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- Fexaramine abstract "Fexaramine is an investigational compound which acts as an agonist of the farnesoid X receptor (FXR), which is a bile acid-activated nuclear receptor that controls bile-acid synthesis, conjugation and transport, as well as lipid metabolism through actions in the liver and intestine.The first publication about fexaramine in 2003 showed it has 100-fold greater affinity for FXR than natural compounds and described the genomic targets and binding site on FXR.When administered orally to mice, fexaramine produced selective actions through FXR receptors in the intestines. Consistent with the effects of other FXR agonist drugs, in a study in mice, oral fexaramine stimulated intestinal fibroblast growth factor 15 (FGF15) production and resulted in metabolic improvements. Intestinal tissue-specific actions of fexaramine were suggested to be a possible new approach for the treatment of obesity and metabolic syndrome. However it cannot be determined from these preliminary results in mice whether FXR agonism with fexaramine will produce weight loss in humans. There are no clinical trials of fexaramine planned in humans and therapy with such FXR agonists for obesity is only a theoretical approach.".
- Fexaramine casNumber "574013-66-4".
- Fexaramine chEBI "80003".
- Fexaramine drugbank "DB02545".
- Fexaramine iupacName "Methyl (E)-3-[3-[cyclohexanecarbonyl-[[4-[4-(dimethylamino)phenyl]phenyl]methyl]amino]phenyl]prop-2-enoate".
- Fexaramine pubchem "5326713".
- Fexaramine thumbnail Fexaramine.svg?width=300.
- Fexaramine wikiPageID "44974898".
- Fexaramine wikiPageLength "4171".
- Fexaramine wikiPageOutDegree "8".
- Fexaramine wikiPageRevisionID "677381069".
- Fexaramine wikiPageWikiLink Agonist.
- Fexaramine wikiPageWikiLink Category:Receptor_agonists.
- Fexaramine wikiPageWikiLink FGF15.
- Fexaramine wikiPageWikiLink Farnesoid_X_receptor.
- Fexaramine wikiPageWikiLink Human_gastrointestinal_tract.
- Fexaramine wikiPageWikiLink Intestine.
- Fexaramine wikiPageWikiLink Liver.
- Fexaramine wikiPageWikiLink Nuclear_receptor.
- Fexaramine wikiPageWikiLink File:1OSH.png.
- Fexaramine wikiPageWikiLinkText "Fexaramine".
- Fexaramine c "32".
- Fexaramine casNumber "574013".
- Fexaramine chebi "80003".
- Fexaramine chembl "192966".
- Fexaramine chemspiderid "4484057".
- Fexaramine drugbank "DB02545".
- Fexaramine h "36".
- Fexaramine hasPhotoCollection Fexaramine.
- Fexaramine inchi "1".
- Fexaramine inchikey "VLQTUNDJHLEFEQ-KGENOOAVSA-N".
- Fexaramine iupacName "Methyl -3-[3-[cyclohexanecarbonyl-[[4-[4-phenyl]phenyl]methyl]amino]phenyl]prop-2-enoate".
- Fexaramine iupharLigand "2744".
- Fexaramine kegg "15649.0".
- Fexaramine molecularWeight "496.64".
- Fexaramine n "2".
- Fexaramine o "3".
- Fexaramine pubchem "5326713".
- Fexaramine smiles "CNC1=CC=CC2=CC=CCNCC4CCCCC4".
- Fexaramine wikiPageUsesTemplate Template:Biochem-stub.
- Fexaramine wikiPageUsesTemplate Template:Clear.
- Fexaramine wikiPageUsesTemplate Template:Drugbox.
- Fexaramine wikiPageUsesTemplate Template:Nuclear_receptor_ligands.
- Fexaramine wikiPageUsesTemplate Template:Reflist.
- Fexaramine subject Category:Receptor_agonists.
- Fexaramine hypernym Compound.
- Fexaramine type ChemicalCompound.
- Fexaramine type ChemicalSubstance.
- Fexaramine type Drug.
- Fexaramine type ChemicalObject.
- Fexaramine type Thing.
- Fexaramine type Q8386.
- Fexaramine comment "Fexaramine is an investigational compound which acts as an agonist of the farnesoid X receptor (FXR), which is a bile acid-activated nuclear receptor that controls bile-acid synthesis, conjugation and transport, as well as lipid metabolism through actions in the liver and intestine.The first publication about fexaramine in 2003 showed it has 100-fold greater affinity for FXR than natural compounds and described the genomic targets and binding site on FXR.When administered orally to mice, fexaramine produced selective actions through FXR receptors in the intestines. ".
- Fexaramine label "Fexaramine".
- Fexaramine sameAs Fexaramina.
- Fexaramine sameAs m.012m87yt.
- Fexaramine sameAs Q19597241.
- Fexaramine sameAs Q19597241.
- Fexaramine wasDerivedFrom Fexaramine?oldid=677381069.
- Fexaramine depiction Fexaramine.svg.
- Fexaramine isPrimaryTopicOf Fexaramine.