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- FAS-AS1 abstract "In molecular biology, FAS antisense RNA (non-protein coding), also known as FAS-AS1 or SAF, is a long non-coding RNA. In humans it is located on chromosome 10. In humans it is transcribed from the opposite strand of intron 1 of the FAS gene. It may regulate the expression of some isoforms of FAS. It may also play a role in the regulation of FAS-mediated apoptosis. Recently it has been shown be sehgal et al that the alternative splicing of Fas in lymphomas is tightly regulated by a long-noncoding RNA corresponding to an antisense transcript of Fas (FAS-AS1). Levels of FAS-AS1 correlate inversely with production of sFas, and FAS-AS1 binding to the RBM5 inhibits RBM5-mediated exon 6 skipping. EZH2, often mutated or overexpressed in lymphomas, hyper-methylates the FAS-AS1 promoter and represses the FAS-AS1 expression. EZH2-mediated repression of FAS-AS1 promoter can be released by DZNeP (3-Deazaneplanocin A) or overcome by ectopic expression of FAS-AS1, both of which increase levels of FAS-AS1 and correspondingly decrease expression of sFas. Treatment with Bruton’s tyrosine kinase inhibitor or EZH2 knockdown decreases the levels of EZH2, RBM5 and sFas, thereby enhancing Fas-mediated apoptosis. This is the first report showing functional regulation of Fas repression by its antisense RNA. Our results reveal new therapeutic targets in lymphomas and provide a rationale for the use of EZH2 inhibitors or ibrutinib in combination with chemotherapeutic agents that recruit Fas for effective cell killing.".
- FAS-AS1 entrezgene "100302740".
- FAS-AS1 wikiPageID "32942431".
- FAS-AS1 wikiPageLength "2648".
- FAS-AS1 wikiPageOutDegree "9".
- FAS-AS1 wikiPageRevisionID "656889769".
- FAS-AS1 wikiPageWikiLink Apoptosis.
- FAS-AS1 wikiPageWikiLink Category:Non-coding_RNA.
- FAS-AS1 wikiPageWikiLink Chromosome_10.
- FAS-AS1 wikiPageWikiLink Chromosome_10_(human).
- FAS-AS1 wikiPageWikiLink Fas_receptor.
- FAS-AS1 wikiPageWikiLink Intron.
- FAS-AS1 wikiPageWikiLink Isoforms.
- FAS-AS1 wikiPageWikiLink Long_non-coding_RNA.
- FAS-AS1 wikiPageWikiLink Long_noncoding_RNA.
- FAS-AS1 wikiPageWikiLink Protein_isoform.
- FAS-AS1 wikiPageWikiLink Transcription_(genetics).
- FAS-AS1 wikiPageWikiLinkText "FAS-AS1".
- FAS-AS1 hasPhotoCollection FAS-AS1.
- FAS-AS1 wikiPageUsesTemplate Template:PBB.
- FAS-AS1 wikiPageUsesTemplate Template:PDB_Gallery.
- FAS-AS1 wikiPageUsesTemplate Template:Reflist.
- FAS-AS1 subject Category:Non-coding_RNA.
- FAS-AS1 hypernym RNA.
- FAS-AS1 type Biomolecule.
- FAS-AS1 type Protein.
- FAS-AS1 type Thing.
- FAS-AS1 type Q206229.
- FAS-AS1 type Q8054.
- FAS-AS1 comment "In molecular biology, FAS antisense RNA (non-protein coding), also known as FAS-AS1 or SAF, is a long non-coding RNA. In humans it is located on chromosome 10. In humans it is transcribed from the opposite strand of intron 1 of the FAS gene. It may regulate the expression of some isoforms of FAS. It may also play a role in the regulation of FAS-mediated apoptosis.".
- FAS-AS1 label "FAS-AS1".
- FAS-AS1 sameAs m.011vn24z.
- FAS-AS1 sameAs Q5424468.
- FAS-AS1 sameAs Q5424468.
- FAS-AS1 wasDerivedFrom FAS-AS1?oldid=656889769.
- FAS-AS1 isPrimaryTopicOf FAS-AS1.