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- ERCC1 abstract "DNA excision repair protein ERCC-1 is a protein that in humans is encoded by the ERCC1 gene. Together with ERCC4, ERCC1 forms the ERCC1-XPF enzyme complex that participates in DNA repair and DNA recombination.Many aspects of these two gene products are described together here because they are partners during DNA repair. The ERCC1-XPF nuclease is an essential activity in the pathway of DNA nucleotide excision repair (NER). The ERCC1-XPF nuclease also functions in pathways to repair double-strand breaks in DNA, and in the repair of “crosslink” damage that harmfully links the two DNA strands.Cells with disabling mutations in ERCC1 are more sensitive than normal to particular DNA damaging agents, including ultraviolet (UV) radiation and to chemicals that cause crosslinking between DNA strands. Genetically engineered mice with disabling mutations in ERCC1 have defects in DNA repair, accompanied by metabolic stress-induced changes in physiology that result in premature aging. Complete deletion of ERCC1 is incompatible with viability of mice, and no human individuals have been found with complete (homozygous) deletion of ERCC1. Rare individuals in the human population harbor inherited mutations that impair the function of ERCC1. When the normal genes are absent, these mutations can lead to human syndromes, including Cockayne syndrome (CS) and COFS.ERCC1 and ERCC4 are the gene names assigned in mammalian genomes, including the human genome (Homo sapiens). Similar genes with similar functions are found in all eukaryotic organisms.".
- ERCC1 entrezgene "2067".
- ERCC1 thumbnail Fig_1_ERCC1_Wikigene.png?width=300.
- ERCC1 wikiPageExternalLink br.fcgi?book=gene&part=xp.
- ERCC1 wikiPageID "14149018".
- ERCC1 wikiPageLength "40200".
- ERCC1 wikiPageOutDegree "53".
- ERCC1 wikiPageRevisionID "682843105".
- ERCC1 wikiPageWikiLink Adenocarcinoma.
- ERCC1 wikiPageWikiLink Alternative_splicing.
- ERCC1 wikiPageWikiLink C-terminal.
- ERCC1 wikiPageWikiLink C-terminus.
- ERCC1 wikiPageWikiLink COFS.
- ERCC1 wikiPageWikiLink Cadmium.
- ERCC1 wikiPageWikiLink Carcinogen.
- ERCC1 wikiPageWikiLink Carcinogenesis.
- ERCC1 wikiPageWikiLink Cerebro-oculo-facio-skeletal_syndrome.
- ERCC1 wikiPageWikiLink Chinese_hamster_ovary_cell.
- ERCC1 wikiPageWikiLink Cockayne_syndrome.
- ERCC1 wikiPageWikiLink CofS.
- ERCC1 wikiPageWikiLink Colorectal_cancer.
- ERCC1 wikiPageWikiLink Complementation_(genetics).
- ERCC1 wikiPageWikiLink DNA_recombination.
- ERCC1 wikiPageWikiLink DNA_repair.
- ERCC1 wikiPageWikiLink DNA_repair-deficiency_disorder.
- ERCC1 wikiPageWikiLink Double-strand_breaks.
- ERCC1 wikiPageWikiLink EME1.
- ERCC1 wikiPageWikiLink ERCC4.
- ERCC1 wikiPageWikiLink Epigenetics.
- ERCC1 wikiPageWikiLink Field_cancerization.
- ERCC1 wikiPageWikiLink Gene.
- ERCC1 wikiPageWikiLink Genetic_complementation.
- ERCC1 wikiPageWikiLink HIV.
- ERCC1 wikiPageWikiLink HMGA2.
- ERCC1 wikiPageWikiLink Let-7_microRNA_precursor.
- ERCC1 wikiPageWikiLink MSH2.
- ERCC1 wikiPageWikiLink MUS81.
- ERCC1 wikiPageWikiLink Messenger_RNA.
- ERCC1 wikiPageWikiLink MicroRNA.
- ERCC1 wikiPageWikiLink N-terminal.
- ERCC1 wikiPageWikiLink N-terminus.
- ERCC1 wikiPageWikiLink Non-small-cell_lung_carcinoma.
- ERCC1 wikiPageWikiLink Non-small_cell_lung_carcinoma.
- ERCC1 wikiPageWikiLink Nucleotide_excision_repair.
- ERCC1 wikiPageWikiLink O-6-methylguanine-DNA_methyltransferase.
- ERCC1 wikiPageWikiLink Oxoguanine_glycosylase.
- ERCC1 wikiPageWikiLink P-bodies.
- ERCC1 wikiPageWikiLink Promoter_(genetics).
- ERCC1 wikiPageWikiLink Protein.
- ERCC1 wikiPageWikiLink Protein_expression_(biotechnology).
- ERCC1 wikiPageWikiLink Protein_production_(biotechnology).
- ERCC1 wikiPageWikiLink Protein_turnover.
- ERCC1 wikiPageWikiLink Recombinant_DNA.
- ERCC1 wikiPageWikiLink Saccharomyces_cerevisiae.
- ERCC1 wikiPageWikiLink Schizosaccharomyces_pombe.
- ERCC1 wikiPageWikiLink Trans-activation_response_element_(TAR).
- ERCC1 wikiPageWikiLink Transcription_(genetics).
- ERCC1 wikiPageWikiLink XRCC1.
- ERCC1 wikiPageWikiLink File:Fig_1_ERCC1_Wikigene.png.
- ERCC1 wikiPageWikiLink File:Fig_2_XPF_Substrate_Wikigene.png.
- ERCC1 wikiPageWikiLinkText "ERCC1".
- ERCC1 hasPhotoCollection ERCC1.
- ERCC1 wikiPageUsesTemplate Template:Cite_journal.
- ERCC1 wikiPageUsesTemplate Template:DNA_repair.
- ERCC1 wikiPageUsesTemplate Template:PBB.
- ERCC1 wikiPageUsesTemplate Template:PDB_Gallery.
- ERCC1 wikiPageUsesTemplate Template:Refbegin.
- ERCC1 wikiPageUsesTemplate Template:Refend.
- ERCC1 wikiPageUsesTemplate Template:Reflist.
- ERCC1 hypernym Protein.
- ERCC1 type Article.
- ERCC1 type Biomolecule.
- ERCC1 type Protein.
- ERCC1 type Article.
- ERCC1 type Thing.
- ERCC1 type Q206229.
- ERCC1 type Q8054.
- ERCC1 comment "DNA excision repair protein ERCC-1 is a protein that in humans is encoded by the ERCC1 gene. Together with ERCC4, ERCC1 forms the ERCC1-XPF enzyme complex that participates in DNA repair and DNA recombination.Many aspects of these two gene products are described together here because they are partners during DNA repair. The ERCC1-XPF nuclease is an essential activity in the pathway of DNA nucleotide excision repair (NER).".
- ERCC1 label "ERCC1".
- ERCC1 sameAs ERCC1.
- ERCC1 sameAs ERCC1.
- ERCC1 sameAs m.03cw3st.
- ERCC1 sameAs Q4889741.
- ERCC1 sameAs Q4889741.
- ERCC1 wasDerivedFrom ERCC1?oldid=682843105.
- ERCC1 depiction Fig_1_ERCC1_Wikigene.png.
- ERCC1 isPrimaryTopicOf ERCC1.