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- Focal_adhesion_targeting_region abstract "In molecular biology, the focal adhesion targeting region is a conserved domain found on focal adhesion kinases.Focal adhesion kinases (FAK) are tyrosine kinases found in focal adhesions, intracellular signalling complexes that are formed following engagement of the extracellular matrix by integrins. The C-terminal focal adhesion targeting (FAT) region is necessary and sufficient for localizing FAK to focal adhesions. The crystal structure of FAT shows it forms a four-helix bundle that resembles those found in two other proteins involved in cell adhesion, alpha-catenin and vinculin. The binding of FAT to the focal adhesion protein, paxillin, requires the integrity of the helical bundle, whereas binding to another focal adhesion protein, talin, does not.".
- Focal_adhesion_targeting_region symbol "Focal_AT".
- Focal_adhesion_targeting_region thumbnail PDB_1k40_EBI.jpg?width=300.
- Focal_adhesion_targeting_region wikiPageID "32774446".
- Focal_adhesion_targeting_region wikiPageLength "1734".
- Focal_adhesion_targeting_region wikiPageOutDegree "18".
- Focal_adhesion_targeting_region wikiPageRevisionID "647420988".
- Focal_adhesion_targeting_region wikiPageWikiLink Alpha-catenin.
- Focal_adhesion_targeting_region wikiPageWikiLink Alpha_catenin.
- Focal_adhesion_targeting_region wikiPageWikiLink Alpha_helix.
- Focal_adhesion_targeting_region wikiPageWikiLink C-terminal.
- Focal_adhesion_targeting_region wikiPageWikiLink C-terminus.
- Focal_adhesion_targeting_region wikiPageWikiLink Category:Protein_domains.
- Focal_adhesion_targeting_region wikiPageWikiLink Cell_adhesion.
- Focal_adhesion_targeting_region wikiPageWikiLink Cell_signaling.
- Focal_adhesion_targeting_region wikiPageWikiLink Cell_signalling.
- Focal_adhesion_targeting_region wikiPageWikiLink Crystal_structure.
- Focal_adhesion_targeting_region wikiPageWikiLink Extracellular_matrix.
- Focal_adhesion_targeting_region wikiPageWikiLink Focal_adhesion.
- Focal_adhesion_targeting_region wikiPageWikiLink Focal_adhesion_kinase.
- Focal_adhesion_targeting_region wikiPageWikiLink Focal_adhesions.
- Focal_adhesion_targeting_region wikiPageWikiLink Integrin.
- Focal_adhesion_targeting_region wikiPageWikiLink Integrins.
- Focal_adhesion_targeting_region wikiPageWikiLink Intracellular.
- Focal_adhesion_targeting_region wikiPageWikiLink PTK2.
- Focal_adhesion_targeting_region wikiPageWikiLink Paxillin.
- Focal_adhesion_targeting_region wikiPageWikiLink Protein.
- Focal_adhesion_targeting_region wikiPageWikiLink Protein_domain.
- Focal_adhesion_targeting_region wikiPageWikiLink Talin.
- Focal_adhesion_targeting_region wikiPageWikiLink Tyrosine_kinase.
- Focal_adhesion_targeting_region wikiPageWikiLink Tyrosine_kinases.
- Focal_adhesion_targeting_region wikiPageWikiLink Vinculin.
- Focal_adhesion_targeting_region wikiPageWikiLinkText "FAT".
- Focal_adhesion_targeting_region wikiPageWikiLinkText "focal adhesion targeting domain".
- Focal_adhesion_targeting_region wikiPageWikiLinkText "focal adhesion targeting".
- Focal_adhesion_targeting_region caption "crystal structure of the fat domain of focal adhesion kinase".
- Focal_adhesion_targeting_region hasPhotoCollection Focal_adhesion_targeting_region.
- Focal_adhesion_targeting_region interpro "IPR005189".
- Focal_adhesion_targeting_region name "Focal adhesion targeting region".
- Focal_adhesion_targeting_region pfam "PF03623".
- Focal_adhesion_targeting_region scop "1".
- Focal_adhesion_targeting_region symbol "Focal_AT".
- Focal_adhesion_targeting_region wikiPageUsesTemplate Template:ELM.
- Focal_adhesion_targeting_region wikiPageUsesTemplate Template:Infobox_protein_family.
- Focal_adhesion_targeting_region wikiPageUsesTemplate Template:InterPro_content.
- Focal_adhesion_targeting_region wikiPageUsesTemplate Template:Reflist.
- Focal_adhesion_targeting_region subject Category:Protein_domains.
- Focal_adhesion_targeting_region hypernym Domain.
- Focal_adhesion_targeting_region type Biomolecule.
- Focal_adhesion_targeting_region type Protein.
- Focal_adhesion_targeting_region type Chemical.
- Focal_adhesion_targeting_region type Domain.
- Focal_adhesion_targeting_region type Thing.
- Focal_adhesion_targeting_region type Q206229.
- Focal_adhesion_targeting_region type Q8054.
- Focal_adhesion_targeting_region comment "In molecular biology, the focal adhesion targeting region is a conserved domain found on focal adhesion kinases.Focal adhesion kinases (FAK) are tyrosine kinases found in focal adhesions, intracellular signalling complexes that are formed following engagement of the extracellular matrix by integrins. The C-terminal focal adhesion targeting (FAT) region is necessary and sufficient for localizing FAK to focal adhesions.".
- Focal_adhesion_targeting_region label "Focal adhesion targeting region".
- Focal_adhesion_targeting_region sameAs m.0h3rvvz.
- Focal_adhesion_targeting_region sameAs Q5463840.
- Focal_adhesion_targeting_region sameAs Q5463840.
- Focal_adhesion_targeting_region wasDerivedFrom Focal_adhesion_targeting_region?oldid=647420988.
- Focal_adhesion_targeting_region depiction PDB_1k40_EBI.jpg.
- Focal_adhesion_targeting_region isPrimaryTopicOf Focal_adhesion_targeting_region.