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- FGD1 abstract "FYVE, RhoGEF and PH domain-containing protein 1 (FGD1) also known as faciogenital dysplasia 1 protein (FGDY), zinc finger FYVE domain-containing protein 3 (ZFYVE3), or Rho/Rac guanine nucleotide exchange factor FGD1 (Rho/Rac GEF) is a protein that in humans is encoded by the FGD1 gene that lies on the X chromosome. Orthologs of the FGD1 gene are found in dog, cow, mouse, rat, and zebrafish, and also budding yeast and C. elegans. It is a member of the FYVE, RhoGEF and PH domain containing family.FGD1 is a guanine-nucleotide exchange factor (GEF) that can activate the Rho GTPase Cdc42. It localizes preferentially to the trans-Golgi network (TGN) of mammalian cells and regulates, for example, the secretory transport of bone-specific proteins from the Golgi complex. Thus Cdc42 and FGD1 regulate secretory membrane trafficking that occurs especially during bone growth and mineralization in humans. FGD1 promotes nucleotide exchange on the GTPase Cdc42, a key player in the establishment of cell polarity in all eukaryotic cells. The GEF activity of FGD1, which activates Cdc42, is harbored in its DH domain and causes the formation of filopodia, enabling the cells to migrate. FGD1 also activates the c-Jun N-terminal kinase (JNK) signaling cascade, important in cell differentiation and apoptosis. It also promotes the transition through G1 during the cell cycle and causes tumorgenic transformation of NIH/3T3 fibroblasts.The FGD1 gene is located on the short arm of the X-chromosome and is essential for normal mammalian embryonic development. Mice embryos that carried experimentally introduced mutations in the FGD1 gene had skeletal abnormalities affecting bone size, cartilage growth, vertebrae formation and distal extremities. These severe phenotypes are consistent with a lack of Cdc42 activity, as it controls membrane traffic as well as the organization of the actin cytoskeleton. Mutations in the FGD1 gene that cause the production of non-functional proteins are responsible for the severe phenotype of the X-linked disorder faciogential dysplasia (FGDY), also called Aarskog-Scott syndrome.".
- FGD1 entrezgene "2245".
- FGD1 wikiPageID "12044577".
- FGD1 wikiPageLength "12495".
- FGD1 wikiPageOutDegree "29".
- FGD1 wikiPageRevisionID "598598060".
- FGD1 wikiPageWikiLink 3T3_cells.
- FGD1 wikiPageWikiLink Aarskog-Scott_syndrome.
- FGD1 wikiPageWikiLink Aarskog–Scott_syndrome.
- FGD1 wikiPageWikiLink 3_complex.
- FGD1 wikiPageWikiLink C-Jun_N-terminal_kinase.
- FGD1 wikiPageWikiLink C-Jun_N-terminal_kinases.
- FGD1 wikiPageWikiLink CDC42.
- FGD1 wikiPageWikiLink Caenorhabditis_elegans.
- FGD1 wikiPageWikiLink Category:Human_proteins.
- FGD1 wikiPageWikiLink Cortactin.
- FGD1 wikiPageWikiLink EEA1.
- FGD1 wikiPageWikiLink Eukaryote.
- FGD1 wikiPageWikiLink FYVE,_RhoGEF_and_PH_domain_containing.
- FGD1 wikiPageWikiLink FYVE_domain.
- FGD1 wikiPageWikiLink Fab1.
- FGD1 wikiPageWikiLink Filopodia.
- FGD1 wikiPageWikiLink Gene.
- FGD1 wikiPageWikiLink Golgi_apparatus.
- FGD1 wikiPageWikiLink Guanine-nucleotide_exchange_factor.
- FGD1 wikiPageWikiLink Guanine_nucleotide_exchange_factor.
- FGD1 wikiPageWikiLink Homology_(biology).
- FGD1 wikiPageWikiLink PH_domain.
- FGD1 wikiPageWikiLink PIKFYVE.
- FGD1 wikiPageWikiLink Phosphatidylinositol_3-phosphate.
- FGD1 wikiPageWikiLink Pleckstrin_homology_domain.
- FGD1 wikiPageWikiLink Protein.
- FGD1 wikiPageWikiLink RhoGEF_domain.
- FGD1 wikiPageWikiLink Vac1.
- FGD1 wikiPageWikiLink YOTB.
- FGD1 wikiPageWikiLinkText "FGD1".
- FGD1 hasPhotoCollection FGD1.
- FGD1 wikiPageUsesTemplate Template:GTP-binding_protein_regulators.
- FGD1 wikiPageUsesTemplate Template:PBB.
- FGD1 wikiPageUsesTemplate Template:Reflist.
- FGD1 subject Category:Human_proteins.
- FGD1 hypernym Protein.
- FGD1 type Biomolecule.
- FGD1 type Protein.
- FGD1 type Thing.
- FGD1 type Q206229.
- FGD1 type Q8054.
- FGD1 comment "FYVE, RhoGEF and PH domain-containing protein 1 (FGD1) also known as faciogenital dysplasia 1 protein (FGDY), zinc finger FYVE domain-containing protein 3 (ZFYVE3), or Rho/Rac guanine nucleotide exchange factor FGD1 (Rho/Rac GEF) is a protein that in humans is encoded by the FGD1 gene that lies on the X chromosome. Orthologs of the FGD1 gene are found in dog, cow, mouse, rat, and zebrafish, and also budding yeast and C. elegans.".
- FGD1 label "FGD1".
- FGD1 sameAs m.03gy7p8.
- FGD1 sameAs Q5425457.
- FGD1 sameAs Q5425457.
- FGD1 wasDerivedFrom FGD1?oldid=598598060.
- FGD1 isPrimaryTopicOf FGD1.