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- Fertile_eunuch_syndrome abstract "The fertile eunuch syndrome is a cause of hypogonadotropic hypogonadism caused by a lutheinizing hormone deficiency. It is characterized by hypogonadism with spermatogenesis.Pasqualini and Bur published the first case of eunuchoidism with preserved spermatogenesis in 1950 in la Revista de la Asociación Médica Argentina.The hypoandrogenism with spermatogenesis syndrome included: (a) eunuchoidism, (b) testis with normal spermatogenesis and full volume, with mature spermatozoids in a high proportion of seminiferous tubes and undifferentiated and immature Leydig cells (c) full functional compensation through the administration of chorionic gonadotropin hormone, while hCG is administered (d) total urinary gonadotrophins within normal limits (e) this definition implies the normal activity of the pituitary and the absence of congenital malformations in general. In describing five other similar cases in 1953, Mc Cullagh & al coined the term fertile eunuch introducing it in the English literature. Unfortunately, this term is incorrect and should not be employed. Indeed, these patients are not really eunuchs. Moreover, as it will be explained later, they are not usually fertile if not treated.A first step in the understanding of the physiopathology of Pasqualini syndrome was the absence of Lutheinizing Hormone (LH) in plasma and urine of patients. The second breakthrough was the functional and genetic studies that validated the hypothesis of a functional deficit of LH in these men. Inactivating LH mutations will then also be described in some women. Different groups demonstrated in these cases a LH with varying degrees of immunological activity but biologically inactive in most of the patients, due to one or more inactivating mutations in the LHB gene. Finally, the full comprehension of Pasqualini syndrome allowed to reverse the hypoandrogenic phenotype and to restore fertility in these patients through the use of chorionic gonadotropin and the modern in-vitro fertility techniques".
- Fertile_eunuch_syndrome wikiPageID "44271012".
- Fertile_eunuch_syndrome wikiPageLength "5134".
- Fertile_eunuch_syndrome wikiPageOutDegree "27".
- Fertile_eunuch_syndrome wikiPageRevisionID "651601116".
- Fertile_eunuch_syndrome wikiPageWikiLink Androgen.
- Fertile_eunuch_syndrome wikiPageWikiLink Beta_Lutheinizing_Hormone_mutation.
- Fertile_eunuch_syndrome wikiPageWikiLink Category:Endocrine_gonad_disorders.
- Fertile_eunuch_syndrome wikiPageWikiLink Category:Gonadotropin-releasing_hormone_and_gonadotropins.
- Fertile_eunuch_syndrome wikiPageWikiLink Delayed_puberty.
- Fertile_eunuch_syndrome wikiPageWikiLink Estrogen.
- Fertile_eunuch_syndrome wikiPageWikiLink Follicle-stimulating_hormone.
- Fertile_eunuch_syndrome wikiPageWikiLink Gonad.
- Fertile_eunuch_syndrome wikiPageWikiLink Gonadotropin.
- Fertile_eunuch_syndrome wikiPageWikiLink Gonadotropin-releasing_hormone.
- Fertile_eunuch_syndrome wikiPageWikiLink Gonadotropin-releasing_hormone_insensitivity.
- Fertile_eunuch_syndrome wikiPageWikiLink Hypergonadotropic_hypogonadism.
- Fertile_eunuch_syndrome wikiPageWikiLink Hypogonadism.
- Fertile_eunuch_syndrome wikiPageWikiLink Hypogonadotropic_hypogonadism.
- Fertile_eunuch_syndrome wikiPageWikiLink Hypothalamic–pituitary–gonadal_axis.
- Fertile_eunuch_syndrome wikiPageWikiLink Hypothalamus.
- Fertile_eunuch_syndrome wikiPageWikiLink Infertility.
- Fertile_eunuch_syndrome wikiPageWikiLink Kallmann_syndrome.
- Fertile_eunuch_syndrome wikiPageWikiLink Luteinizing_hormone.
- Fertile_eunuch_syndrome wikiPageWikiLink Ovary.
- Fertile_eunuch_syndrome wikiPageWikiLink Pasqualini_Syndrome.
- Fertile_eunuch_syndrome wikiPageWikiLink Pituitary_gland.
- Fertile_eunuch_syndrome wikiPageWikiLink Sex_hormone.
- Fertile_eunuch_syndrome wikiPageWikiLink Sex_steroid.
- Fertile_eunuch_syndrome wikiPageWikiLink Spermatogenesis.
- Fertile_eunuch_syndrome wikiPageWikiLink Testicle.
- Fertile_eunuch_syndrome wikiPageWikiLinkText "Fertile eunuch syndrome".
- Fertile_eunuch_syndrome hasPhotoCollection Fertile_eunuch_syndrome.
- Fertile_eunuch_syndrome wikiPageUsesTemplate Template:Endocrine-disease-stub.
- Fertile_eunuch_syndrome wikiPageUsesTemplate Template:Endocrine_pathology.
- Fertile_eunuch_syndrome wikiPageUsesTemplate Template:Reflist.
- Fertile_eunuch_syndrome subject Category:Endocrine_gonad_disorders.
- Fertile_eunuch_syndrome subject Category:Gonadotropin-releasing_hormone_and_gonadotropins.
- Fertile_eunuch_syndrome hypernym Cause.
- Fertile_eunuch_syndrome type Disease.
- Fertile_eunuch_syndrome comment "The fertile eunuch syndrome is a cause of hypogonadotropic hypogonadism caused by a lutheinizing hormone deficiency.".
- Fertile_eunuch_syndrome label "Fertile eunuch syndrome".
- Fertile_eunuch_syndrome sameAs Zespół_płodnego_eunucha.
- Fertile_eunuch_syndrome sameAs m.0127fy_7.
- Fertile_eunuch_syndrome sameAs Q9390597.
- Fertile_eunuch_syndrome sameAs Q9390597.
- Fertile_eunuch_syndrome wasDerivedFrom Fertile_eunuch_syndrome?oldid=651601116.
- Fertile_eunuch_syndrome isPrimaryTopicOf Fertile_eunuch_syndrome.