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- GYF_domain abstract "In molecular biology, the GYF domain (glycine-tyrosine-phenylalanine domain) is an approximately 60-amino acid protein domain which contains a conserved GP[YF]xxxx[MV]xxWxxx[GN]YF motif. It was identified in the human intracellular protein termed CD2 binding protein 2 (CD2BP2), which binds to a site containing two tandem PPPGHR segments within the cytoplasmic region of CD2. Binding experiments and mutational analyses have demonstrated the critical importance of the GYF tripeptide in ligand binding. A GYF domain is also found in several other eukaryotic proteins of unknown function. It has been proposed that the GYF domain found in these proteins could also be involved in proline-rich sequence recognition. Resolution of the structure of the CD2BP2 GYF domain by NMR spectroscopy revealed a compact domain with a beta-beta-alpha-beta-beta topology, where the single alpha-helix is tilted away from the twisted, anti-parallel beta-sheet. The conserved residues of the GYF domain create a contiguous patch of predominantly hydrophobic nature which forms an integral part of the ligand-binding site. There is limited homology within the C-terminal 20-30 amino acids of various GYF domains, supporting the idea that this part of the domain is structurally but not functionally important.".
- GYF_domain symbol "GYF".
- GYF_domain thumbnail PDB_1syx_EBI.jpg?width=300.
- GYF_domain wikiPageID "33375365".
- GYF_domain wikiPageLength "3103".
- GYF_domain wikiPageOutDegree "26".
- GYF_domain wikiPageRevisionID "646843833".
- GYF_domain wikiPageWikiLink Alpha-helix.
- GYF_domain wikiPageWikiLink Alpha_helix.
- GYF_domain wikiPageWikiLink Amino_acid.
- GYF_domain wikiPageWikiLink Beta-sheet.
- GYF_domain wikiPageWikiLink Beta_sheet.
- GYF_domain wikiPageWikiLink C-terminal.
- GYF_domain wikiPageWikiLink C-terminus.
- GYF_domain wikiPageWikiLink CD2.
- GYF_domain wikiPageWikiLink CD2BP2.
- GYF_domain wikiPageWikiLink Category:Protein_domains.
- GYF_domain wikiPageWikiLink Conserved_sequence.
- GYF_domain wikiPageWikiLink Contiguity.
- GYF_domain wikiPageWikiLink Contiguous.
- GYF_domain wikiPageWikiLink Cytoplasm.
- GYF_domain wikiPageWikiLink Eukaryote.
- GYF_domain wikiPageWikiLink Eukaryotic.
- GYF_domain wikiPageWikiLink Glycine.
- GYF_domain wikiPageWikiLink Homo_sapiens.
- GYF_domain wikiPageWikiLink Hydrophobe.
- GYF_domain wikiPageWikiLink Hydrophobic.
- GYF_domain wikiPageWikiLink Intracellular.
- GYF_domain wikiPageWikiLink Ligand_(biochemistry).
- GYF_domain wikiPageWikiLink Ligand_binding.
- GYF_domain wikiPageWikiLink NMR_spectroscopy.
- GYF_domain wikiPageWikiLink Nuclear_magnetic_resonance_spectroscopy.
- GYF_domain wikiPageWikiLink Phenylalanine.
- GYF_domain wikiPageWikiLink Proline.
- GYF_domain wikiPageWikiLink Protein.
- GYF_domain wikiPageWikiLink Protein_domain.
- GYF_domain wikiPageWikiLink Protein_motif.
- GYF_domain wikiPageWikiLink Structural_motif.
- GYF_domain wikiPageWikiLink Structurally.
- GYF_domain wikiPageWikiLink Structure.
- GYF_domain wikiPageWikiLink Tripeptide.
- GYF_domain wikiPageWikiLink Tyrosine.
- GYF_domain caption "the crystal structure of a binary u5 snrnp complex".
- GYF_domain cdd "cd00072".
- GYF_domain hasPhotoCollection GYF_domain.
- GYF_domain interpro "IPR003169".
- GYF_domain name "GYF".
- GYF_domain pfam "PF02213".
- GYF_domain scop "1".
- GYF_domain smart "GYF".
- GYF_domain symbol "GYF".
- GYF_domain wikiPageUsesTemplate Template:ELM.
- GYF_domain wikiPageUsesTemplate Template:Infobox_protein_family.
- GYF_domain wikiPageUsesTemplate Template:InterPro_content.
- GYF_domain wikiPageUsesTemplate Template:Orphan.
- GYF_domain wikiPageUsesTemplate Template:Reflist.
- GYF_domain subject Category:Protein_domains.
- GYF_domain type Biomolecule.
- GYF_domain type Protein.
- GYF_domain type Chemical.
- GYF_domain type Domain.
- GYF_domain type Thing.
- GYF_domain type Q206229.
- GYF_domain type Q8054.
- GYF_domain comment "In molecular biology, the GYF domain (glycine-tyrosine-phenylalanine domain) is an approximately 60-amino acid protein domain which contains a conserved GP[YF]xxxx[MV]xxWxxx[GN]YF motif. It was identified in the human intracellular protein termed CD2 binding protein 2 (CD2BP2), which binds to a site containing two tandem PPPGHR segments within the cytoplasmic region of CD2.".
- GYF_domain label "GYF domain".
- GYF_domain sameAs m.0h97r5n.
- GYF_domain sameAs Q5515082.
- GYF_domain sameAs Q5515082.
- GYF_domain wasDerivedFrom GYF_domain?oldid=646843833.
- GYF_domain depiction PDB_1syx_EBI.jpg.
- GYF_domain isPrimaryTopicOf GYF_domain.