Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/Factor_VIII> ?p ?o }
- Factor_VIII abstract "Factor VIII (FVIII) is an essential blood-clotting protein, also known as anti-hemophilic factor (AHF). In humans, factor VIII is encoded by the F8 gene. Defects in this gene results in hemophilia A, a recessive X-linked coagulation disorder. Factor VIII is produced in liver sinusoidal cells and endothelial cells outside of the liver throughout the body. This protein circulates in the bloodstream in an inactive form, bound to another molecule called von Willebrand factor, until an injury that damages blood vessels occurs. In response to injury, coagulation factor VIII is activated and separates from von Willebrand factor. The active protein (sometimes written as coagulation factor VIIIa) interacts with another coagulation factor called factor IX. This interaction sets off a chain of additional chemical reactions that form a blood clot.Factor VIII participates in blood coagulation; it is a cofactor for factor IXa which, in the presence of Ca2+ and phospholipids forms a complex that converts factor X to the activated form Xa. The factor VIII gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity.People with high levels of factor VIII are at increased risk for deep vein thrombosis and pulmonary embolism. Copper is a required cofactor for factor VIII and copper deficiency is known to decrease levels of factor VIII.".
- Factor_VIII entrezgene "2157".
- Factor_VIII wikiPageExternalLink coagulationfactorviii.php.
- Factor_VIII wikiPageExternalLink NBK1404.
- Factor_VIII wikiPageID "546073".
- Factor_VIII wikiPageLength "12250".
- Factor_VIII wikiPageOutDegree "59".
- Factor_VIII wikiPageRevisionID "680336632".
- Factor_VIII wikiPageWikiLink Aafact.
- Factor_VIII wikiPageWikiLink Bayer.
- Factor_VIII wikiPageWikiLink Blood_coagulation.
- Factor_VIII wikiPageWikiLink Blood_plasma.
- Factor_VIII wikiPageWikiLink Category:Acute_phase_proteins.
- Factor_VIII wikiPageWikiLink Category:Coagulation_system.
- Factor_VIII wikiPageWikiLink Category:Cofactors.
- Factor_VIII wikiPageWikiLink Category:Recombinant_proteins.
- Factor_VIII wikiPageWikiLink Coagulation.
- Factor_VIII wikiPageWikiLink Cofactor_(biochemistry).
- Factor_VIII wikiPageWikiLink Contaminated_haemophilia_blood_products.
- Factor_VIII wikiPageWikiLink Deep_vein_thrombosis.
- Factor_VIII wikiPageWikiLink Dominance_(genetics).
- Factor_VIII wikiPageWikiLink Edward_Shanbrom.
- Factor_VIII wikiPageWikiLink Edward_Tuddenham.
- Factor_VIII wikiPageWikiLink Endothelium.
- Factor_VIII wikiPageWikiLink Factor_8:_The_Arkansas_Prison_Blood_Scandal.
- Factor_VIII wikiPageWikiLink Factor_IX.
- Factor_VIII wikiPageWikiLink Factor_V.
- Factor_VIII wikiPageWikiLink Factor_X.
- Factor_VIII wikiPageWikiLink Factor_XIII.
- Factor_VIII wikiPageWikiLink Fibrin.
- Factor_VIII wikiPageWikiLink Food_and_Drug_Administration.
- Factor_VIII wikiPageWikiLink Gene.
- Factor_VIII wikiPageWikiLink Glycoprotein.
- Factor_VIII wikiPageWikiLink HIV.
- Factor_VIII wikiPageWikiLink Haemophilia.
- Factor_VIII wikiPageWikiLink Haemophilia_A.
- Factor_VIII wikiPageWikiLink Hemophilia_A.
- Factor_VIII wikiPageWikiLink Hemophiliac.
- Factor_VIII wikiPageWikiLink Hemostasis.
- Factor_VIII wikiPageWikiLink Hepatitis_B.
- Factor_VIII wikiPageWikiLink Hepatitis_C.
- Factor_VIII wikiPageWikiLink Hepatocyte.
- Factor_VIII wikiPageWikiLink Intron.
- Factor_VIII wikiPageWikiLink Liver.
- Factor_VIII wikiPageWikiLink Non-covalent_interactions.
- Factor_VIII wikiPageWikiLink Noncovalent_bonding.
- Factor_VIII wikiPageWikiLink Organ_transplant.
- Factor_VIII wikiPageWikiLink Organ_transplantation.
- Factor_VIII wikiPageWikiLink Phospholipid.
- Factor_VIII wikiPageWikiLink Polymer.
- Factor_VIII wikiPageWikiLink Protein.
- Factor_VIII wikiPageWikiLink Protein_C.
- Factor_VIII wikiPageWikiLink Proteolysis.
- Factor_VIII wikiPageWikiLink Pulmonary_embolism.
- Factor_VIII wikiPageWikiLink Ralph_Kekwick.
- Factor_VIII wikiPageWikiLink Recombinant_DNA.
- Factor_VIII wikiPageWikiLink Ryan_White.
- Factor_VIII wikiPageWikiLink Sinusoid_(blood_vessel).
- Factor_VIII wikiPageWikiLink Thrombin.
- Factor_VIII wikiPageWikiLink Thrombus.
- Factor_VIII wikiPageWikiLink Von_Willebrand_factor.
- Factor_VIII wikiPageWikiLink X_chromosome.
- Factor_VIII wikiPageWikiLinkText "Coagulation factor VIII".
- Factor_VIII wikiPageWikiLinkText "F8".
- Factor_VIII wikiPageWikiLinkText "Factor VIII".
- Factor_VIII wikiPageWikiLinkText "Factor_VIII#concentrate".
- Factor_VIII wikiPageWikiLinkText "VIII".
- Factor_VIII wikiPageWikiLinkText "VIIIa".
- Factor_VIII wikiPageWikiLinkText "anti-hemophilic factor".
- Factor_VIII wikiPageWikiLinkText "blood-clotting medication".
- Factor_VIII wikiPageWikiLinkText "contaminated blood products".
- Factor_VIII wikiPageWikiLinkText "factor VIII".
- Factor_VIII wikiPageWikiLinkText "factor VIII".
- Factor_VIII wikiPageWikiLinkText "factors VIII".
- Factor_VIII wikiPageWikiLinkText "rFVIII".
- Factor_VIII wikiPageWikiLinkText "recombinant clotting factor VIII".
- Factor_VIII hasPhotoCollection Factor_VIII.
- Factor_VIII requireManualInspection "no".
- Factor_VIII updateCitations "yes".
- Factor_VIII updatePage "yes".
- Factor_VIII updateProteinBox "yes".
- Factor_VIII updateSummary "no".
- Factor_VIII wikiPageUsesTemplate Template:Anchor.
- Factor_VIII wikiPageUsesTemplate Template:Coagulation.
- Factor_VIII wikiPageUsesTemplate Template:Hatnote.
- Factor_VIII wikiPageUsesTemplate Template:Main.
- Factor_VIII wikiPageUsesTemplate Template:MeshName.
- Factor_VIII wikiPageUsesTemplate Template:PBB.
- Factor_VIII wikiPageUsesTemplate Template:PBB_Controls.
- Factor_VIII wikiPageUsesTemplate Template:PBB_Further_reading.
- Factor_VIII wikiPageUsesTemplate Template:PDB_Gallery.
- Factor_VIII wikiPageUsesTemplate Template:Refbegin.
- Factor_VIII wikiPageUsesTemplate Template:Refend.
- Factor_VIII wikiPageUsesTemplate Template:Reflist.
- Factor_VIII subject Category:Acute_phase_proteins.
- Factor_VIII subject Category:Coagulation_system.
- Factor_VIII subject Category:Cofactors.
- Factor_VIII subject Category:Recombinant_proteins.
- Factor_VIII hypernym Protein.
- Factor_VIII type Biomolecule.