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- Gadd7 abstract "gadd7 (growth arrested DNA-damage inducible gene 7) is a non-coding RNA discovered in the ovaries of the chinese hamster (Cricetulus griseus). Homologs have been identified in the closely related Long-tailed Dwarf Hamster (C. longicaudatus). Although the gene for this RNA contains open reading frames, translation studies found no protein product hence gadd7 has been classified as non-coding RNA.gadd7 was previously characterised as a hydrogen peroxide-inducible transcript but has more recently been linked with lipotoxicity - where the accumulation of lipids in non-adipose tissue brings about cell death. gadd7 appears to be a key element in the lipotoxicty pathway, when it is knocked out the resulting mutant is much more resistant to oxidative stress.The proposed mechanism for gadd7's role in lipotoxicity is: The lipid palmitate builds to high concentration within a cell Reactive oxygen species (ROS) are generated This stress induces the expression of gadd7 A feed-forward mechanism occurs ER stress brings about death of the cell↑ 1.0 1.1 1.2 ↑ ↑ 3.0 3.1 ↑".
- Gadd7 thumbnail Gadd7_ss.png?width=300.
- Gadd7 wikiPageExternalLink pmidlookup?view=long&pmid=7923213.
- Gadd7 wikiPageExternalLink journal.pgen.1000459.
- Gadd7 wikiPageExternalLink S0003-9861(96)90340-9.
- Gadd7 wikiPageExternalLink S0014-5793(97)01568-8.
- Gadd7 wikiPageExternalLink pmidlookup?view=long&pmid=16960261.
- Gadd7 wikiPageExternalLink pmidlookup?view=long&pmid=16319173.
- Gadd7 wikiPageID "28128245".
- Gadd7 wikiPageLength "5625".
- Gadd7 wikiPageOutDegree "23".
- Gadd7 wikiPageRevisionID "678818297".
- Gadd7 wikiPageWikiLink Category:Non-coding_RNA.
- Gadd7 wikiPageWikiLink Cell_death.
- Gadd7 wikiPageWikiLink Chinese_hamster.
- Gadd7 wikiPageWikiLink Cricetulus.
- Gadd7 wikiPageWikiLink ER_stress.
- Gadd7 wikiPageWikiLink Expression_(genetics).
- Gadd7 wikiPageWikiLink Feed_forward_(control).
- Gadd7 wikiPageWikiLink Gene.
- Gadd7 wikiPageWikiLink Gene_expression.
- Gadd7 wikiPageWikiLink Gene_knockout.
- Gadd7 wikiPageWikiLink Hydrogen_peroxide.
- Gadd7 wikiPageWikiLink Lipid.
- Gadd7 wikiPageWikiLink Lipids.
- Gadd7 wikiPageWikiLink Lipotoxicity.
- Gadd7 wikiPageWikiLink Long-tailed_Dwarf_Hamster.
- Gadd7 wikiPageWikiLink Long-tailed_dwarf_hamster.
- Gadd7 wikiPageWikiLink Mutant.
- Gadd7 wikiPageWikiLink Non-coding_RNA.
- Gadd7 wikiPageWikiLink Open_reading_frame.
- Gadd7 wikiPageWikiLink Open_reading_frames.
- Gadd7 wikiPageWikiLink Ovary.
- Gadd7 wikiPageWikiLink Oxidative_stress.
- Gadd7 wikiPageWikiLink Palmitate.
- Gadd7 wikiPageWikiLink Palmitic_acid.
- Gadd7 wikiPageWikiLink Protein.
- Gadd7 wikiPageWikiLink Reactive_oxygen_species.
- Gadd7 wikiPageWikiLink Translation_(biology).
- Gadd7 wikiPageWikiLink Translation_(genetics).
- Gadd7 wikiPageWikiLink Unfolded_protein_response.
- Gadd7 caption "Conserved secondary structure of gadd7 RNA".
- Gadd7 hasPhotoCollection Gadd7.
- Gadd7 id "RF01800".
- Gadd7 name "gadd7".
- Gadd7 name "growth arrested DNA-damage inducible gene 7".
- Gadd7 rfam "RF01800".
- Gadd7 rnaType Gene.
- Gadd7 symbol "gadd7".
- Gadd7 taxDomain "Cricetulus".
- Gadd7 width "300".
- Gadd7 wikiPageUsesTemplate Template:Cite_journal.
- Gadd7 wikiPageUsesTemplate Template:Infobox_rfam.
- Gadd7 wikiPageUsesTemplate Template:Refbegin.
- Gadd7 wikiPageUsesTemplate Template:Refend.
- Gadd7 wikiPageUsesTemplate Template:Reflist.
- Gadd7 wikiPageUsesTemplate Template:Rfam.
- Gadd7 subject Category:Non-coding_RNA.
- Gadd7 hypernym RNA.
- Gadd7 type Article.
- Gadd7 type Protein.
- Gadd7 type Article.
- Gadd7 comment "gadd7 (growth arrested DNA-damage inducible gene 7) is a non-coding RNA discovered in the ovaries of the chinese hamster (Cricetulus griseus). Homologs have been identified in the closely related Long-tailed Dwarf Hamster (C. longicaudatus).".
- Gadd7 label "Gadd7".
- Gadd7 sameAs m.0cm80dp.
- Gadd7 sameAs Q5516305.
- Gadd7 sameAs Q5516305.
- Gadd7 wasDerivedFrom Gadd7?oldid=678818297.
- Gadd7 depiction Gadd7_ss.png.
- Gadd7 isPrimaryTopicOf Gadd7.