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- Gene_Shearer abstract "Gene Martin Shearer (born April 14, 1937) is an American immunologist who works at the National Institutes of Health (NIH). He first achieved fame for his discovery in 1974 that T lymphocytes recognized chemically modified surface antigens only in the context of self major histocompatibility complex (MHC) encoded molecules, identifying the central feature of antigen recognition by T lymphocytes known as MHC restriction. His discovery of MHC restriction using chemically modified surface antigens was simultaneous with the discovery of MHC restricted T lymphocyte recognition of virus infected cells by Rolf Zinkernagel and Peter Doherty, who received the 1996 Nobel Prize in Physiology or Medicine.When the acquired immune deficiency syndrome (AIDS) epidemic was first identified, Shearer realized that the immune deficiencies occurring in AIDS patients closely resembled the immune deficiencies occurring in experimental murine models of graft versus host disease that he had been studying. Consequently, in 1983 Shearer was one of the first immunologists to begin studying the immune dysregulation in AIDS patients and discovered that infection with human immunodeficiency virus (HIV) resulted in CD4+ T cell dysfunction and immune dysregulation long before the onset of overt clinical disease. At the height of the AIDS epidemic when public concern about HIV exposure was at its peak, Shearer's research revealed that T cell immunity to HIV was protective, providing hope to an increasingly concerned public that HIV infection could be contained.".
- Gene_Shearer wikiPageExternalLink gene-m-shearer.
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- Gene_Shearer wikiPageOutDegree "22".
- Gene_Shearer wikiPageRevisionID "683698177".
- Gene_Shearer wikiPageWikiLink Acquired_immune_deficiency_syndrome.
- Gene_Shearer wikiPageWikiLink Category:1937_births.
- Gene_Shearer wikiPageWikiLink Category:American_immunologists.
- Gene_Shearer wikiPageWikiLink Category:Living_people.
- Gene_Shearer wikiPageWikiLink Category:People_from_Wayne_County,_Kentucky.
- Gene_Shearer wikiPageWikiLink Category:University_of_Tennessee_alumni.
- Gene_Shearer wikiPageWikiLink Category:Western_Kentucky_University_alumni.
- Gene_Shearer wikiPageWikiLink HIV.
- Gene_Shearer wikiPageWikiLink AIDS.
- Gene_Shearer wikiPageWikiLink Human_immunodeficiency_virus.
- Gene_Shearer wikiPageWikiLink Immunologist.
- Gene_Shearer wikiPageWikiLink Immunology.
- Gene_Shearer wikiPageWikiLink MHC_restriction.
- Gene_Shearer wikiPageWikiLink Major_histocompatibility_complex.
- Gene_Shearer wikiPageWikiLink Michael_Sela.
- Gene_Shearer wikiPageWikiLink Monticello,_Kentucky.
- Gene_Shearer wikiPageWikiLink National_Cancer_Institute.
- Gene_Shearer wikiPageWikiLink National_Institutes_of_Health.
- Gene_Shearer wikiPageWikiLink Peter_C._Doherty.
- Gene_Shearer wikiPageWikiLink Rehovot.
- Gene_Shearer wikiPageWikiLink Rolf_M._Zinkernagel.
- Gene_Shearer wikiPageWikiLink Rolf_Zinkernagel.
- Gene_Shearer wikiPageWikiLink University_of_Tennessee.
- Gene_Shearer wikiPageWikiLink University_of_Tennessee_Knoxville.
- Gene_Shearer wikiPageWikiLink Weizmann_Institute_of_Science.
- Gene_Shearer wikiPageWikiLink Western_Kentucky_State_College.
- Gene_Shearer wikiPageWikiLink Western_Kentucky_University.
- Gene_Shearer hasPhotoCollection Gene_Shearer.
- Gene_Shearer wikiPageUsesTemplate Template:Infobox_officeholder.
- Gene_Shearer wikiPageUsesTemplate Template:Multiple_issues.
- Gene_Shearer wikiPageUsesTemplate Template:Reflist.
- Gene_Shearer subject Category:1937_births.
- Gene_Shearer subject Category:American_immunologists.
- Gene_Shearer subject Category:Living_people.
- Gene_Shearer subject Category:People_from_Wayne_County,_Kentucky.
- Gene_Shearer subject Category:University_of_Tennessee_alumni.
- Gene_Shearer subject Category:Western_Kentucky_University_alumni.
- Gene_Shearer hypernym Immunologist.
- Gene_Shearer type Agent.
- Gene_Shearer type OfficeHolder.
- Gene_Shearer type Person.
- Gene_Shearer type Person.
- Gene_Shearer type Agent.
- Gene_Shearer type NaturalPerson.
- Gene_Shearer type Thing.
- Gene_Shearer type Q215627.
- Gene_Shearer type Q5.
- Gene_Shearer type Person.
- Gene_Shearer comment "Gene Martin Shearer (born April 14, 1937) is an American immunologist who works at the National Institutes of Health (NIH). He first achieved fame for his discovery in 1974 that T lymphocytes recognized chemically modified surface antigens only in the context of self major histocompatibility complex (MHC) encoded molecules, identifying the central feature of antigen recognition by T lymphocytes known as MHC restriction.".
- Gene_Shearer label "Gene Shearer".
- Gene_Shearer sameAs m.012z2_k5.
- Gene_Shearer sameAs Q20031585.
- Gene_Shearer sameAs Q20031585.
- Gene_Shearer wasDerivedFrom Gene_Shearer?oldid=683698177.
- Gene_Shearer isPrimaryTopicOf Gene_Shearer.
- Gene_Shearer name "Gene Shearer".