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- EVT-201 abstract "EVT-201 is a benzodiazepine derivative drug and partial positive allosteric modulator of the benzodiazepine site of the GABAA receptor. It has 2–4-fold higher functional affinity for the α1 subunit relative to the α2, α3, and α5 subunits and significantly less intrinsic activity in comparison to currently-marketed benzodiazepines and the Z-drugs. Despite the lower efficacy, EVT-201 still shows effectiveness in the treatment of insomnia, and it is thought that the lower efficacy may result in fewer side effects, such as motor incoordination. The drug was originally developed by Roche, based on preclinical data, as a non-sedating anxiolytic, but was found to produce sedation in humans in phase I clinical trials. For this reason, it was subsequently licensed to Evotec, which is now developing it for the treatment of insomnia. As of 2007, EVT-201 has completed phase II clinical trials for this indication, with positive findings reported. No phase III data has yet been reported as of 2014.".
- EVT-201 atcPrefix "None".
- EVT-201 casNumber "308239-86-3".
- EVT-201 iupacName "7-Chloro-3-{5-[(dimethylamino)methyl]-1,2,4-oxadiazol-3-yl}-5-methyl-4,5-dihydro-6H-imidazo[1,5-a][1,4]benzodiazepin-6-one".
- EVT-201 pubchem "9885841".
- EVT-201 thumbnail EVT-201.svg?width=300.
- EVT-201 wikiPageID "44927485".
- EVT-201 wikiPageLength "4766".
- EVT-201 wikiPageOutDegree "35".
- EVT-201 wikiPageRevisionID "673923374".
- EVT-201 wikiPageWikiLink Affinity_(pharmacology).
- EVT-201 wikiPageWikiLink Allosteric_modulator.
- EVT-201 wikiPageWikiLink Anxiolytic.
- EVT-201 wikiPageWikiLink Ataxia.
- EVT-201 wikiPageWikiLink Benzodiazepine.
- EVT-201 wikiPageWikiLink Benzodiazepine_site.
- EVT-201 wikiPageWikiLink Category:Amines.
- EVT-201 wikiPageWikiLink Category:Benzodiazepines.
- EVT-201 wikiPageWikiLink Category:Chloroarenes.
- EVT-201 wikiPageWikiLink Category:GABAA_receptor_positive_allosteric_modulators.
- EVT-201 wikiPageWikiLink Category:Hypnotics.
- EVT-201 wikiPageWikiLink Category:Imidazoles.
- EVT-201 wikiPageWikiLink Category:Ketones.
- EVT-201 wikiPageWikiLink Category:Oxadiazoles.
- EVT-201 wikiPageWikiLink Category:Sedatives.
- EVT-201 wikiPageWikiLink Chemical_derivative.
- EVT-201 wikiPageWikiLink Clinical_trial.
- EVT-201 wikiPageWikiLink Derivative_(chemistry).
- EVT-201 wikiPageWikiLink Drug.
- EVT-201 wikiPageWikiLink Evotec.
- EVT-201 wikiPageWikiLink GABAA_receptor.
- EVT-201 wikiPageWikiLink GABRA1.
- EVT-201 wikiPageWikiLink GABRA2.
- EVT-201 wikiPageWikiLink GABRA3.
- EVT-201 wikiPageWikiLink GABRA5.
- EVT-201 wikiPageWikiLink Gamma-aminobutyric_acid_receptor_subunit_alpha-1.
- EVT-201 wikiPageWikiLink Hoffmann-La_Roche.
- EVT-201 wikiPageWikiLink Insomnia.
- EVT-201 wikiPageWikiLink Intrinsic_activity.
- EVT-201 wikiPageWikiLink Ligand_(biochemistry).
- EVT-201 wikiPageWikiLink Motor_incoordination.
- EVT-201 wikiPageWikiLink Partial_agonist.
- EVT-201 wikiPageWikiLink Phase_III.
- EVT-201 wikiPageWikiLink Phases_of_clinical_research.
- EVT-201 wikiPageWikiLink Positive_allosteric_modulator.
- EVT-201 wikiPageWikiLink Pre-clinical_development.
- EVT-201 wikiPageWikiLink Preclinical.
- EVT-201 wikiPageWikiLink Sedation.
- EVT-201 wikiPageWikiLink Side_effect.
- EVT-201 wikiPageWikiLink Z-drug.
- EVT-201 wikiPageWikiLinkText "EVT-201".
- EVT-201 atcPrefix "None".
- EVT-201 casNumber "308239".
- EVT-201 chemicalFormula "C17H17ClN6O2".
- EVT-201 chemspiderid "8061514".
- EVT-201 hasPhotoCollection EVT-201.
- EVT-201 inchi "1".
- EVT-201 inchikey "JCYLWUVDHLVGER-UHFFFAOYAJ".
- EVT-201 iupacName "7".
- EVT-201 molecularWeight "372.809".
- EVT-201 pubchem "9885841".
- EVT-201 smiles "Clc4cccc3n2cncc2CNC".
- EVT-201 stdinchi "1".
- EVT-201 stdinchikey "JCYLWUVDHLVGER-UHFFFAOYSA-N".
- EVT-201 wikiPageUsesTemplate Template:Benzodiazepines.
- EVT-201 wikiPageUsesTemplate Template:Drugbox.
- EVT-201 wikiPageUsesTemplate Template:GABAAR_PAMs.
- EVT-201 wikiPageUsesTemplate Template:Insomnia_pharmacotherapies.
- EVT-201 wikiPageUsesTemplate Template:Nervous-system-drug-stub.
- EVT-201 wikiPageUsesTemplate Template:Reflist.
- EVT-201 subject Category:Amines.
- EVT-201 subject Category:Benzodiazepines.
- EVT-201 subject Category:Chloroarenes.
- EVT-201 subject Category:GABAA_receptor_positive_allosteric_modulators.
- EVT-201 subject Category:Hypnotics.
- EVT-201 subject Category:Imidazoles.
- EVT-201 subject Category:Ketones.
- EVT-201 subject Category:Oxadiazoles.
- EVT-201 subject Category:Sedatives.
- EVT-201 hypernym Drug.
- EVT-201 type ChemicalSubstance.
- EVT-201 type Drug.
- EVT-201 type ChemicalObject.
- EVT-201 type Thing.
- EVT-201 type Q8386.
- EVT-201 comment "EVT-201 is a benzodiazepine derivative drug and partial positive allosteric modulator of the benzodiazepine site of the GABAA receptor. It has 2–4-fold higher functional affinity for the α1 subunit relative to the α2, α3, and α5 subunits and significantly less intrinsic activity in comparison to currently-marketed benzodiazepines and the Z-drugs.".
- EVT-201 label "EVT-201".
- EVT-201 sameAs m.012l6dt8.
- EVT-201 sameAs Q19597232.
- EVT-201 sameAs Q19597232.
- EVT-201 wasDerivedFrom EVT-201?oldid=673923374.
- EVT-201 depiction EVT-201.svg.
- EVT-201 isPrimaryTopicOf EVT-201.