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- Gemtuzumab_ozogamicin abstract "Gemtuzumab ozogamicin (marketed by Wyeth as Mylotarg) is a drug-linked monoclonal antibody (an antibody-drug conjugate) that was used to treat acute myelogenous leukemia from 2000 to 2010. It was withdrawn from market in June 2010 when a clinical trial showed the drug increased patient death and added no benefit over conventional cancer therapies.Gemtuzumab is a monoclonal antibody to CD33 linked to a cytotoxic agent from the class of calicheamicins. CD33 is expressed in most leukemic blast cells but also in normal hematopoietic cells, the intensity diminishing with maturation of stem cells. In the United States, it was approved under an accelerated-approval process by the FDA in 2000 for use in patients over the age of 60 with relapsed acute myelogenous leukemia (AML); or those who are not considered candidates for standard chemotherapy.Within the first year after approval, the FDA required a black box warning be added to Gemtuzumab packaging. The drug was noted to increase the risk of veno-occlusive disease in the absence of bone marrow transplantation. Later the onset of VOD was shown to occur at increased frequency in Gemtuzumab patients even following bone marrow transplantation. The drug was discussed in a 2008 JAMA article, which criticized the inadequacy of postmarketing surveillance of biologic agents.Common side effects of administration included shivering, fever, nausea and vomiting. Serious side effects included severe myelosuppression (suppressed activity of bone marrow, which is involved in formation of various blood cells [found in 98% of patients]), disorder of the respiratory system, tumor lysis syndrome, Type III hypersensitivity, venous occlusion, and death.".
- Gemtuzumab_ozogamicin atcPrefix "L01".
- Gemtuzumab_ozogamicin atcSuffix "XC05".
- Gemtuzumab_ozogamicin casNumber "220578-59-6".
- Gemtuzumab_ozogamicin drugbank "DB00056".
- Gemtuzumab_ozogamicin wikiPageID "2921579".
- Gemtuzumab_ozogamicin wikiPageLength "6090".
- Gemtuzumab_ozogamicin wikiPageOutDegree "27".
- Gemtuzumab_ozogamicin wikiPageRevisionID "657479934".
- Gemtuzumab_ozogamicin wikiPageWikiLink Acute_myelogenous_leukemia.
- Gemtuzumab_ozogamicin wikiPageWikiLink Acute_myeloid_leukemia.
- Gemtuzumab_ozogamicin wikiPageWikiLink Antibody-drug_conjugate.
- Gemtuzumab_ozogamicin wikiPageWikiLink Atomic_mass_unit.
- Gemtuzumab_ozogamicin wikiPageWikiLink Blood_cell.
- Gemtuzumab_ozogamicin wikiPageWikiLink Bone_marrow.
- Gemtuzumab_ozogamicin wikiPageWikiLink Bone_marrow_suppression.
- Gemtuzumab_ozogamicin wikiPageWikiLink Bone_marrow_transplantation.
- Gemtuzumab_ozogamicin wikiPageWikiLink CD33.
- Gemtuzumab_ozogamicin wikiPageWikiLink Calicheamicin.
- Gemtuzumab_ozogamicin wikiPageWikiLink Category:Antibody-drug_conjugate.
- Gemtuzumab_ozogamicin wikiPageWikiLink Category:Monoclonal_antibodies_for_tumors.
- Gemtuzumab_ozogamicin wikiPageWikiLink Category:Orphan_drugs.
- Gemtuzumab_ozogamicin wikiPageWikiLink Category:Withdrawn_drugs.
- Gemtuzumab_ozogamicin wikiPageWikiLink Fever.
- Gemtuzumab_ozogamicin wikiPageWikiLink Hematopoietic_stem_cell_transplantation.
- Gemtuzumab_ozogamicin wikiPageWikiLink Hepatic_veno-occlusive_disease.
- Gemtuzumab_ozogamicin wikiPageWikiLink Immune_complex_hypersensitivity.
- Gemtuzumab_ozogamicin wikiPageWikiLink Inotuzumab_ozogamicin.
- Gemtuzumab_ozogamicin wikiPageWikiLink Intravenous_therapy.
- Gemtuzumab_ozogamicin wikiPageWikiLink KDa.
- Gemtuzumab_ozogamicin wikiPageWikiLink Monoclonal_antibody.
- Gemtuzumab_ozogamicin wikiPageWikiLink Myelosuppression.
- Gemtuzumab_ozogamicin wikiPageWikiLink Nausea.
- Gemtuzumab_ozogamicin wikiPageWikiLink Respiratory_system.
- Gemtuzumab_ozogamicin wikiPageWikiLink Shiver.
- Gemtuzumab_ozogamicin wikiPageWikiLink Shivering.
- Gemtuzumab_ozogamicin wikiPageWikiLink Stem_cell.
- Gemtuzumab_ozogamicin wikiPageWikiLink Stem_cells.
- Gemtuzumab_ozogamicin wikiPageWikiLink Tumor_lysis_syndrome.
- Gemtuzumab_ozogamicin wikiPageWikiLink Type_III_hypersensitivity.
- Gemtuzumab_ozogamicin wikiPageWikiLink Veno-occlusive_disease.
- Gemtuzumab_ozogamicin wikiPageWikiLink Wyeth.
- Gemtuzumab_ozogamicin wikiPageWikiLinkText "Gemtuzumab ozogamicin".
- Gemtuzumab_ozogamicin wikiPageWikiLinkText "gemtuzumab ozogamicin".
- Gemtuzumab_ozogamicin atcPrefix "L01".
- Gemtuzumab_ozogamicin atcSuffix "XC05".
- Gemtuzumab_ozogamicin casNumber "220578".
- Gemtuzumab_ozogamicin chembl "1201506".
- Gemtuzumab_ozogamicin chemspiderid "NA".
- Gemtuzumab_ozogamicin drugbank "DB00056".
- Gemtuzumab_ozogamicin hasPhotoCollection Gemtuzumab_ozogamicin.
- Gemtuzumab_ozogamicin kegg "D03259".
- Gemtuzumab_ozogamicin legalUs "Rx-only".
- Gemtuzumab_ozogamicin mabType "mab".
- Gemtuzumab_ozogamicin medlineplus "a607075".
- Gemtuzumab_ozogamicin molecularWeight "151".
- Gemtuzumab_ozogamicin pregnancyCategory "D".
- Gemtuzumab_ozogamicin routesOfAdministration Intravenous_therapy.
- Gemtuzumab_ozogamicin source "zu/o".
- Gemtuzumab_ozogamicin target CD33.
- Gemtuzumab_ozogamicin tradename "Mylotarg".
- Gemtuzumab_ozogamicin type "mab".
- Gemtuzumab_ozogamicin verifiedfields "changed".
- Gemtuzumab_ozogamicin verifiedrevid "476992617".
- Gemtuzumab_ozogamicin wikiPageUsesTemplate Template:Drugbox.
- Gemtuzumab_ozogamicin wikiPageUsesTemplate Template:Extracellular_chemotherapeutic_agents.
- Gemtuzumab_ozogamicin wikiPageUsesTemplate Template:Monoclonals_for_tumors.
- Gemtuzumab_ozogamicin subject Category:Antibody-drug_conjugate.
- Gemtuzumab_ozogamicin subject Category:Monoclonal_antibodies_for_tumors.
- Gemtuzumab_ozogamicin subject Category:Orphan_drugs.
- Gemtuzumab_ozogamicin subject Category:Withdrawn_drugs.
- Gemtuzumab_ozogamicin hypernym Antibody.
- Gemtuzumab_ozogamicin type Article.
- Gemtuzumab_ozogamicin type ChemicalSubstance.
- Gemtuzumab_ozogamicin type Drug.
- Gemtuzumab_ozogamicin type Antibody.
- Gemtuzumab_ozogamicin type Article.
- Gemtuzumab_ozogamicin type Chemical.
- Gemtuzumab_ozogamicin type Drug.
- Gemtuzumab_ozogamicin type ChemicalObject.
- Gemtuzumab_ozogamicin type Thing.
- Gemtuzumab_ozogamicin type Q8386.
- Gemtuzumab_ozogamicin comment "Gemtuzumab ozogamicin (marketed by Wyeth as Mylotarg) is a drug-linked monoclonal antibody (an antibody-drug conjugate) that was used to treat acute myelogenous leukemia from 2000 to 2010. It was withdrawn from market in June 2010 when a clinical trial showed the drug increased patient death and added no benefit over conventional cancer therapies.Gemtuzumab is a monoclonal antibody to CD33 linked to a cytotoxic agent from the class of calicheamicins.".
- Gemtuzumab_ozogamicin label "Gemtuzumab ozogamicin".
- Gemtuzumab_ozogamicin sameAs جيمتوزوماب_أوزوغاميسين.
- Gemtuzumab_ozogamicin sameAs Gemtuzumab-Ozogamicin.
- Gemtuzumab_ozogamicin sameAs Gemtuzumab_ozogamicin.
- Gemtuzumab_ozogamicin sameAs ゲムツズマブ_オゾガマイシン.
- Gemtuzumab_ozogamicin sameAs Gemtuzumab.
- Gemtuzumab_ozogamicin sameAs Gentuzumab_ozogamicina.
- Gemtuzumab_ozogamicin sameAs m.08cs96.
- Gemtuzumab_ozogamicin sameAs Gemtuzumab_ozogamicin.
- Gemtuzumab_ozogamicin sameAs Gemtuzumab_ozogamicin.
- Gemtuzumab_ozogamicin sameAs Q412685.
- Gemtuzumab_ozogamicin sameAs Q412685.
- Gemtuzumab_ozogamicin wasDerivedFrom Gemtuzumab_ozogamicin?oldid=657479934.
- Gemtuzumab_ozogamicin isPrimaryTopicOf Gemtuzumab_ozogamicin.