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- Erythropoietin_in_neuroprotection abstract "Erythropoietin in neuroprotection is the use of the glycoprotein erythropoietin (Epo) for neuroprotection. Epo controls erythropoiesis, or red blood cell production.Erythropoietin and its receptor are both present in the central nervous system with erythropoietin alpha capable of crossing the blood brain barrier via active transport. The presence of Epo within the spinal fluid of infants and the expression of Epo-R in the spinal cord, suggesting a role by Epo within the CNS. Epo and Epo-R is expressed in the mammalian retina, and therefore Epo represents a potential therapy to protect photoreceptors damaged from hypoxic pretreatment.Erythropoietin has been shown to protect nerve cells from hypoxia-induced glutamate toxicity. Acute hypoxia inducement in the adult mouse retina stimulates expression of Epo in addition to other growth factors. Epo response is stimulated by hypoxia and is capable of protecting against apoptosis of erythroid progenitors via a mechanism that is described in the Mechanism of Action section. Epo-R is present in cultured hippocampal and cerebral cortical neurons isolated from rat embryos. Epo was capable of protecting the cultured neurons from glutamate neurotoxicity after only a short exposure. It was concluded that Epo-mediated increase in intracellular calcium concentration is indicative of Epo's neuroprotective role after CNS-related hypoxia or ischemia.Erythropoietin’s role in reducing immune response has been described recently by Michael Brines through his research in administering recombinant human Epo into the blood circulation, which was translocated to the cerebrospinal fluid. RhEpo administer in rats prevented apoptosis of neurons during a cerebral arterial occlusion. It also reduced infarction volume by 75% and decreased post-infarct inflammation.Epo has also been demonstrated to enhance nerve recovery after spinal trauma. Celik and associates investigated motor neuron apoptosis in rabbits with a transient global spinal ischemia model. The functional neurological status of animals given RhEpo was better after recovery from anesthesia, and kept improving over a two-day period. The animals given saline demonstrated a poor functional neurological status and showed no significant improvements. These results showed that RhEpo has both an acute and delayed beneficial action in ischemic spinal cord injury.".
- Erythropoietin_in_neuroprotection wikiPageID "34882197".
- Erythropoietin_in_neuroprotection wikiPageLength "28665".
- Erythropoietin_in_neuroprotection wikiPageOutDegree "54".
- Erythropoietin_in_neuroprotection wikiPageRevisionID "677998758".
- Erythropoietin_in_neuroprotection wikiPageWikiLink 6-OHDA.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Active_transport.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Allodynia.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Anemia.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Arctic_Sun.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Arctic_Sun_medical_device.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Asphyxia.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Astrocyte.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Astrocytes.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Attention_deficit_hyperactivity_disorder.
- Erythropoietin_in_neuroprotection wikiPageWikiLink B-lymphocyte.
- Erythropoietin_in_neuroprotection wikiPageWikiLink B_cell.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Bleeding.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Blood_brain_barrier.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Blood–brain_barrier.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Cardiac_muscle.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Category:Neurology.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Cerebral_palsy.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Dopaminergic.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Dorsal_root_ganglion.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Endocardium.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Endothelial_cells.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Endothelium.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Erythropoiesis.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Erythropoietin.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Excitotoxicity.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Free_radical.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Gacyclidine.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Glaucoma.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Glutamate_toxicity.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Haematopoiesis.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Hematopoietic.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Hemorrhage.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Hippocampus.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Hypothermia_therapy_for_neonatal_encephalopathy.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Hypoxia_(medical).
- Erythropoietin_in_neuroprotection wikiPageWikiLink Inflammation.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Inflammatory_response.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Intellectual_disability.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Ischemia.
- Erythropoietin_in_neuroprotection wikiPageWikiLink JAK2.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Janus_kinase_2.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Liver.
- Erythropoietin_in_neuroprotection wikiPageWikiLink MRNA.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Mental_retardation.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Messenger_RNA.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Methylprednisolone.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Motor_neuron.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Myocardium.
- Erythropoietin_in_neuroprotection wikiPageWikiLink NF-κB.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Neonatal_stroke.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Nervous_system.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Neuroblast.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Neuroblasts.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Neurogenesis.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Neuroprotection.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Neuroregeneration.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Nitrous_oxide.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Oxidopamine.
- Erythropoietin_in_neuroprotection wikiPageWikiLink PI3-K.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Pacini_bodies.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Parkinsons_disease.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Parkinson’s_Disease.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Peripheral_nervous_system.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Phosphoinositide_3-kinase.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Primary_and_secondary_brain_injury.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Radical_(chemistry).
- Erythropoietin_in_neuroprotection wikiPageWikiLink Receptor_(biochemistry).
- Erythropoietin_in_neuroprotection wikiPageWikiLink Retinal_ganglion_cell.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Schwann_cell.
- Erythropoietin_in_neuroprotection wikiPageWikiLink Schwann_cells.
- Erythropoietin_in_neuroprotection wikiPageWikiLink T-lymphocyte.
- Erythropoietin_in_neuroprotection wikiPageWikiLink T_cell.
- Erythropoietin_in_neuroprotection wikiPageWikiLinkText "erythropoietin in neuroprotection".
- Erythropoietin_in_neuroprotection hasPhotoCollection Erythropoietin_in_neuroprotection.
- Erythropoietin_in_neuroprotection wikiPageUsesTemplate Template:Reflist.
- Erythropoietin_in_neuroprotection subject Category:Neurology.
- Erythropoietin_in_neuroprotection hypernym Use.
- Erythropoietin_in_neuroprotection type Specialty.
- Erythropoietin_in_neuroprotection comment "Erythropoietin in neuroprotection is the use of the glycoprotein erythropoietin (Epo) for neuroprotection. Epo controls erythropoiesis, or red blood cell production.Erythropoietin and its receptor are both present in the central nervous system with erythropoietin alpha capable of crossing the blood brain barrier via active transport. The presence of Epo within the spinal fluid of infants and the expression of Epo-R in the spinal cord, suggesting a role by Epo within the CNS.".
- Erythropoietin_in_neuroprotection label "Erythropoietin in neuroprotection".
- Erythropoietin_in_neuroprotection sameAs m.0j43_qb.
- Erythropoietin_in_neuroprotection sameAs Q5396507.
- Erythropoietin_in_neuroprotection sameAs Q5396507.
- Erythropoietin_in_neuroprotection wasDerivedFrom Erythropoietin_in_neuroprotection?oldid=677998758.
- Erythropoietin_in_neuroprotection isPrimaryTopicOf Erythropoietin_in_neuroprotection.