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- Epistasis_and_functional_genomics abstract "Epistasis refers to genetic interactions in which the mutation of one gene masks the phenotypic effects of a mutation at another locus. Systematic analysis of these epistatic interactions can provide insight into the structure and function of genetic pathways. Examining the phenotypes resulting from pairs of mutations helps in understanding how the function of these genes intersects. Genetic interactions are generally classified as either Positive/Alleviating or Negative/Aggravating. Fitness epistasis (an interaction between non-allelic genes) is positive (in other words, diminishing, antagonistic or buffering) when a loss of function mutation of two given genes results in exceeding the fitness predicted from individual effects of deleterious mutations, and it is negative (that is, reinforcing, synergistic or aggravating) when it decreases fitness. Ryszard Korona and Lukas Jasnos showed that the epistatic effect is usually positive in Saccharomyces cerevisiae. Usually, even in case of positive interactions double mutant has smaller fitness than single mutants.The positive interactions occur often when both genes lie within the same pathway Conversely, negative interactions are characterized by an even stronger defect than would be expected in the case of two single mutations, and in the most extreme cases (synthetic sick/lethal) the double mutation is lethal. This aggravated phenotype arises when genes in compensatory pathways are both knocked out.High-throughput methods of analyzing these types of interactions have been useful in expanding our knowledge of genetic interactions. Synthetic genetic arrays (SGA), diploid based synthetic lethality analysis on microarrays (dSLAM), and epistatic miniarray profiles (E-MAP) are three important methods which have been developed for the systematic analysis and mapping of genetic interactions. This systematic approach to studying epistasis on a genome wide scale has significant implications for functional genomics. By identifying the negative and positive interactions between an unknown gene and a set genes within a known pathway, these methods can elucidate the function of previously uncharacterized genes within the context of a metabolic or developmental pathway.".
- Epistasis_and_functional_genomics wikiPageID "25278985".
- Epistasis_and_functional_genomics wikiPageLength "13588".
- Epistasis_and_functional_genomics wikiPageOutDegree "30".
- Epistasis_and_functional_genomics wikiPageRevisionID "665729665".
- Epistasis_and_functional_genomics wikiPageWikiLink Affinity_chromatography.
- Epistasis_and_functional_genomics wikiPageWikiLink Affinity_purification.
- Epistasis_and_functional_genomics wikiPageWikiLink Allele.
- Epistasis_and_functional_genomics wikiPageWikiLink Allelic.
- Epistasis_and_functional_genomics wikiPageWikiLink Antibiotic.
- Epistasis_and_functional_genomics wikiPageWikiLink Antibiotics.
- Epistasis_and_functional_genomics wikiPageWikiLink Binary_classification.
- Epistasis_and_functional_genomics wikiPageWikiLink Caenorhabditis_elegans.
- Epistasis_and_functional_genomics wikiPageWikiLink Category:Genomics.
- Epistasis_and_functional_genomics wikiPageWikiLink Cell_cycle.
- Epistasis_and_functional_genomics wikiPageWikiLink DNA_barcoding.
- Epistasis_and_functional_genomics wikiPageWikiLink Elongation_factor.
- Epistasis_and_functional_genomics wikiPageWikiLink Epistasis.
- Epistasis_and_functional_genomics wikiPageWikiLink Fitness_(biology).
- Epistasis_and_functional_genomics wikiPageWikiLink Functional_genomics.
- Epistasis_and_functional_genomics wikiPageWikiLink Gene_knockout.
- Epistasis_and_functional_genomics wikiPageWikiLink Gene_regulatory_network.
- Epistasis_and_functional_genomics wikiPageWikiLink Genetic_locus.
- Epistasis_and_functional_genomics wikiPageWikiLink Genetic_marker.
- Epistasis_and_functional_genomics wikiPageWikiLink Genetic_pathway.
- Epistasis_and_functional_genomics wikiPageWikiLink Hierarchical_clustering.
- Epistasis_and_functional_genomics wikiPageWikiLink High-throughput_screening.
- Epistasis_and_functional_genomics wikiPageWikiLink Locus_(genetics).
- Epistasis_and_functional_genomics wikiPageWikiLink MRNA.
- Epistasis_and_functional_genomics wikiPageWikiLink Messenger_RNA.
- Epistasis_and_functional_genomics wikiPageWikiLink Metabolic_pathway.
- Epistasis_and_functional_genomics wikiPageWikiLink Model_organism.
- Epistasis_and_functional_genomics wikiPageWikiLink Molecularly_bar-coded.
- Epistasis_and_functional_genomics wikiPageWikiLink Mutation.
- Epistasis_and_functional_genomics wikiPageWikiLink Phenotype.
- Epistasis_and_functional_genomics wikiPageWikiLink Phenotypic.
- Epistasis_and_functional_genomics wikiPageWikiLink Protein-protein_interaction.
- Epistasis_and_functional_genomics wikiPageWikiLink Protein–protein_interaction.
- Epistasis_and_functional_genomics wikiPageWikiLink Saccharomyces_cerevisiae.
- Epistasis_and_functional_genomics wikiPageWikiLink Stop_codon.
- Epistasis_and_functional_genomics wikiPageWikiLink Synthetic_genetic_array.
- Epistasis_and_functional_genomics wikiPageWikiLink Synthetic_genetic_arrays.
- Epistasis_and_functional_genomics wikiPageWikiLink Synthetic_lethality.
- Epistasis_and_functional_genomics wikiPageWikiLink lethal.
- Epistasis_and_functional_genomics wikiPageWikiLink Transcriptional_regulation.
- Epistasis_and_functional_genomics wikiPageWikiLinkText "Epistasis and functional genomics".
- Epistasis_and_functional_genomics wikiPageWikiLinkText "compensatory mutations".
- Epistasis_and_functional_genomics wikiPageWikiLinkText "negative as positive interactions".
- Epistasis_and_functional_genomics hasPhotoCollection Epistasis_and_functional_genomics.
- Epistasis_and_functional_genomics subject Category:Genomics.
- Epistasis_and_functional_genomics type Genomic.
- Epistasis_and_functional_genomics type Omic.
- Epistasis_and_functional_genomics comment "Epistasis refers to genetic interactions in which the mutation of one gene masks the phenotypic effects of a mutation at another locus. Systematic analysis of these epistatic interactions can provide insight into the structure and function of genetic pathways. Examining the phenotypes resulting from pairs of mutations helps in understanding how the function of these genes intersects. Genetic interactions are generally classified as either Positive/Alleviating or Negative/Aggravating.".
- Epistasis_and_functional_genomics label "Epistasis and functional genomics".
- Epistasis_and_functional_genomics sameAs m.09gg82_.
- Epistasis_and_functional_genomics sameAs Q5383574.
- Epistasis_and_functional_genomics sameAs Q5383574.
- Epistasis_and_functional_genomics wasDerivedFrom Epistasis_and_functional_genomics?oldid=665729665.
- Epistasis_and_functional_genomics isPrimaryTopicOf Epistasis_and_functional_genomics.