Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/FKBP52> ?p ?o }
Showing triples 1 to 72 of
72
with 100 triples per page.
- FKBP52 abstract "FK506-binding protein 4 is a protein that in humans is encoded by the FKBP4 gene.The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. This gene has been found to have multiple polyadenylation sites.This protein contains TPR repeats and has a PPlase domain.Recent research suggests that FKBP52 may play a role in preventing the Tau protein from turning pathogenic. This may prove significant for the development of new Alzheimer's drugs and for detecting the disease before the onset of clinical symptoms.".
- FKBP52 entrezgene "2288".
- FKBP52 wikiPageID "9432615".
- FKBP52 wikiPageLength "10498".
- FKBP52 wikiPageOutDegree "25".
- FKBP52 wikiPageRevisionID "661024186".
- FKBP52 wikiPageWikiLink Adeno-associated_virus.
- FKBP52 wikiPageWikiLink Alzheimers.
- FKBP52 wikiPageWikiLink Alzheimers_disease.
- FKBP52 wikiPageWikiLink B_cell.
- FKBP52 wikiPageWikiLink B_lymphocyte.
- FKBP52 wikiPageWikiLink FK506.
- FKBP52 wikiPageWikiLink FKBP5.
- FKBP52 wikiPageWikiLink GLMN.
- FKBP52 wikiPageWikiLink Gene.
- FKBP52 wikiPageWikiLink Gene_therapy.
- FKBP52 wikiPageWikiLink Glucocorticoid_receptor.
- FKBP52 wikiPageWikiLink Hsp70.
- FKBP52 wikiPageWikiLink Hsp90.
- FKBP52 wikiPageWikiLink Immunophilin.
- FKBP52 wikiPageWikiLink Immunophilins.
- FKBP52 wikiPageWikiLink Immunosuppressant.
- FKBP52 wikiPageWikiLink Immunosuppression.
- FKBP52 wikiPageWikiLink PPlase_domain.
- FKBP52 wikiPageWikiLink Prolyl_isomerase.
- FKBP52 wikiPageWikiLink Protein.
- FKBP52 wikiPageWikiLink Protein-protein_interaction.
- FKBP52 wikiPageWikiLink Protein_folding.
- FKBP52 wikiPageWikiLink Protein–protein_interaction.
- FKBP52 wikiPageWikiLink Rapamycin.
- FKBP52 wikiPageWikiLink Sirolimus.
- FKBP52 wikiPageWikiLink Steroid_hormone_receptor.
- FKBP52 wikiPageWikiLink T_cell.
- FKBP52 wikiPageWikiLink T_lymphocyte.
- FKBP52 wikiPageWikiLink Tacrolimus.
- FKBP52 wikiPageWikiLink Tau_protein.
- FKBP52 wikiPageWikiLink Tetratricopeptide.
- FKBP52 wikiPageWikiLink Vector_(molecular_biology).
- FKBP52 wikiPageWikiLinkText "FKBP52 - a functional antagonist to FKBP51 at corticoid receptors".
- FKBP52 wikiPageWikiLinkText "FKBP52".
- FKBP52 hasPhotoCollection FKBP52.
- FKBP52 requireManualInspection "no".
- FKBP52 summaryText "The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A , but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. This gene has been found to have multiple polyadenylation sites.".
- FKBP52 updateCitations "yes".
- FKBP52 updatePage "yes".
- FKBP52 updateProteinBox "yes".
- FKBP52 updateSummary "yes".
- FKBP52 wikiPageUsesTemplate Template:Gene-12-stub.
- FKBP52 wikiPageUsesTemplate Template:Geometric_isomerases.
- FKBP52 wikiPageUsesTemplate Template:MeshName.
- FKBP52 wikiPageUsesTemplate Template:PBB.
- FKBP52 wikiPageUsesTemplate Template:PBB_Controls.
- FKBP52 wikiPageUsesTemplate Template:PBB_Further_reading.
- FKBP52 wikiPageUsesTemplate Template:PBB_Summary.
- FKBP52 wikiPageUsesTemplate Template:PDB_Gallery.
- FKBP52 wikiPageUsesTemplate Template:Refbegin.
- FKBP52 wikiPageUsesTemplate Template:Refend.
- FKBP52 wikiPageUsesTemplate Template:Reflist.
- FKBP52 hypernym Protein.
- FKBP52 type Biomolecule.
- FKBP52 type Protein.
- FKBP52 type Thing.
- FKBP52 type Q206229.
- FKBP52 type Q8054.
- FKBP52 comment "FK506-binding protein 4 is a protein that in humans is encoded by the FKBP4 gene.The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin.".
- FKBP52 label "FKBP52".
- FKBP52 sameAs FKBP52.
- FKBP52 sameAs m.0288rl5.
- FKBP52 sameAs Q5426019.
- FKBP52 sameAs Q5426019.
- FKBP52 wasDerivedFrom FKBP52?oldid=661024186.
- FKBP52 isPrimaryTopicOf FKBP52.