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- Folding_funnel abstract "The folding funnel hypothesis is a specific version of the energy landscape theory of protein folding, which assumes that a protein's native state corresponds to its free energy minimum under the solution conditions usually encountered in cells. Although energy landscapes may be "rough", with many non-native local minima in which partially folded proteins can become trapped, the folding funnel hypothesis assumes that the native state is a deep free energy minimum with steep walls, corresponding to a single well-defined tertiary structure.The folding funnel hypothesis is closely related to the hydrophobic collapse hypothesis, under which the driving force for protein folding is the stabilization associated with the sequestration of hydrophobic amino acid side chains in the interior of the folded protein. This allows the water solvent to maximize its entropy, lowering the total free energy. On the side of the protein, free energy is further lowered by favorable energetic contacts: isolation of electrostatically charged side chains on the solvent-accessible protein surface and neutralization of salt bridges within the protein's core. The molten globule state predicted by the folding funnel theory as an ensemble of folding intermediates thus corresponds to a protein in which hydrophobic collapse has occurred but many native contacts, or close residue-residue interactions represented in the native state, have yet to form.In the canonical depiction of the folding funnel, the depth of the well represents the energetic stabilization of the native state versus the denatured state, and the width of the well represents the conformational entropy of the system. The surface outside the well is shown as relatively flat to represent the heterogeneity of the random coil state. The theory's name derives from an analogy between the shape of the well and a physical funnel, in which dispersed liquid is concentrated into a single narrow area.".
- Folding_funnel thumbnail Folding_funnel_schematic.svg?width=300.
- Folding_funnel wikiPageID "6893544".
- Folding_funnel wikiPageLength "3114".
- Folding_funnel wikiPageOutDegree "25".
- Folding_funnel wikiPageRevisionID "573333486".
- Folding_funnel wikiPageWikiLink Accessible_surface_area.
- Folding_funnel wikiPageWikiLink Amino_acid.
- Folding_funnel wikiPageWikiLink Biomolecular_structure.
- Folding_funnel wikiPageWikiLink Category:Protein_structure.
- Folding_funnel wikiPageWikiLink Cell_(biology).
- Folding_funnel wikiPageWikiLink Chaperone_(protein).
- Folding_funnel wikiPageWikiLink Conformational_entropy.
- Folding_funnel wikiPageWikiLink Denaturation_(biochemistry).
- Folding_funnel wikiPageWikiLink Energy_landscape.
- Folding_funnel wikiPageWikiLink Funnel.
- Folding_funnel wikiPageWikiLink Hydrophobe.
- Folding_funnel wikiPageWikiLink Hydrophobic.
- Folding_funnel wikiPageWikiLink Hydrophobic_collapse.
- Folding_funnel wikiPageWikiLink Levinthal_paradox.
- Folding_funnel wikiPageWikiLink Levinthals_paradox.
- Folding_funnel wikiPageWikiLink Local_minima.
- Folding_funnel wikiPageWikiLink Maxima_and_minima.
- Folding_funnel wikiPageWikiLink Molten_globule.
- Folding_funnel wikiPageWikiLink Native_contact.
- Folding_funnel wikiPageWikiLink Native_state.
- Folding_funnel wikiPageWikiLink Protein.
- Folding_funnel wikiPageWikiLink Protein_folding.
- Folding_funnel wikiPageWikiLink Protein_structure_prediction.
- Folding_funnel wikiPageWikiLink Random_coil.
- Folding_funnel wikiPageWikiLink Salt_bridge_(protein).
- Folding_funnel wikiPageWikiLink Salt_bridge_(protein_and_supramolecular).
- Folding_funnel wikiPageWikiLink Side_chain.
- Folding_funnel wikiPageWikiLink Tertiary_structure.
- Folding_funnel wikiPageWikiLink Thermodynamic_free_energy.
- Folding_funnel wikiPageWikiLink File:Folding_funnel_schematic.svg.
- Folding_funnel wikiPageWikiLinkText "Folding funnel".
- Folding_funnel wikiPageWikiLinkText "folding funnel".
- Folding_funnel wikiPageWikiLinkText "funnel-like energy landscapes".
- Folding_funnel wikiPageWikiLinkText "protein folding funnels".
- Folding_funnel hasPhotoCollection Folding_funnel.
- Folding_funnel wikiPageUsesTemplate Template:Biochem-stub.
- Folding_funnel wikiPageUsesTemplate Template:Cite_book.
- Folding_funnel wikiPageUsesTemplate Template:Cite_journal.
- Folding_funnel subject Category:Protein_structure.
- Folding_funnel hypernym Version.
- Folding_funnel type Work.
- Folding_funnel type Biophysic.
- Folding_funnel comment "The folding funnel hypothesis is a specific version of the energy landscape theory of protein folding, which assumes that a protein's native state corresponds to its free energy minimum under the solution conditions usually encountered in cells.".
- Folding_funnel label "Folding funnel".
- Folding_funnel sameAs Funil_de_pregamento.
- Folding_funnel sameAs Folding_funnel.
- Folding_funnel sameAs m.0gvp1z.
- Folding_funnel sameAs Q5464306.
- Folding_funnel sameAs Q5464306.
- Folding_funnel wasDerivedFrom Folding_funnel?oldid=573333486.
- Folding_funnel depiction Folding_funnel_schematic.svg.
- Folding_funnel isPrimaryTopicOf Folding_funnel.