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- Gamendazole abstract "Gamendazole is a novel drug candidate for male contraception. It is an indazole carboxylic acid derived from lonidamine (LND). Gamendazole produced 100% antispermatogenic effects at 25 mg/kg i.p. in rats, whereas 200 mg/kg was fatal for 60% of rats tested. Since gamendazole produced 100% efficacy, it was tested orally. At a dose of 6 mg/kg, 100% of rats were infertile 4 weeks after a single administration. Complete infertility was maintained for 2 weeks, followed by complete recovery in 4 of 7 rats. The other 3 never recovered fertility. Upon dosing 6 mg/kg orally for 7 days, it produced similar infertility results, but only 2 of 7 rats recovered fertility. There were no abnormalities in rates of conception or abnormal conception in rats who recovered fertility.Pathology reports were conducted on gamendazole treated rats. At 25 mg/kg i.p., 6 mg/kg oral, and in animals that survived 200 mg/kg i.p., there were no remarkable findings, with no evidence of inflammation, necrosis, tumors, or hemorrhage. There was also a lack of observable behavioral effects at 25 mg/kg i.p., 6 mg/kg oral, and in animals that survived 200 mg/kg i.p. Gamendazole treatment had no effect on testosterone levels, and was reported to affect Sertoli cell function, leading to decreased levels of inhibin B. Low levels of inhibin B were correlated to the infertility of the rat.".
- Gamendazole iupacName "(E)-3-[1-[(2,4-Dichlorophenyl)methyl]-6-(trifluoromethyl)indazol-3-yl]prop-2-enoic acid".
- Gamendazole thumbnail Gamendazole.svg?width=300.
- Gamendazole wikiPageID "32596353".
- Gamendazole wikiPageLength "3698".
- Gamendazole wikiPageOutDegree "19".
- Gamendazole wikiPageRevisionID "670403041".
- Gamendazole wikiPageWikiLink Activin_and_inhibin.
- Gamendazole wikiPageWikiLink Bleeding.
- Gamendazole wikiPageWikiLink Carboxylic_acid.
- Gamendazole wikiPageWikiLink Category:Carboxylic_acids.
- Gamendazole wikiPageWikiLink Category:Contraception_for_males.
- Gamendazole wikiPageWikiLink Category:Experimental_methods_of_birth_control.
- Gamendazole wikiPageWikiLink Category:Indazoles.
- Gamendazole wikiPageWikiLink Fertilisation.
- Gamendazole wikiPageWikiLink Hemorrhage.
- Gamendazole wikiPageWikiLink Indazole.
- Gamendazole wikiPageWikiLink Inflammation.
- Gamendazole wikiPageWikiLink Intraperitoneal_injection.
- Gamendazole wikiPageWikiLink Lonidamine.
- Gamendazole wikiPageWikiLink Male_contraceptive.
- Gamendazole wikiPageWikiLink Male_infertility.
- Gamendazole wikiPageWikiLink Necrosis.
- Gamendazole wikiPageWikiLink Neoplasm.
- Gamendazole wikiPageWikiLink Pathology.
- Gamendazole wikiPageWikiLink Sertoli_cell.
- Gamendazole wikiPageWikiLink Testosterone.
- Gamendazole wikiPageWikiLink Tumor.
- Gamendazole wikiPageWikiLinkText "Gamendazole".
- Gamendazole wikiPageWikiLinkText "gamendazole".
- Gamendazole hasPhotoCollection Gamendazole.
- Gamendazole imagefile "Gamendazole ball-and-stick model.png".
- Gamendazole imagefile "Gamendazole.svg".
- Gamendazole imagesize "200".
- Gamendazole iupacname "-3".
- Gamendazole othernames "trans-3-acrylic acid)".
- Gamendazole verifiedfields "changed".
- Gamendazole verifiedrevid "442713318".
- Gamendazole watchedfields "changed".
- Gamendazole wikiPageUsesTemplate Template:Chembox.
- Gamendazole wikiPageUsesTemplate Template:Reflist.
- Gamendazole subject Category:Carboxylic_acids.
- Gamendazole subject Category:Contraception_for_males.
- Gamendazole subject Category:Experimental_methods_of_birth_control.
- Gamendazole subject Category:Indazoles.
- Gamendazole hypernym Candidate.
- Gamendazole type Article.
- Gamendazole type ChemicalCompound.
- Gamendazole type ChemicalSubstance.
- Gamendazole type Group.
- Gamendazole type Person.
- Gamendazole type Article.
- Gamendazole type Chemical.
- Gamendazole type Group.
- Gamendazole type Heterocycle.
- Gamendazole type Method.
- Gamendazole type ChemicalObject.
- Gamendazole type Thing.
- Gamendazole type Q11173.
- Gamendazole comment "Gamendazole is a novel drug candidate for male contraception. It is an indazole carboxylic acid derived from lonidamine (LND). Gamendazole produced 100% antispermatogenic effects at 25 mg/kg i.p. in rats, whereas 200 mg/kg was fatal for 60% of rats tested. Since gamendazole produced 100% efficacy, it was tested orally. At a dose of 6 mg/kg, 100% of rats were infertile 4 weeks after a single administration.".
- Gamendazole label "Gamendazole".
- Gamendazole sameAs گامندازول.
- Gamendazole sameAs m.0h1hpd5.
- Gamendazole sameAs Gamendazol.
- Gamendazole sameAs Gamendazol.
- Gamendazole sameAs Q5520039.
- Gamendazole sameAs Q5520039.
- Gamendazole wasDerivedFrom Gamendazole?oldid=670403041.
- Gamendazole depiction Gamendazole.svg.
- Gamendazole isPrimaryTopicOf Gamendazole.