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- F-15,599 abstract "F-15,599, also known as NLX-101, is a very potent and highly selective 5-HT1A receptor full agonist. It displays functional selectivity (also known as "biased agonism") by strongly activating 5-HT1A receptors in the postsynaptic prefrontal cortex while having little effect on somatodendritic autoreceptors in the raphe nucleus. As a result, it has been touted as a preferential postsynaptic 5-HT1A receptor agonist and has been investigated as a novel potential antidepressant.In cognitive tests in rodent, F-15,599 attenuates memory deficits elicited by the NMDA receptor antagonist PCP, suggesting that it may improve cognitive function in disorders such as schizophrenia.A subsequent study showed that F-15,599 reduces breathing irregularity and apneas observed in mice with mutations of the MeCP2 gene. Dysruption of MeCP2 gene expression underlies Rett syndrome, a debilitating neurodevelopmental orphan disease.F-15,599 was discovered and initially developed by Pierre Fabre Médicament, a French pharmaceuticals company. In September 2013, F-15,599 was out-licensed to Neurolixis, a California-based biotechnology company. Neurolixis announced that it intends to re-purpose F-15,599 for the treatment of Rett syndrome. and obtained Orphan Drug designation from the United States Food and Drug Administration (FDA) and from the European Commission for this indication.Researchers at the University of Bristol are investigating the activity of F-15599 in animal models of Rett Syndrome, with support from the International Rett Syndrome Foundation. In June 2015, the Rett Syndrome Research Trust awarded a grant to Neurolixis to advance F-15599 to clinical development.".
- F-15,599 iupacName "3-chloro-4-fluorophenyl-[4-fluoro-4-[[(5-methylpyrimidin-2-ylmethyl)amino]methyl]piperidin-1-yl]methanone".
- F-15,599 pubchem "11741361".
- F-15,599 thumbnail F-15599-structure.png?width=300.
- F-15,599 wikiPageID "26612429".
- F-15,599 wikiPageLength "6026".
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- F-15,599 wikiPageWikiLink 5-HT1A_receptor.
- F-15,599 wikiPageWikiLink Agonist.
- F-15,599 wikiPageWikiLink Antidepressant.
- F-15,599 wikiPageWikiLink Autoreceptor.
- F-15,599 wikiPageWikiLink Befiradol.
- F-15,599 wikiPageWikiLink Binding_selectivity.
- F-15,599 wikiPageWikiLink Category:Amides.
- F-15,599 wikiPageWikiLink Category:Amines.
- F-15,599 wikiPageWikiLink Category:Chloroarenes.
- F-15,599 wikiPageWikiLink Category:Organofluorides.
- F-15,599 wikiPageWikiLink Category:Piperidines.
- F-15,599 wikiPageWikiLink Category:Pyrimidines.
- F-15,599 wikiPageWikiLink Chemical_synapse.
- F-15,599 wikiPageWikiLink Eptapirone.
- F-15,599 wikiPageWikiLink Food_and_Drug_Administration.
- F-15,599 wikiPageWikiLink Full_agonist.
- F-15,599 wikiPageWikiLink Functional_selectivity.
- F-15,599 wikiPageWikiLink Laboratoires_Pierre_Fabre.
- F-15,599 wikiPageWikiLink Neurolixis.
- F-15,599 wikiPageWikiLink Orphan_Drug.
- F-15,599 wikiPageWikiLink Orphan_disease.
- F-15,599 wikiPageWikiLink Orphan_drug.
- F-15,599 wikiPageWikiLink Pierre_Fabre_Group.
- F-15,599 wikiPageWikiLink Postsynaptic.
- F-15,599 wikiPageWikiLink Potency_(pharmacology).
- F-15,599 wikiPageWikiLink Prefrontal_cortex.
- F-15,599 wikiPageWikiLink Raphe_nuclei.
- F-15,599 wikiPageWikiLink Raphe_nucleus.
- F-15,599 wikiPageWikiLink Rare_disease.
- F-15,599 wikiPageWikiLink Rett_syndrome.
- F-15,599 wikiPageWikiLink Somatodendritic.
- F-15,599 wikiPageWikiLink University_of_Bristol.
- F-15,599 wikiPageWikiLinkText "F-15,599".
- F-15,599 c "19".
- F-15,599 chemspiderid "9916065".
- F-15,599 cl "1".
- F-15,599 f "2".
- F-15,599 h "22".
- F-15,599 hasPhotoCollection F-15,599.
- F-15,599 inchi "1".
- F-15,599 inchikey "WAAXKNFGOFTGLP-UHFFFAOYAK".
- F-15,599 iupacName "3".
- F-15,599 iupharLigand "3924".
- F-15,599 legalStatus "Uncontrolled".
- F-15,599 molecularWeight "395.854".
- F-15,599 n "4".
- F-15,599 o "1".
- F-15,599 pubchem "11741361".
- F-15,599 routesOfAdministration "Oral".
- F-15,599 smiles "Cc3cncCNCCCCN2Ccccc1F".
- F-15,599 stdinchi "1".
- F-15,599 stdinchikey "WAAXKNFGOFTGLP-UHFFFAOYSA-N".
- F-15,599 verifiedfields "changed".
- F-15,599 verifiedrevid "451554460".
- F-15,599 watchedfields "changed".
- F-15,599 wikiPageUsesTemplate Template:Antidepressants.
- F-15,599 wikiPageUsesTemplate Template:Anxiolytics.
- F-15,599 wikiPageUsesTemplate Template:Drugbox.
- F-15,599 wikiPageUsesTemplate Template:Reflist.
- F-15,599 wikiPageUsesTemplate Template:Serotonergics.
- F-15,599 subject Category:Amides.
- F-15,599 subject Category:Amines.
- F-15,599 subject Category:Chloroarenes.
- F-15,599 subject Category:Organofluorides.
- F-15,599 subject Category:Piperidines.
- F-15,599 subject Category:Pyrimidines.
- F-15,599 type ChemicalSubstance.
- F-15,599 type Drug.
- F-15,599 type ChemicalObject.
- F-15,599 type Thing.
- F-15,599 type Q8386.
- F-15,599 comment "F-15,599, also known as NLX-101, is a very potent and highly selective 5-HT1A receptor full agonist. It displays functional selectivity (also known as "biased agonism") by strongly activating 5-HT1A receptors in the postsynaptic prefrontal cortex while having little effect on somatodendritic autoreceptors in the raphe nucleus.".
- F-15,599 label "F-15,599".
- F-15,599 sameAs m.0bh7q49.
- F-15,599 sameAs F-15,599.
- F-15,599 sameAs F-15,599.
- F-15,599 sameAs F-15,599.
- F-15,599 sameAs Q5423588.
- F-15,599 sameAs Q5423588.
- F-15,599 wasDerivedFrom F-15,599?oldid=673923706.
- F-15,599 depiction F-15599-structure.png.
- F-15,599 isPrimaryTopicOf F-15,599.