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- GTPgammaS abstract "GTPgammaS (GTPγS, guanosine 5'-O-[gamma-thio]triphosphate) is a non-hydrolyzable or slowly hydrolyzable G-protein-activating analog of guanosine triphosphate (GTP). Many GTP binding proteins demonstrate activity when bound to GTP, and are inactivated via the hydrolysis of the phosphodiester bond that links the γ-phosphate to the remainder of the nucleotide, leaving a bound guanosine diphosphate (GDP) and releasing an inorganic phosphate. This usually occurs rapidly, and the GTP binding protein can then only be activated by exchanging the GDP for a new GTP molecule. The substitution of sulfur for one of the oxygens of the γ-phosphate of GTP creates a nucleotide that either cannot be hydrolyzed or is only slowly hydrolyzed. This prevents the GTP binding proteins from being inactivated, and allows the cellular processes that they carry out when active to be more easily studied. The consequences of the constitutive activation of GTP binding proteins include stimulation of phosphoinositide hydrolysis, cyclic AMP accumulation or elimination, and activation of specific proto-oncogenes. The 35S labelled radioligand of the compound, 35SGTPγS, is used in autoradiography and G-protein binding studies.".
- GTPgammaS iupacName "[(2S,3R,4S,5S)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydroxyphosphinothioyl hydrogen phosphate".
- GTPgammaS thumbnail GTP-gamma-S.svg?width=300.
- GTPgammaS wikiPageID "13788752".
- GTPgammaS wikiPageLength "2366".
- GTPgammaS wikiPageOutDegree "12".
- GTPgammaS wikiPageRevisionID "668565909".
- GTPgammaS wikiPageWikiLink Autoradiograph.
- GTPgammaS wikiPageWikiLink Autoradiography.
- GTPgammaS wikiPageWikiLink Category:Nucleotides.
- GTPgammaS wikiPageWikiLink Cyclic_AMP.
- GTPgammaS wikiPageWikiLink Cyclic_adenosine_monophosphate.
- GTPgammaS wikiPageWikiLink G-protein.
- GTPgammaS wikiPageWikiLink G_protein.
- GTPgammaS wikiPageWikiLink Guanosine_diphosphate.
- GTPgammaS wikiPageWikiLink Guanosine_triphosphate.
- GTPgammaS wikiPageWikiLink Hydrolysis.
- GTPgammaS wikiPageWikiLink Oncogene.
- GTPgammaS wikiPageWikiLink Phosphate.
- GTPgammaS wikiPageWikiLink Phosphatidylinositol.
- GTPgammaS wikiPageWikiLink Phosphodiester_bond.
- GTPgammaS wikiPageWikiLink Phosphoinositide.
- GTPgammaS wikiPageWikiLink Sulfur.
- GTPgammaS wikiPageWikiLinkText "GTP-gamma-S".
- GTPgammaS wikiPageWikiLinkText "GTPgammaS".
- GTPgammaS hasPhotoCollection GTPgammaS.
- GTPgammaS imagefile "GTP-gamma-S.svg".
- GTPgammaS imagesize "300".
- GTPgammaS iupacname "[-5--3,4-dihydroxyoxolan-2-yl]methyl dihydroxyphosphinothioyl hydrogen phosphate".
- GTPgammaS verifiedrevid "425009413".
- GTPgammaS watchedfields "changed".
- GTPgammaS wikiPageUsesTemplate Template:Biochem-stub.
- GTPgammaS wikiPageUsesTemplate Template:Chembox.
- GTPgammaS wikiPageUsesTemplate Template:Nucleobases,_nucleosides,_and_nucleotides.
- GTPgammaS subject Category:Nucleotides.
- GTPgammaS type Article.
- GTPgammaS type ChemicalCompound.
- GTPgammaS type ChemicalSubstance.
- GTPgammaS type Article.
- GTPgammaS type Chemical.
- GTPgammaS type Nucleoside.
- GTPgammaS type Organophosphate.
- GTPgammaS type Organophosphate.
- GTPgammaS type ChemicalObject.
- GTPgammaS type Thing.
- GTPgammaS type Q11173.
- GTPgammaS comment "GTPgammaS (GTPγS, guanosine 5'-O-[gamma-thio]triphosphate) is a non-hydrolyzable or slowly hydrolyzable G-protein-activating analog of guanosine triphosphate (GTP). Many GTP binding proteins demonstrate activity when bound to GTP, and are inactivated via the hydrolysis of the phosphodiester bond that links the γ-phosphate to the remainder of the nucleotide, leaving a bound guanosine diphosphate (GDP) and releasing an inorganic phosphate.".
- GTPgammaS label "GTPgammaS".
- GTPgammaS sameAs GTPγS.
- GTPgammaS sameAs Guanosine_5-(xcexb3-thio)triphosphate.
- GTPgammaS sameAs m.03cj9qn.
- GTPgammaS sameAs GTPgamaS.
- GTPgammaS sameAs GTPgamaS.
- GTPgammaS sameAs Q5514740.
- GTPgammaS sameAs Q5514740.
- GTPgammaS wasDerivedFrom GTPgammaS?oldid=668565909.
- GTPgammaS depiction GTP-gamma-S.svg.
- GTPgammaS isPrimaryTopicOf GTPgammaS.