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- DsbA abstract "DsbA is a bacterial disulfide oxidoreductase. DsbA is a key component of the Dsb (disulfide bond) family of enzymes. DsbA forms intrachain disulfide bonds as peptides emerge into the cell's periplasm.Structurally, DsbA contains a thioredoxin domain with an inserted helical domain of unknown function. Like other thioredoxin-based enzymes, DsbA's catalytic site is a CXXC motif (CPHC in E. coli DsbA). The pair of cysteines may be oxidized (forming an internal disulfide) or reduced (as free thiols), and thus allows for oxidoreductase activity by serving as an electron pair donor or acceptor, depending on oxidation state. This reaction generally proceeds through a mixed-disulfide intermediate, in which a cysteine from the enzyme forms a bond to a cysteine on the substrate. DsbA is responsible for introducing disulfide bonds into nascent proteins. In equivalent terms, it catalyzes the oxidation of a pair of cysteine residues on the substrate protein. Most of the substrates for DsbA are eventually secreted, and include important toxins, virulence factors, adhesion machinery, and motility structures DsbA is localized in the periplasm, and is more common in Gram-negative bacteria than in Gram-positive bacteria. Within the thioredoxin family, DsbA is the most strongly oxidizing. Using glutathione oxidation as a metric, DsbA is ten times more oxidizing than protein disulfide-isomerase (the eukaryotic equivalent of DsbA). The extremely oxidizing nature of DsbA is due to an increase in stability upon reduction of DsbA, thereby imparting a decrease in energy of the enzyme when it oxidizes substrate. This feature is incredibly rare among proteins, as nearly all proteins are stabilized by the formation of disulfide bonds. DsbA's highly oxidizing nature is a result of hydrogen bond, electrostatic and helix-dipole interactions that favour the thiolate over the disulfide at the active site.After donating its disulfide bond, DsbA is regenerated by the membrane-bound protein DsbB.".
- DsbA entrezgene "948353".
- DsbA pdb "1A2M".
- DsbA symbol "DSBA".
- DsbA symbol "DsbA".
- DsbA thumbnail Ecoli_DsbA_1A2M.png?width=300.
- DsbA uniprot "P0AEG4".
- DsbA wikiPageID "29200295".
- DsbA wikiPageLength "4503".
- DsbA wikiPageOutDegree "11".
- DsbA wikiPageRevisionID "617241047".
- DsbA wikiPageWikiLink Category:Enzymes.
- DsbA wikiPageWikiLink Cysteine.
- DsbA wikiPageWikiLink Disulfide.
- DsbA wikiPageWikiLink Disulfide_bonds.
- DsbA wikiPageWikiLink Domain_of_unknown_function.
- DsbA wikiPageWikiLink E._coli.
- DsbA wikiPageWikiLink Escherichia_coli.
- DsbA wikiPageWikiLink Gram-negative_bacteria.
- DsbA wikiPageWikiLink Gram-positive_bacteria.
- DsbA wikiPageWikiLink Periplasm.
- DsbA wikiPageWikiLink Protein_disulfide-isomerase.
- DsbA wikiPageWikiLink Thioredoxin_domain.
- DsbA wikiPageWikiLinkText "DsbA".
- DsbA caption "Crystal structure of E. coli DsbA.".
- DsbA entrezgene "948353".
- DsbA hasPhotoCollection DsbA.
- DsbA interpro "IPR001853".
- DsbA name "DSBA oxidoreductase".
- DsbA name "DsbA".
- DsbA pdb "1".
- DsbA pfam "PF01323".
- DsbA symbol "DSBA".
- DsbA symbol "DsbA".
- DsbA uniprot "P0AEG4".
- DsbA wikiPageUsesTemplate Template:Infobox_protein.
- DsbA wikiPageUsesTemplate Template:InterPro_content.
- DsbA wikiPageUsesTemplate Template:Pfam_box.
- DsbA wikiPageUsesTemplate Template:Reflist.
- DsbA subject Category:Enzymes.
- DsbA hypernym Oxidoreductase.
- DsbA type Article.
- DsbA type Biomolecule.
- DsbA type Protein.
- DsbA type Article.
- DsbA type Chemical.
- DsbA type Thing.
- DsbA type Q206229.
- DsbA type Q8054.
- DsbA comment "DsbA is a bacterial disulfide oxidoreductase. DsbA is a key component of the Dsb (disulfide bond) family of enzymes. DsbA forms intrachain disulfide bonds as peptides emerge into the cell's periplasm.Structurally, DsbA contains a thioredoxin domain with an inserted helical domain of unknown function. Like other thioredoxin-based enzymes, DsbA's catalytic site is a CXXC motif (CPHC in E. coli DsbA).".
- DsbA label "DsbA".
- DsbA sameAs m.0dln3y2.
- DsbA sameAs Q5309954.
- DsbA sameAs Q5309954.
- DsbA wasDerivedFrom DsbA?oldid=617241047.
- DsbA depiction Ecoli_DsbA_1A2M.png.
- DsbA isPrimaryTopicOf DsbA.
- DsbA name "DsbA".