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- GSK2606414 abstract "GSK2606414 is a drug which is the first selective inhibitor discovered for the enzyme protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK), which is involved in various processes relating to cancer and neurodegenerative disorders. GSK2606414 was found to be a potent and selective inhibitor of PERK, with good oral bioavailability and blood-brain barrier penetration. PERK mediates the unfolded protein response pathway which is involved in the initiation of protein synthesis, and this pathway has been implicated in the neurotoxicity of various diseases including prion and Alzheimer's diseases. Treatment with GSK2606414 was found to be neuroprotective in mice against damage caused by prions, and prevented the development of cognitive deficits and other clinical manifestations of prion disease. Extension of lifespan in treated mice was, however, not recorded. However, side effects such as weight loss and elevated blood glucose levels were also observed, likely due to unwanted inhibition of PERK in the pancreas gland, where it is involved in regulating insulin production.".
- GSK2606414 casNumber "1337531-36-8".
- GSK2606414 iupacName "1-[5-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)indolin-1-yl]-2-(3-trifluoromethylphenyl)ethanone".
- GSK2606414 pubchem "53469448".
- GSK2606414 thumbnail GSK2606414_structure.png?width=300.
- GSK2606414 wikiPageID "40761197".
- GSK2606414 wikiPageLength "4210".
- GSK2606414 wikiPageOutDegree "4".
- GSK2606414 wikiPageRevisionID "678499596".
- GSK2606414 wikiPageWikiLink Category:Drugs_acting_on_the_nervous_system.
- GSK2606414 wikiPageWikiLink EIF2AK3.
- GSK2606414 wikiPageWikiLink Enzyme.
- GSK2606414 wikiPageWikiLink Unfolded_protein_response.
- GSK2606414 wikiPageWikiLinkText "GSK2606414".
- GSK2606414 c "24".
- GSK2606414 casNumber "1337531".
- GSK2606414 chemspiderid "28643060".
- GSK2606414 f "3".
- GSK2606414 h "20".
- GSK2606414 hasPhotoCollection GSK2606414.
- GSK2606414 inchi "1".
- GSK2606414 inchikey "SIXVRXARNAVBTC-UHFFFAOYAA".
- GSK2606414 iupacName "1".
- GSK2606414 molecularWeight "451.44".
- GSK2606414 n "5".
- GSK2606414 o "1".
- GSK2606414 pdbLigand "0".
- GSK2606414 pubchem "53469448".
- GSK2606414 smiles "CN1C2=NC=NC=C2C=C1".
- GSK2606414 stdinchi "1".
- GSK2606414 stdinchikey "SIXVRXARNAVBTC-UHFFFAOYSA-N".
- GSK2606414 width "240".
- GSK2606414 wikiPageUsesTemplate Template:Drugbox.
- GSK2606414 wikiPageUsesTemplate Template:Nervous-system-drug-stub.
- GSK2606414 wikiPageUsesTemplate Template:Reflist.
- GSK2606414 subject Category:Drugs_acting_on_the_nervous_system.
- GSK2606414 hypernym Drug.
- GSK2606414 type ChemicalSubstance.
- GSK2606414 type Drug.
- GSK2606414 type ChemicalObject.
- GSK2606414 type Thing.
- GSK2606414 type Q8386.
- GSK2606414 comment "GSK2606414 is a drug which is the first selective inhibitor discovered for the enzyme protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK), which is involved in various processes relating to cancer and neurodegenerative disorders. GSK2606414 was found to be a potent and selective inhibitor of PERK, with good oral bioavailability and blood-brain barrier penetration.".
- GSK2606414 label "GSK2606414".
- GSK2606414 sameAs m.0y638qn.
- GSK2606414 sameAs GSK2606414.
- GSK2606414 sameAs GSK2606414.
- GSK2606414 sameAs Q15409439.
- GSK2606414 sameAs Q15409439.
- GSK2606414 wasDerivedFrom GSK2606414?oldid=678499596.
- GSK2606414 depiction GSK2606414_structure.png.
- GSK2606414 isPrimaryTopicOf GSK2606414.