Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/Epigenetics_of_autism> ?p ?o }
- Epigenetics_of_autism abstract "Autism spectrum disorder (ASD) includes autism, Asperger disorder, childhood disintegrative disorder and pervasive developmental disorder-not otherwise specified. While the exact cause of ASD has remained somewhat of a mystery, it appears to be genetic in origin. Most data supports a polygenic, epistatic model, meaning that the disorder is caused by two or more genes and that those genes are interacting in a complex manner. Several genes, between two to fifteen in number, have been identified and could potentially contribute to disease susceptibility. However, an exact determination of the cause of ASD has yet to be discovered and there probably is not one single genetic cause of any particular set of disorders, leading many researchers to believe that epigenetic mechanisms, such as genomic imprinting or epimutations, may play a major role.Epigenetic mechanisms can contribute to disease phenotypes. Epigenetic modifications include DNA cytosine methylation and post-translational modifications to histones. These mechanisms contribute to regulating gene expression without changing the sequence of the DNA and may be influenced by exposure to environmental factors and may be heritable from parents. Rett syndrome and Fragile X syndrome (FXS) are single gene disorders related to ASD with overlapping symptoms that include deficient neurological development, impaired language and communication, difficulties in social interactions, and stereotyped hand gestures. It is not uncommon for a patient to be diagnosed with both ASD and Rett syndrome and/or FXS. Epigenetic regulatory mechanisms play the central role in pathogenesis of these two diseases. Rett syndrome is caused by a mutation in the gene that encodes methyl-CpG-binding protein (MECP2), one of the key epigenetic regulators of gene expression. MeCP2 binds methylated cytosine residues in DNA and interacts with complexes that remodel chromatin into repressive structures. On the other hand, FXS is caused by mutations that are both genetic and epigenetic. Expansion of the CGG repeat in the 5’-untranslated region of the FMR1 genes leads to susceptibility of epigenetic silencing, leading to loss of gene expression.Genomic imprinting may also contribute to ASD. Genomic imprinting is another example of epigenetic regulation of gene expression. In this instance, the epigenetic modification(s) causes the offspring to express the maternal copy of a gene or the paternal copy of a gene, but not both. The imprinted gene is silenced through epigenetic mechanisms. Candidate genes and susceptibility alleles for autism are identified using a combination of techniques, including genome-wide and targeted analyses of allele sharing in sib-pairs, using association studies and transmission disequilibrium testing (TDT) of functional and/or positional candidate genes and examination of novel and recurrent cytogenetic aberrations. Results from numerous studies have identified several genomic regions known to be subject to imprinting, candidate genes, and gene-environment interactions. Particularly, chromosomes 15q and 7q appear to be epigenetic hotspots in contributing to ASD. Also, genes on the X chromosome may play an important role, as in Rett Syndrome.".
- Epigenetics_of_autism wikiPageID "35773166".
- Epigenetics_of_autism wikiPageLength "31634".
- Epigenetics_of_autism wikiPageOutDegree "117".
- Epigenetics_of_autism wikiPageRevisionID "681943004".
- Epigenetics_of_autism wikiPageWikiLink 15q11-13.
- Epigenetics_of_autism wikiPageWikiLink ACVRL1.
- Epigenetics_of_autism wikiPageWikiLink ATP10A.
- Epigenetics_of_autism wikiPageWikiLink Activin_receptor-like_kinase_I.
- Epigenetics_of_autism wikiPageWikiLink Allele.
- Epigenetics_of_autism wikiPageWikiLink Aminophospholipid_translocase.
- Epigenetics_of_autism wikiPageWikiLink Angelman_syndrome.
- Epigenetics_of_autism wikiPageWikiLink Anti-sense_RNA.
- Epigenetics_of_autism wikiPageWikiLink Antisense_RNA.
- Epigenetics_of_autism wikiPageWikiLink Antisense_strand.
- Epigenetics_of_autism wikiPageWikiLink Asperger_disorder.
- Epigenetics_of_autism wikiPageWikiLink Asperger_syndrome.
- Epigenetics_of_autism wikiPageWikiLink Autism.
- Epigenetics_of_autism wikiPageWikiLink Autism_spectrum.
- Epigenetics_of_autism wikiPageWikiLink Autopsy.
- Epigenetics_of_autism wikiPageWikiLink Bilallelically.
- Epigenetics_of_autism wikiPageWikiLink Bisulfite_sequencing.
- Epigenetics_of_autism wikiPageWikiLink COPG2.
- Epigenetics_of_autism wikiPageWikiLink COPG2IT1.
- Epigenetics_of_autism wikiPageWikiLink CPA4_(gene).
- Epigenetics_of_autism wikiPageWikiLink Calcitonin.
- Epigenetics_of_autism wikiPageWikiLink Calcium_metabolism.
- Epigenetics_of_autism wikiPageWikiLink Category:Autism.
- Epigenetics_of_autism wikiPageWikiLink Category:Epigenetics.
- Epigenetics_of_autism wikiPageWikiLink Centromere.
- Epigenetics_of_autism wikiPageWikiLink Centromeric.
- Epigenetics_of_autism wikiPageWikiLink Cerebral_cortex.
- Epigenetics_of_autism wikiPageWikiLink Childhood_disintegrative_disorder.
- Epigenetics_of_autism wikiPageWikiLink Chromatin_immunoprecipitation.
- Epigenetics_of_autism wikiPageWikiLink Chromosome_15_(human).
- Epigenetics_of_autism wikiPageWikiLink Chromosome_7_(human).
- Epigenetics_of_autism wikiPageWikiLink Chromosome_duplication.
- Epigenetics_of_autism wikiPageWikiLink CpG_island.
- Epigenetics_of_autism wikiPageWikiLink CpG_site.
- Epigenetics_of_autism wikiPageWikiLink DLX2.
- Epigenetics_of_autism wikiPageWikiLink DLX5.
- Epigenetics_of_autism wikiPageWikiLink DLX6.
- Epigenetics_of_autism wikiPageWikiLink DNA_cytosine_methylation.
- Epigenetics_of_autism wikiPageWikiLink DNA_methylation.
- Epigenetics_of_autism wikiPageWikiLink Dendrite.
- Epigenetics_of_autism wikiPageWikiLink Dendritic_spine.
- Epigenetics_of_autism wikiPageWikiLink Disease_phenotype.
- Epigenetics_of_autism wikiPageWikiLink EGR2.
- Epigenetics_of_autism wikiPageWikiLink Epigenetic.
- Epigenetics_of_autism wikiPageWikiLink Epigenetics.
- Epigenetics_of_autism wikiPageWikiLink Epistasis.
- Epigenetics_of_autism wikiPageWikiLink Epistatic.
- Epigenetics_of_autism wikiPageWikiLink FMR1.
- Epigenetics_of_autism wikiPageWikiLink Forebrain.
- Epigenetics_of_autism wikiPageWikiLink Fragile_X_syndrome.
- Epigenetics_of_autism wikiPageWikiLink G-protein_coupled_receptor.
- Epigenetics_of_autism wikiPageWikiLink GABA.
- Epigenetics_of_autism wikiPageWikiLink GABAA_receptor.
- Epigenetics_of_autism wikiPageWikiLink GABAergic.
- Epigenetics_of_autism wikiPageWikiLink GABRA5.
- Epigenetics_of_autism wikiPageWikiLink GABRB3.
- Epigenetics_of_autism wikiPageWikiLink GABRG3.
- Epigenetics_of_autism wikiPageWikiLink G_protein–coupled_receptor.
- Epigenetics_of_autism wikiPageWikiLink Gamma-Aminobutyric_acid.
- Epigenetics_of_autism wikiPageWikiLink Gender_bias.
- Epigenetics_of_autism wikiPageWikiLink Gene_duplication.
- Epigenetics_of_autism wikiPageWikiLink Gene_expression.
- Epigenetics_of_autism wikiPageWikiLink Genomic_imprinting.
- Epigenetics_of_autism wikiPageWikiLink Glutamate_decarboxylase.
- Epigenetics_of_autism wikiPageWikiLink Glutamate_receptor.
- Epigenetics_of_autism wikiPageWikiLink Glutamate_receptors.
- Epigenetics_of_autism wikiPageWikiLink Glutamic_acid_decarboxylase.
- Epigenetics_of_autism wikiPageWikiLink Hippocampus.
- Epigenetics_of_autism wikiPageWikiLink Histone.
- Epigenetics_of_autism wikiPageWikiLink Histone_deacetylase_inhibitor.
- Epigenetics_of_autism wikiPageWikiLink Homologous_pairing.
- Epigenetics_of_autism wikiPageWikiLink Hypothalamus.
- Epigenetics_of_autism wikiPageWikiLink Imprinted_gene.
- Epigenetics_of_autism wikiPageWikiLink Imprinting_control_region.
- Epigenetics_of_autism wikiPageWikiLink Language_disorder.
- Epigenetics_of_autism wikiPageWikiLink MAGEL2.
- Epigenetics_of_autism wikiPageWikiLink MECP2.
- Epigenetics_of_autism wikiPageWikiLink MESTIT1.
- Epigenetics_of_autism wikiPageWikiLink MESTIT1_(gene).
- Epigenetics_of_autism wikiPageWikiLink MEST_(gene).
- Epigenetics_of_autism wikiPageWikiLink MKRN3.
- Epigenetics_of_autism wikiPageWikiLink MeCP2.
- Epigenetics_of_autism wikiPageWikiLink Methyl-CpG-binding_protein.
- Epigenetics_of_autism wikiPageWikiLink Monosomy.
- Epigenetics_of_autism wikiPageWikiLink NDN_(gene).
- Epigenetics_of_autism wikiPageWikiLink Neurabin.
- Epigenetics_of_autism wikiPageWikiLink Neural_development.
- Epigenetics_of_autism wikiPageWikiLink Neurite.
- Epigenetics_of_autism wikiPageWikiLink Neurodevelopment.
- Epigenetics_of_autism wikiPageWikiLink Neuronal_differentiation.
- Epigenetics_of_autism wikiPageWikiLink Neurotransmitter.
- Epigenetics_of_autism wikiPageWikiLink Nucleolar.
- Epigenetics_of_autism wikiPageWikiLink Nucleolus.
- Epigenetics_of_autism wikiPageWikiLink Olfactory_bulb.
- Epigenetics_of_autism wikiPageWikiLink Overexpression.