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- Flippase abstract "flippases (rarely, flipases) are a family of transmembrane lipid transporter enzymes located in the membrane responsible for aiding the movement of phospholipid molecules between the two leaflets that compose a cell's membrane (transverse diffusion). Their existence was predicted in 1972 by Mark Bretscher, who also named them, to explain how an asymmetric phospholipid bilayer could be formed. Although phospholipids diffuse rapidly in the plane of the membrane, their polar head groups cannot pass easily through the hydrophobic center of the bilayer, limiting their diffusion in this dimension. Some flippases are energy-independent and bidirectional, catalyzing reversible equilibration of phospholipid between the two sides of the membrane, whereas others are energy-dependent and unidirectional, using energy from ATP hydrolysis to pump the phospholipid in a preferred direction.Many cells maintain asymmetric distributions of phospholipids between their cytoplasmic and exoplasmic membrane leaflets. The loss of asymmetry, in particular the appearance of the anionic phospholipid phosphatidylserine on the exoplasmic face, can serve as an early indicator of apoptosis. This effect has been observed in neurons as a response to amyloid beta peptides, thought to be a primary cause of the neurodegenerative effects of Alzheimer's disease.".
- Flippase wikiPageID "7880685".
- Flippase wikiPageLength "2841".
- Flippase wikiPageOutDegree "17".
- Flippase wikiPageRevisionID "681686198".
- Flippase wikiPageWikiLink Adenosine_triphosphate.
- Flippase wikiPageWikiLink Alzheimers_disease.
- Flippase wikiPageWikiLink Amyloid_beta.
- Flippase wikiPageWikiLink Anion.
- Flippase wikiPageWikiLink Apoptosis.
- Flippase wikiPageWikiLink Category:Integral_membrane_proteins.
- Flippase wikiPageWikiLink Cell_membrane.
- Flippase wikiPageWikiLink Chemical_polarity.
- Flippase wikiPageWikiLink Enzyme.
- Flippase wikiPageWikiLink Hydrophobe.
- Flippase wikiPageWikiLink Hydrophobic.
- Flippase wikiPageWikiLink Ion.
- Flippase wikiPageWikiLink Lipid_bilayer.
- Flippase wikiPageWikiLink Mark_Bretscher.
- Flippase wikiPageWikiLink Neurodegeneration.
- Flippase wikiPageWikiLink Neurodegenerative.
- Flippase wikiPageWikiLink Neuron.
- Flippase wikiPageWikiLink Phosphatidylserine.
- Flippase wikiPageWikiLink Phospholipid.
- Flippase wikiPageWikiLink Phospholipid_bilayer.
- Flippase wikiPageWikiLink Phospholipid_scramblase.
- Flippase wikiPageWikiLink Scramblase.
- Flippase wikiPageWikiLinkText "Flippase".
- Flippase wikiPageWikiLinkText "flip-flop".
- Flippase wikiPageWikiLinkText "flippase".
- Flippase wikiPageWikiLinkText "phospholipid asymmetry".
- Flippase hasPhotoCollection Flippase.
- Flippase wikiPageUsesTemplate Template:UMichOPM.
- Flippase subject Category:Integral_membrane_proteins.
- Flippase hypernym Family.
- Flippase comment "flippases (rarely, flipases) are a family of transmembrane lipid transporter enzymes located in the membrane responsible for aiding the movement of phospholipid molecules between the two leaflets that compose a cell's membrane (transverse diffusion). Their existence was predicted in 1972 by Mark Bretscher, who also named them, to explain how an asymmetric phospholipid bilayer could be formed.".
- Flippase label "Flippase".
- Flippase sameAs Flipasa.
- Flippase sameAs Flipáza.
- Flippase sameAs Phospholipidtranslokatoren.
- Flippase sameAs Flipasa.
- Flippase sameAs Flipase.
- Flippase sameAs Flippasi.
- Flippase sameAs Flipazy.
- Flippase sameAs m.026hcww.
- Flippase sameAs Флиппазы.
- Flippase sameAs Flippas.
- Flippase sameAs Q420005.
- Flippase sameAs Q420005.
- Flippase wasDerivedFrom Flippase?oldid=681686198.
- Flippase isPrimaryTopicOf Flippase.