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- Endomorphin-2 abstract "Endomorphin-2 (EM-2) (amino acid sequence Tyr-Pro-Phe-Phe-NH2) is an endogenous opioid peptide and one of the two endomorphins. It is a high affinity, highly selective agonist of the μ-opioid receptor, and along with endomorphin-1 (EM-1), has been proposed to be the actual endogenous ligand of this receptor (that is, rather than the endorphins). Like EM-1, EM-2 produces analgesia in animals, but whereas EM-1 is more prevalent in the brain, EM-2 is more prevalent in the spinal cord. In addition, the action of EM-2 differs from that of EM-1 somewhat, because EM-2 additionally induces the release of dynorphin A and [Met]enkephalin in the spinal cord and brain by an unknown mechanism, which in turn go on to activate the κ- and δ-opioid receptors, respectively, and a portion of the analgesic effects of EM-2 is dependent on this action. Moreover, while EM-1 produces conditioned place preference, a measure of drug reward, EM-2 produces conditioned place aversion, an effect which is dynorphin A-dependent. Similarly to the case of EM-1, the gene encoding for EM-2 has not yet been identified.".
- Endomorphin-2 iupacName "(L)-Tyrosyl-(L)-prolyl-(L)-phenylalanyl-(L)-phenylalaninamide".
- Endomorphin-2 thumbnail Endomorphin_2.svg?width=300.
- Endomorphin-2 wikiPageID "44927916".
- Endomorphin-2 wikiPageLength "5013".
- Endomorphin-2 wikiPageOutDegree "24".
- Endomorphin-2 wikiPageRevisionID "676915239".
- Endomorphin-2 wikiPageWikiLink Affinity_(pharmacology).
- Endomorphin-2 wikiPageWikiLink Agonist.
- Endomorphin-2 wikiPageWikiLink Amino_acid_sequence.
- Endomorphin-2 wikiPageWikiLink Analgesia.
- Endomorphin-2 wikiPageWikiLink Analgesic.
- Endomorphin-2 wikiPageWikiLink Beta-Endorphin.
- Endomorphin-2 wikiPageWikiLink Brain.
- Endomorphin-2 wikiPageWikiLink Brain_stimulation_reward.
- Endomorphin-2 wikiPageWikiLink Category:Mu-opioid_agonists.
- Endomorphin-2 wikiPageWikiLink Category:Neuropeptides.
- Endomorphin-2 wikiPageWikiLink Conditioned_place_aversion.
- Endomorphin-2 wikiPageWikiLink Conditioned_place_preference.
- Endomorphin-2 wikiPageWikiLink Drug_reward.
- Endomorphin-2 wikiPageWikiLink Dynorphin_A.
- Endomorphin-2 wikiPageWikiLink Endogenous.
- Endomorphin-2 wikiPageWikiLink Endogeny_(biology).
- Endomorphin-2 wikiPageWikiLink Endomorphin.
- Endomorphin-2 wikiPageWikiLink Endorphin.
- Endomorphin-2 wikiPageWikiLink Endorphins.
- Endomorphin-2 wikiPageWikiLink Gene.
- Endomorphin-2 wikiPageWikiLink Ligand_(biochemistry).
- Endomorphin-2 wikiPageWikiLink Mechanism_of_action.
- Endomorphin-2 wikiPageWikiLink Met-enkephalin.
- Endomorphin-2 wikiPageWikiLink Opioid_peptide.
- Endomorphin-2 wikiPageWikiLink Peptide_sequence.
- Endomorphin-2 wikiPageWikiLink Spinal_cord.
- Endomorphin-2 wikiPageWikiLink Β-Endorphin.
- Endomorphin-2 wikiPageWikiLink Δ-opioid_receptor.
- Endomorphin-2 wikiPageWikiLink Κ-opioid_receptor.
- Endomorphin-2 wikiPageWikiLink Μ-opioid_receptor.
- Endomorphin-2 wikiPageWikiLinkText "Endomorphin-2".
- Endomorphin-2 wikiPageWikiLinkText "endomorphin-2".
- Endomorphin-2 hasPhotoCollection Endomorphin-2.
- Endomorphin-2 imagefile "Endomorphin 2.svg".
- Endomorphin-2 imagesize "200".
- Endomorphin-2 iupacname "(L)-Tyrosyl-(L)-prolyl-(L)-phenylalanyl-(L)-phenylalaninamide".
- Endomorphin-2 wikiPageUsesTemplate Template:Biochemistry-stub.
- Endomorphin-2 wikiPageUsesTemplate Template:Chembox.
- Endomorphin-2 wikiPageUsesTemplate Template:Neuropeptides.
- Endomorphin-2 wikiPageUsesTemplate Template:Opioidergics.
- Endomorphin-2 wikiPageUsesTemplate Template:Reflist.
- Endomorphin-2 subject Category:Mu-opioid_agonists.
- Endomorphin-2 subject Category:Neuropeptides.
- Endomorphin-2 hypernym Peptide.
- Endomorphin-2 type ChemicalCompound.
- Endomorphin-2 type ChemicalSubstance.
- Endomorphin-2 type ChemicalObject.
- Endomorphin-2 type Thing.
- Endomorphin-2 type Q11173.
- Endomorphin-2 comment "Endomorphin-2 (EM-2) (amino acid sequence Tyr-Pro-Phe-Phe-NH2) is an endogenous opioid peptide and one of the two endomorphins. It is a high affinity, highly selective agonist of the μ-opioid receptor, and along with endomorphin-1 (EM-1), has been proposed to be the actual endogenous ligand of this receptor (that is, rather than the endorphins). Like EM-1, EM-2 produces analgesia in animals, but whereas EM-1 is more prevalent in the brain, EM-2 is more prevalent in the spinal cord.".
- Endomorphin-2 label "Endomorphin-2".
- Endomorphin-2 sameAs m.012l6kvx.
- Endomorphin-2 sameAs Q19597070.
- Endomorphin-2 sameAs Q19597070.
- Endomorphin-2 wasDerivedFrom Endomorphin-2?oldid=676915239.
- Endomorphin-2 depiction Endomorphin_2.svg.
- Endomorphin-2 isPrimaryTopicOf Endomorphin-2.