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- EPPTB abstract "EPPTB (RO-5212773) is a drug developed by Hoffmann-La Roche which acts as a potent and selective antagonist for the trace amine-associated receptor 1, with no significant activity at other targets. EPPTB is one of the first selective antagonists developed for TAAR1, and has been used to demonstrate an important role for TAAR1 in regulation of dopaminergic signalling in the limbic system. Unfortunately while EPPTB has high affinity for the mouse TAAR1, it has much lower affinity for rat and human TAAR1, which limits its use in research. While the human and mouse forms of TAAR1 have similar functions and bind similar ligands, the actual binding affinities of individual ligands often vary significantly between the two versions of the receptor.".
- EPPTB iupacName "N-(3-ethoxyphenyl)-4-pyrrolidin-1-yl-3-trifluoromethylbenzamide".
- EPPTB pubchem "25175634".
- EPPTB thumbnail EPPTB2DCSD.svg?width=300.
- EPPTB wikiPageID "35643760".
- EPPTB wikiPageLength "2978".
- EPPTB wikiPageOutDegree "7".
- EPPTB wikiPageRevisionID "671768911".
- EPPTB wikiPageWikiLink Antagonist_(pharmacology).
- EPPTB wikiPageWikiLink Category:Receptor_antagonists.
- EPPTB wikiPageWikiLink Dopamine.
- EPPTB wikiPageWikiLink Hoffmann-La_Roche.
- EPPTB wikiPageWikiLink Limbic_system.
- EPPTB wikiPageWikiLink RO5166017.
- EPPTB wikiPageWikiLink Receptor_antagonist.
- EPPTB wikiPageWikiLink TAAR1.
- EPPTB wikiPageWikiLinkText "EPPTB".
- EPPTB c "20".
- EPPTB chemspiderid "26387935".
- EPPTB f "3".
- EPPTB h "21".
- EPPTB hasPhotoCollection EPPTB.
- EPPTB iupacName "N--4-pyrrolidin-1-yl-3-trifluoromethylbenzamide".
- EPPTB molecularWeight "378.387".
- EPPTB n "2".
- EPPTB o "2".
- EPPTB pubchem "25175634".
- EPPTB smiles "CCOc1ccccNCc2cccN3CCCC3".
- EPPTB smiles "CCOc2ccNCcccc1N3CCCC3".
- EPPTB stdinchi "1".
- EPPTB stdinchikey "KLFVWQCQUXXLOU-UHFFFAOYSA-N".
- EPPTB width "200".
- EPPTB wikiPageUsesTemplate Template:Drugbox.
- EPPTB wikiPageUsesTemplate Template:Nervous-system-drug-stub.
- EPPTB wikiPageUsesTemplate Template:TAAR_ligands.
- EPPTB subject Category:Receptor_antagonists.
- EPPTB hypernym Drug.
- EPPTB type Article.
- EPPTB type ChemicalSubstance.
- EPPTB type Drug.
- EPPTB type Article.
- EPPTB type Chemical.
- EPPTB type Science.
- EPPTB type ChemicalObject.
- EPPTB type Thing.
- EPPTB type Q8386.
- EPPTB comment "EPPTB (RO-5212773) is a drug developed by Hoffmann-La Roche which acts as a potent and selective antagonist for the trace amine-associated receptor 1, with no significant activity at other targets. EPPTB is one of the first selective antagonists developed for TAAR1, and has been used to demonstrate an important role for TAAR1 in regulation of dopaminergic signalling in the limbic system.".
- EPPTB label "EPPTB".
- EPPTB sameAs m.0jl07w9.
- EPPTB sameAs EPPTB.
- EPPTB sameAs EPPTB.
- EPPTB sameAs Q5323904.
- EPPTB sameAs Q5323904.
- EPPTB wasDerivedFrom EPPTB?oldid=671768911.
- EPPTB depiction EPPTB2DCSD.svg.
- EPPTB isPrimaryTopicOf EPPTB.