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- Drosophila_roX_RNA abstract "RoX RNA is a non-coding RNA (ncRNA) present in the male-specific lethal (MSL) complex and is required for sex dosage compensation in Drosophila. As males only contain one X chromosome, male flies dosage compensate for the X chromosome by hyper-transcribing the X chromosome. This is achieved by the MSL complex binding to the X chromosome and inducing histone H4 lysine 16 acetylation and allows for the formation of euchromatin. These ncRNAs were first discovered in RNA extracted from neuronal cells.Two roX RNAs have been identified in the MSL complex from Drosophila melanogaster and have been shown to be conserved across different drosophila species. The two roX RNAs, known as roX1 and roX2 have been shown to differ in primary sequence and sequence length but despite these differences they both contain a MSL binding site are functionally redundant. Cloning roX genes and subsequent sequence alignment from a number of different drosophila species identified several conserved regions and it was also noticed that roX RNA is only present in male flies.Secondary structure predictions predicted a stem loop to be present at the 3' end of the roX RNA transcripts. Mutagenesis within this region that either altered the sequence or prevented stem loop formation was shown to be lethal in male flies as they were unable to dosage compensate as these mutations prevented MSL binding to the X chromosome. It was also shown that in the presence of mutant roX RNA the MSL complex was unable to localize on the X chromosome and mislocalize to the heterochromatic chromocenter. This suggests that roX RNA plays a role in directing MSL complex to the X chromosome. Sequence alignment of roX2 identified several regions of sequence conservation known as Gub regions and are absent in roX1. Many of these Gub regions are thought to be redundant as mutating has no effect however, Gub1 which is present within the 3' stem loop region is thought to be a key motif required for roX2 as Gub1 mutations were shown to be lethal. These studies show that roX RNA are essential for dosage compensation where that the 3' stem loop region in the roX RNA are crucial for MSL localization and it is thought to be the motif that allows the two roX RNAs to be functionally redundant.".
- Drosophila_roX_RNA thumbnail Rox1_SS.png?width=300.
- Drosophila_roX_RNA wikiPageID "24116619".
- Drosophila_roX_RNA wikiPageLength "6154".
- Drosophila_roX_RNA wikiPageOutDegree "23".
- Drosophila_roX_RNA wikiPageRevisionID "678211429".
- Drosophila_roX_RNA wikiPageWikiLink 3.
- Drosophila_roX_RNA wikiPageWikiLink Acetylation.
- Drosophila_roX_RNA wikiPageWikiLink Biomolecular_structure.
- Drosophila_roX_RNA wikiPageWikiLink Category:Non-coding_RNA.
- Drosophila_roX_RNA wikiPageWikiLink Cloning.
- Drosophila_roX_RNA wikiPageWikiLink Conservation_(genetics).
- Drosophila_roX_RNA wikiPageWikiLink Conserved_sequence.
- Drosophila_roX_RNA wikiPageWikiLink Directionality_(molecular_biology).
- Drosophila_roX_RNA wikiPageWikiLink Dosage_compensation.
- Drosophila_roX_RNA wikiPageWikiLink Drosophila.
- Drosophila_roX_RNA wikiPageWikiLink Drosophila_melanogaster.
- Drosophila_roX_RNA wikiPageWikiLink Euchromatin.
- Drosophila_roX_RNA wikiPageWikiLink Histone.
- Drosophila_roX_RNA wikiPageWikiLink Mutagenesis.
- Drosophila_roX_RNA wikiPageWikiLink Mutant.
- Drosophila_roX_RNA wikiPageWikiLink Non-coding_RNA.
- Drosophila_roX_RNA wikiPageWikiLink Secondary_structure.
- Drosophila_roX_RNA wikiPageWikiLink Sequence_alignment.
- Drosophila_roX_RNA wikiPageWikiLink Sequence_conservation.
- Drosophila_roX_RNA wikiPageWikiLink Stem-loop.
- Drosophila_roX_RNA wikiPageWikiLink Stem_loop.
- Drosophila_roX_RNA wikiPageWikiLink XIST_(gene).
- Drosophila_roX_RNA wikiPageWikiLink X_chromosome.
- Drosophila_roX_RNA wikiPageWikiLink Xist.
- Drosophila_roX_RNA wikiPageWikiLinkText "roX".
- Drosophila_roX_RNA caption "Conserved secondary structure of roX1 RNA".
- Drosophila_roX_RNA hasPhotoCollection Drosophila_roX_RNA.
- Drosophila_roX_RNA id "RF01666".
- Drosophila_roX_RNA id "RF01667".
- Drosophila_roX_RNA name "Drosophila roX1 ncRNA".
- Drosophila_roX_RNA name "Drosophila rox1 ncRNA".
- Drosophila_roX_RNA name "Drosophila rox2 ncRNA".
- Drosophila_roX_RNA rfam "RF01667".
- Drosophila_roX_RNA rnaType "Cis-regulatory element".
- Drosophila_roX_RNA symbol "roX1".
- Drosophila_roX_RNA taxDomain "Drosophila".
- Drosophila_roX_RNA wikiPageUsesTemplate Template:Infobox_rfam.
- Drosophila_roX_RNA wikiPageUsesTemplate Template:Reflist.
- Drosophila_roX_RNA wikiPageUsesTemplate Template:Rfam.
- Drosophila_roX_RNA subject Category:Non-coding_RNA.
- Drosophila_roX_RNA hypernym RNA.
- Drosophila_roX_RNA type Article.
- Drosophila_roX_RNA type Protein.
- Drosophila_roX_RNA type Article.
- Drosophila_roX_RNA comment "RoX RNA is a non-coding RNA (ncRNA) present in the male-specific lethal (MSL) complex and is required for sex dosage compensation in Drosophila. As males only contain one X chromosome, male flies dosage compensate for the X chromosome by hyper-transcribing the X chromosome. This is achieved by the MSL complex binding to the X chromosome and inducing histone H4 lysine 16 acetylation and allows for the formation of euchromatin.".
- Drosophila_roX_RNA label "Drosophila roX RNA".
- Drosophila_roX_RNA sameAs m.07k9vcr.
- Drosophila_roX_RNA sameAs Q5308595.
- Drosophila_roX_RNA sameAs Q5308595.
- Drosophila_roX_RNA wasDerivedFrom Drosophila_roX_RNA?oldid=678211429.
- Drosophila_roX_RNA depiction Rox1_SS.png.
- Drosophila_roX_RNA isPrimaryTopicOf Drosophila_roX_RNA.