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- Exelixis abstract "Exelixis is a genomics-based drug discovery company located in South San Francisco, Ca., and the producer of Cometriq, a treatment approved by the U.S. Food and Drug Administration (FDA) for medullary thyroid cancer with clinical activity in several other types of metastatic cancer. It works on the development of anti-cancer therapies. Exelixis has several compounds in various stages of FDA approval including : XL147 that targets phosphoinositide-3 kinase (PI3K); and XL765, which targets PI3K and mTOR, kinases in the PI3K signaling pathway. XL880 (foretinib)The company also has various compounds in phase 1 clinical trials, including XL518 or GDC0973, a small molecule inhibitor of the MEK. Co-developed with Roche. XL228, which targets insulin-like growth factor type 1 receptor, an RTK in a range of human tumors; XL139 that targets Hedgehog; XL413, a small molecule inhibitor of the serine-threonine kinase CDC7; XL888, a synthetic inhibitor of HSP90, a chaperone protein that promotes the activity and stability of a range of regulatory proteins, including kinases.Its lead compound, XL184, has been approved for treatment of medullary thyroid cancer and is currently in a number of clinical trials for prostate, ovarian, brain, melanoma, breast, non-small cell lung, hepatocellular, kidney. During its trial for the treatment of medullary thyroid cancer, XL184 was designated orphan drug status by the FDA and given the generic name, cabozantinib. Cabozantinib is an inhibitor of the tyrosine kinases Met and VEGFR2, and has been shown to abrogate tumor growth, metastasis, and angiogenesis.".
- Exelixis foundingYear "1994".
- Exelixis industry Biotechnology.
- Exelixis location South_San_Francisco,_California.
- Exelixis location United_States.
- Exelixis type Public_company.
- Exelixis wikiPageExternalLink www.exelixis.com.
- Exelixis wikiPageExternalLink www.exelixis.com.
- Exelixis wikiPageID "1302007".
- Exelixis wikiPageLength "3071".
- Exelixis wikiPageOutDegree "35".
- Exelixis wikiPageRevisionID "653145026".
- Exelixis wikiPageWikiLink ACT_Biotech_Inc.
- Exelixis wikiPageWikiLink Biotechnology.
- Exelixis wikiPageWikiLink C-Met.
- Exelixis wikiPageWikiLink CDC7.
- Exelixis wikiPageWikiLink Cabozantinib.
- Exelixis wikiPageWikiLink Category:Biotechnology_companies_of_the_United_States.
- Exelixis wikiPageWikiLink Category:Companies_in_the_NASDAQ_Biotechnology_Index.
- Exelixis wikiPageWikiLink Category:Companies_listed_on_NASDAQ.
- Exelixis wikiPageWikiLink Cell_division_cycle_7-related_protein_kinase.
- Exelixis wikiPageWikiLink Cobimetinib.
- Exelixis wikiPageWikiLink Cometriq.
- Exelixis wikiPageWikiLink File:Exilixis_logo.PNG.
- Exelixis wikiPageWikiLink Food_and_Drug_Administration.
- Exelixis wikiPageWikiLink Foretinib.
- Exelixis wikiPageWikiLink GDC0973.
- Exelixis wikiPageWikiLink Genomics.
- Exelixis wikiPageWikiLink HSP90.
- Exelixis wikiPageWikiLink Hsp90.
- Exelixis wikiPageWikiLink Insulin-like_growth_factor_type_1_receptor.
- Exelixis wikiPageWikiLink Kinase_insert_domain_receptor.
- Exelixis wikiPageWikiLink MEK.
- Exelixis wikiPageWikiLink MTOR.
- Exelixis wikiPageWikiLink Mechanistic_target_of_rapamycin.
- Exelixis wikiPageWikiLink Medullary_thyroid_cancer.
- Exelixis wikiPageWikiLink Orphan_drug.
- Exelixis wikiPageWikiLink PI3K.
- Exelixis wikiPageWikiLink PI3K_inhibitor.
- Exelixis wikiPageWikiLink Phosphoinositide_3-kinase.
- Exelixis wikiPageWikiLink Phosphoinositide_3-kinase_inhibitor.
- Exelixis wikiPageWikiLink Public_company.
- Exelixis wikiPageWikiLink South_San_Francisco,_California.
- Exelixis wikiPageWikiLink USA.
- Exelixis wikiPageWikiLink United_States.
- Exelixis wikiPageWikiLink XL139.
- Exelixis wikiPageWikiLink XL147.
- Exelixis wikiPageWikiLink XL184.
- Exelixis wikiPageWikiLink XL228.
- Exelixis wikiPageWikiLink XL518.
- Exelixis wikiPageWikiLink XL765.
- Exelixis wikiPageWikiLink XL888.
- Exelixis wikiPageWikiLinkText "Exelixis".
- Exelixis companySlogan "A Better Way to Better Medicine".
- Exelixis foundation "1994".
- Exelixis hasPhotoCollection Exelixis.
- Exelixis homepage www.exelixis.com.
- Exelixis industry Biotechnology.
- Exelixis keyPeople "Frank Karbe, CFO".
- Exelixis keyPeople "Gisela M. Schwab, Executive Vice President and Chief Medical Officer".
- Exelixis keyPeople "Lupe M. Rivera, Senior Vice President, Operations".
- Exelixis keyPeople "Michael Morrissey, President, Research and Development".
- Exelixis keyPeople "Pamela A. Simonton, Executive Vice President and General Counsel".
- Exelixis keyPeople "Peter Lamb, Senior Vice President, Discovery Research and Chief Scientific Officer".
- Exelixis location South_San_Francisco,_California.
- Exelixis location USA.
- Exelixis location United_States.
- Exelixis logo "220".
- Exelixis name "Exelixis".
- Exelixis type Public_company.
- Exelixis wikiPageUsesTemplate Template:Commons_category.
- Exelixis wikiPageUsesTemplate Template:Infobox_company.
- Exelixis wikiPageUsesTemplate Template:Med-company-stub.
- Exelixis wikiPageUsesTemplate Template:Official_website.
- Exelixis wikiPageUsesTemplate Template:Refimprove.
- Exelixis wikiPageUsesTemplate Template:Reflist.
- Exelixis subject Category:Biotechnology_companies_of_the_United_States.
- Exelixis subject Category:Companies_in_the_NASDAQ_Biotechnology_Index.
- Exelixis subject Category:Companies_listed_on_NASDAQ.
- Exelixis hypernym Company.
- Exelixis type Agent.
- Exelixis type Company.
- Exelixis type Organisation.
- Exelixis type Company.
- Exelixis type Organization.
- Exelixis type Agent.
- Exelixis type SocialPerson.
- Exelixis type Thing.
- Exelixis type Q43229.
- Exelixis comment "Exelixis is a genomics-based drug discovery company located in South San Francisco, Ca., and the producer of Cometriq, a treatment approved by the U.S. Food and Drug Administration (FDA) for medullary thyroid cancer with clinical activity in several other types of metastatic cancer. It works on the development of anti-cancer therapies.".
- Exelixis label "Exelixis".
- Exelixis sameAs m.04r68_.
- Exelixis sameAs Q5419989.
- Exelixis sameAs Q5419989.
- Exelixis wasDerivedFrom Exelixis?oldid=653145026.
- Exelixis homepage www.exelixis.com.
- Exelixis isPrimaryTopicOf Exelixis.
- Exelixis name "Exelixis".