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- Gendicine abstract "Gendicine is a recombinant adenovirus engineered to express wildtype-p53 (rAd-p53). This virus is designed to treat patients with tumors which have mutated p53 genes.Gendicine is the first gene therapy product approved for clinical use in humans. Gendicine is manufactured by Shenzhen SiBiono GeneTech. Gendicine was approved in 2003 by the Chinese State Food and Drug Administration to treat head and neck squamous cell carcinoma.Gendicine enters the tumour cells by way of receptor-mediated endocytosis and begins to over-express genes coding for the p53 protein needed to fight the tumour. Ad-p53 seems to act by stimulating the apoptotic pathway in tumour cells, which increases the expression of tumour suppressor genes and immune response factors (such as the ability of natural killer (NK) cells to exert “bystander” effects). It also decreases the expression of multi-drug resistance, vascular endothelial growth factor and matrix metalloproteinase-2 genes and blocking transcriptional survival signals.This is no close correlation between p53 mutation status of the tumour cells and response to Ad-p53 treatment. Ad-p53 appears to act synergistically with conventional treatments such as chemo- and radiotherapy. This synergy still exists in patients who were able to resist chemotherapy and radiotherapy. There are fewer side effects than conventional therapy.Introgen's Advexin, a similar gene therapy that also uses adenovirus to deliver the p53 gene, was turned down by the FDA in 2008.".
- Gendicine wikiPageID "25687055".
- Gendicine wikiPageLength "2738".
- Gendicine wikiPageOutDegree "8".
- Gendicine wikiPageRevisionID "683067399".
- Gendicine wikiPageWikiLink Adenoviridae.
- Gendicine wikiPageWikiLink Adenovirus.
- Gendicine wikiPageWikiLink Category:Adenoviridae.
- Gendicine wikiPageWikiLink Category:Gene_delivery.
- Gendicine wikiPageWikiLink China_Food_and_Drug_Administration.
- Gendicine wikiPageWikiLink Gene_therapy.
- Gendicine wikiPageWikiLink P53.
- Gendicine wikiPageWikiLink SFDA.
- Gendicine wikiPageWikiLink Shenzhen_SiBiono_GeneTech.
- Gendicine wikiPageWikiLink Squamous-cell_carcinoma.
- Gendicine wikiPageWikiLink Squamous_cell_carcinoma.
- Gendicine wikiPageWikiLinkText "Gendicine".
- Gendicine hasPhotoCollection Gendicine.
- Gendicine wikiPageUsesTemplate Template:Genetics-stub.
- Gendicine wikiPageUsesTemplate Template:Reflist.
- Gendicine subject Category:Adenoviridae.
- Gendicine subject Category:Gene_delivery.
- Gendicine type Organism.
- Gendicine type Technique.
- Gendicine type Organism.
- Gendicine comment "Gendicine is a recombinant adenovirus engineered to express wildtype-p53 (rAd-p53). This virus is designed to treat patients with tumors which have mutated p53 genes.Gendicine is the first gene therapy product approved for clinical use in humans. Gendicine is manufactured by Shenzhen SiBiono GeneTech.".
- Gendicine label "Gendicine".
- Gendicine sameAs Gendicine.
- Gendicine sameAs m.0b6n0p7.
- Gendicine sameAs Q1501344.
- Gendicine sameAs Q1501344.
- Gendicine wasDerivedFrom Gendicine?oldid=683067399.
- Gendicine isPrimaryTopicOf Gendicine.