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- Extrachromosomal_array abstract "An extrachromosomal array is a method for mosaic analysis in genetics. It is a cosmid, and contains two functioning (wild-type) closely linked genes: a gene of interest and a mosaic marker. Such an array is injected into germ line cells, which already contain mutant (specifically, loss of function) alleles of all three genes in their chromosomal DNA. The cosmid, which is not packed correctly during mitosis, is occasionally present in only one daughter cell following cell division. The daughter cell containing the array expresses the gene of interest; the cell lacking the array does not.The mosaic marker is a gene which exhibits a visible phenotype change between the functioning and non-functioning alleles. For example, ncl-1, located in chromosomal DNA, exhibits a larger nucleolus than the wild-type allele, which is in the array. Thus, cells which exhibit larger nucleoli have usually not retained the extrachromosomal array.The gene of interest is the target of the mosaic analysis. Cells lacking the extrachromosomal array also lack the functional gene of interest. Cells which develop normally without the array do not require the gene of interest for normal function. Cells which do not develop normally are said to require the gene. In this way, those cell lineages which require a specific gene can be identified.Extrachromosomal arrays replace an earlier technique involving a duplicated piece of chromosome called a free duplication. The latter technique required that the gene of interest and the mosaic marker be closely linked on the duplication; the former allows free choice of mosaic marker and target gene.".
- Extrachromosomal_array wikiPageID "14445573".
- Extrachromosomal_array wikiPageLength "2050".
- Extrachromosomal_array wikiPageOutDegree "13".
- Extrachromosomal_array wikiPageRevisionID "456833642".
- Extrachromosomal_array wikiPageWikiLink Allele.
- Extrachromosomal_array wikiPageWikiLink Alleles.
- Extrachromosomal_array wikiPageWikiLink Category:Genetics.
- Extrachromosomal_array wikiPageWikiLink Chromosome.
- Extrachromosomal_array wikiPageWikiLink Cosmid.
- Extrachromosomal_array wikiPageWikiLink Gene.
- Extrachromosomal_array wikiPageWikiLink Genes.
- Extrachromosomal_array wikiPageWikiLink Genetics.
- Extrachromosomal_array wikiPageWikiLink Germ_line.
- Extrachromosomal_array wikiPageWikiLink Germline.
- Extrachromosomal_array wikiPageWikiLink Loss_of_function.
- Extrachromosomal_array wikiPageWikiLink Mitosis.
- Extrachromosomal_array wikiPageWikiLink Mosaic_(genetics).
- Extrachromosomal_array wikiPageWikiLink Mosaic_analysis.
- Extrachromosomal_array wikiPageWikiLink Mutation.
- Extrachromosomal_array wikiPageWikiLink Nucleolus.
- Extrachromosomal_array wikiPageWikiLink Phenotype.
- Extrachromosomal_array wikiPageWikiLink Wild-type.
- Extrachromosomal_array wikiPageWikiLink Wild_type.
- Extrachromosomal_array hasPhotoCollection Extrachromosomal_array.
- Extrachromosomal_array wikiPageUsesTemplate Template:Genetics-stub.
- Extrachromosomal_array wikiPageUsesTemplate Template:Orphan.
- Extrachromosomal_array subject Category:Genetics.
- Extrachromosomal_array hypernym Method.
- Extrachromosomal_array type Article.
- Extrachromosomal_array type Software.
- Extrachromosomal_array type Article.
- Extrachromosomal_array comment "An extrachromosomal array is a method for mosaic analysis in genetics. It is a cosmid, and contains two functioning (wild-type) closely linked genes: a gene of interest and a mosaic marker. Such an array is injected into germ line cells, which already contain mutant (specifically, loss of function) alleles of all three genes in their chromosomal DNA. The cosmid, which is not packed correctly during mitosis, is occasionally present in only one daughter cell following cell division.".
- Extrachromosomal_array label "Extrachromosomal array".
- Extrachromosomal_array sameAs m.03d3s3m.
- Extrachromosomal_array sameAs Q5422181.
- Extrachromosomal_array sameAs Q5422181.
- Extrachromosomal_array wasDerivedFrom Extrachromosomal_array?oldid=456833642.
- Extrachromosomal_array isPrimaryTopicOf Extrachromosomal_array.