Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/FE_200665> ?p ?o }
Showing triples 1 to 59 of
59
with 100 triples per page.
- FE_200665 abstract "FE 200665 (H-D-Phe-D-Phe-D-Nle-D-Arg-NH-4-Picolyl), also known as CR665, is an all D-amino acid peptide that acts as a peripherally restricted κ-opioid receptor agonist. The selectivity for FE 200665 is 1/16,900/84,600 for the human κ, μ, and δ opioid receptors, respectively. The dose of FE 200665 required to produce motor impairment (measure of CNS penetration) was 548 times higher than the dose required for antinociceptive activity. It is being developed for use by Cara Therapeutics under the code CR665.A small, double blind study was done in healthy humans to determine the analgesic effects. CR665 was dosed at 0.36 mg/kg I.V., and was compared to 15 mg oxycodone orally. CR665 had analgesic effects on visceral pain, but produced a hyperalgesic response in a skin pinch test.".
- FE_200665 iupacName "(R)-2-((R)-2-((R)-2-amino-3-phenylpropanamido)-3-phenylpropanamido)-N-((R)-5-guanidino-1-oxo-1-((pyridin-4-ylmethyl)amino)pentan-2-yl)hexanamide".
- FE_200665 thumbnail FE_200665.svg?width=300.
- FE_200665 wikiPageID "34099437".
- FE_200665 wikiPageLength "3019".
- FE_200665 wikiPageOutDegree "11".
- FE_200665 wikiPageRevisionID "670415415".
- FE_200665 wikiPageWikiLink Antinociceptive.
- FE_200665 wikiPageWikiLink Category:Kappa_agonists.
- FE_200665 wikiPageWikiLink Category:Opioids.
- FE_200665 wikiPageWikiLink Central_nervous_system.
- FE_200665 wikiPageWikiLink Delta_Opioid_receptor.
- FE_200665 wikiPageWikiLink Hyperalgesia.
- FE_200665 wikiPageWikiLink Intravenous_injection.
- FE_200665 wikiPageWikiLink Intravenous_therapy.
- FE_200665 wikiPageWikiLink Mu_Opioid_receptor.
- FE_200665 wikiPageWikiLink Nociception.
- FE_200665 wikiPageWikiLink Oxycodone.
- FE_200665 wikiPageWikiLink Peptide.
- FE_200665 wikiPageWikiLink Δ-opioid_receptor.
- FE_200665 wikiPageWikiLink Κ-opioid_receptor.
- FE_200665 wikiPageWikiLink Μ-opioid_receptor.
- FE_200665 wikiPageWikiLinkText "FE 200665 (CR665)".
- FE_200665 wikiPageWikiLinkText "FE 200665".
- FE_200665 hasPhotoCollection FE_200665.
- FE_200665 imagefile "FE 200665.svg".
- FE_200665 imagesize "250".
- FE_200665 iupacname "-2".
- FE_200665 othernames "CR 665; JNJ 38488502".
- FE_200665 wikiPageUsesTemplate Template:Chembox.
- FE_200665 wikiPageUsesTemplate Template:Nervous-system-drug-stub.
- FE_200665 wikiPageUsesTemplate Template:Opioidergics.
- FE_200665 wikiPageUsesTemplate Template:Reflist.
- FE_200665 subject Category:Kappa_agonists.
- FE_200665 subject Category:Opioids.
- FE_200665 type Article.
- FE_200665 type ChemicalCompound.
- FE_200665 type ChemicalSubstance.
- FE_200665 type Drug.
- FE_200665 type Agonist.
- FE_200665 type Alkaloid.
- FE_200665 type Analgesic.
- FE_200665 type Article.
- FE_200665 type Chemical.
- FE_200665 type Drug.
- FE_200665 type Opioid.
- FE_200665 type ChemicalObject.
- FE_200665 type Thing.
- FE_200665 type Q11173.
- FE_200665 comment "FE 200665 (H-D-Phe-D-Phe-D-Nle-D-Arg-NH-4-Picolyl), also known as CR665, is an all D-amino acid peptide that acts as a peripherally restricted κ-opioid receptor agonist. The selectivity for FE 200665 is 1/16,900/84,600 for the human κ, μ, and δ opioid receptors, respectively. The dose of FE 200665 required to produce motor impairment (measure of CNS penetration) was 548 times higher than the dose required for antinociceptive activity.".
- FE_200665 label "FE 200665".
- FE_200665 sameAs m.0hr56gs.
- FE_200665 sameAs FE_200665.
- FE_200665 sameAs FE_200665.
- FE_200665 sameAs Q5425398.
- FE_200665 sameAs Q5425398.
- FE_200665 wasDerivedFrom FE_200665?oldid=670415415.
- FE_200665 depiction FE_200665.svg.
- FE_200665 isPrimaryTopicOf FE_200665.