiPageWikiLink Category:Biotechnology.
• Gene_therapy wikiPageWikiLink Category:Emerging_technologies.
• Gene_therapy wikiPageWikiLink Category:Gene_delivery.
• Gene_therapy wikiPageWikiLink Category:Life_extension.
• Gene_therapy wikiPageWikiLink Category:Medical_genetics.
• Gene_therapy wikiPageWikiLink Category:Medical_research.
• Gene_therapy wikiPageWikiLink Category:Molecular_biology.
• Gene_therapy wikiPageWikiLink Choroideremia.
• Gene_therapy wikiPageWikiLink Chromosome.
• Gene_therapy wikiPageWikiLink Chronic_granulomatous_disease.
• Gene_therapy wikiPageWikiLink Chronic_lymphocytic_leukemia.
• Gene_therapy wikiPageWikiLink Claudio_Bordignon.
• Gene_therapy wikiPageWikiLink Clinical_trial.
• Gene_therapy wikiPageWikiLink Clinical_trials.
• Gene_therapy wikiPageWikiLink Clotting_factor.
• Gene_therapy wikiPageWikiLink Coagulation.
• Gene_therapy wikiPageWikiLink Cone_(vision).
• Gene_therapy wikiPageWikiLink Cone_cell.
• Gene_therapy wikiPageWikiLink Coronary_artery_disease.
• Gene_therapy wikiPageWikiLink Critical_limb_ischemia.
• Gene_therapy wikiPageWikiLink Cystic_fibrosis.
• Gene_therapy wikiPageWikiLink Cytomegalovirus.
• Gene_therapy wikiPageWikiLink Cytotoxic_T_cell.
• Gene_therapy wikiPageWikiLink DNA.
• Gene_therapy wikiPageWikiLink Declaration_of_Helsinki.
• Gene_therapy wikiPageWikiLink Department_of_Health_and_Human_Services.
• Gene_therapy wikiPageWikiLink Diabetes.
• Gene_therapy wikiPageWikiLink Diabetes_mellitus.

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