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- Frank_Grosveld abstract "Franklin Gerardus "Frank" Grosveld FRS (born 18 August 1948) is a Dutch molecular biologist whose research interests are in the regulation of transcription during development with a particular emphasis on mammalian erythroid differentiation. He obtained his PhD at McGill University, Montreal and after completing two postdoctoral periods with Charles Weissmann (Zurich) and Richard Flavell (Amsterdam and London) he started his own research group at the National Institute for Medical Research, Mill Hill. He is a professor and Head of the Department of Cell Biology at the Erasmus MC, Rotterdam. He is a fellow of the Royal Society and a member of the Royal Netherlands Academy of Arts and Sciences since 1994.Grosveld has been conducting research on the regulation of gene expression over thirty years. In his post-doctoral research he constructed the first reliable method for cloning human DNA cosmids - at the time an extremely difficult but rewarding accomplishment that has since been adopted by many other laboratories. By using the globin gene cluster he made the ground-breaking discovery of a locus control region located upstream of the gene itself and governing overall control of globin gene expression. After this first report, locus control regions have now been identified for many genes and have permitted for example the ectopic expression of genes in transgenic mice. In further studies he identified chromatin loops and the hubs that hold the loops together. His more recent excursions into erythroid differentiation have made the key identification of the transcription factor GATA1, a major and unique advance into understanding erythroid cell development. Along with major research advances he has also developed new technologies, such as 4C technology (a modification of the 3C technology invented previously by others) that makes possible examination of chromatin conformation on a chip and constructed a number of spin off companies. He has mentored a large number of PhDs and postdocs, many of whom have gone on to academic positions all over the world and are now eminent scientists leading groups of their own.Grosveld's research on the control of globin gene expression has been selected as one of the top ten achievements of Medical Research Council (UK) (MRC) in the 20th century by Higher Education and Research Opportunities in the UK. He was awarded the Louis-Jeantet Prize for Medicine (1991) and the Spinozapremie (Spinoza Prize) (1995). He was selected as academy professor of Royal Netherlands Academy of Arts and Sciences in 2008.".
- Frank_Grosveld birthDate "1948-08-18".
- Frank_Grosveld birthYear "1948".
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- Frank_Grosveld wikiPageWikiLink Category:Molecular_biologists.
- Frank_Grosveld wikiPageWikiLink Charles_Weissmann.
- Frank_Grosveld wikiPageWikiLink Chromatin.
- Frank_Grosveld wikiPageWikiLink Cloning.
- Frank_Grosveld wikiPageWikiLink Cosmid.
- Frank_Grosveld wikiPageWikiLink Ectopic_expression.
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- Frank_Grosveld wikiPageWikiLink Erythroid.
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- Frank_Grosveld wikiPageWikiLink GATA1.
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- Frank_Grosveld wikiPageWikiLink Globin.
- Frank_Grosveld wikiPageWikiLink Higher_Education_and_Research_Opportunities_in_the_UK.
- Frank_Grosveld wikiPageWikiLink Locus_control_region.
- Frank_Grosveld wikiPageWikiLink Louis-Jeantet_Prize_for_Medicine.
- Frank_Grosveld wikiPageWikiLink McGill_University.
- Frank_Grosveld wikiPageWikiLink Medical_Research_Council_(UK).
- Frank_Grosveld wikiPageWikiLink Medical_Research_Council_(United_Kingdom).
- Frank_Grosveld wikiPageWikiLink National_Institute_for_Medical_Research.
- Frank_Grosveld wikiPageWikiLink Red_blood_cell.
- Frank_Grosveld wikiPageWikiLink Richard_A._Flavell.
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- Frank_Grosveld wikiPageWikiLink Spinoza_Prize.
- Frank_Grosveld wikiPageWikiLink Spinozapremie.
- Frank_Grosveld wikiPageWikiLink Transcription_factor.
- Frank_Grosveld wikiPageWikiLink Transgenic_mice.
- Frank_Grosveld wikiPageWikiLinkText "Frank Grosveld".
- Frank_Grosveld wikiPageWikiLinkText "Franklin Gerardus Grosveld".
- Frank_Grosveld dateOfBirth "1948-08-18".
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- Frank_Grosveld name "Grosveld, Frank".
- Frank_Grosveld shortDescription "Dutch molecular biologist".
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- Frank_Grosveld description "Dutch molecular biologist".
- Frank_Grosveld description "Dutch molecular biologist".
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- Frank_Grosveld subject Category:Members_of_the_Royal_Netherlands_Academy_of_Arts_and_Sciences.
- Frank_Grosveld subject Category:Molecular_biologists.
- Frank_Grosveld hypernym Biologist.
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- Frank_Grosveld comment "Franklin Gerardus "Frank" Grosveld FRS (born 18 August 1948) is a Dutch molecular biologist whose research interests are in the regulation of transcription during development with a particular emphasis on mammalian erythroid differentiation.".
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- Frank_Grosveld givenName "Frank".
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- Frank_Grosveld name "Frank Grosveld".
- Frank_Grosveld name "Grosveld, Frank".
- Frank_Grosveld surname "Grosveld".