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- Dose_fractionation abstract "Experiments in radiation biology have found that as the absorbed dose of radiation increases, the number of cells which survive decreases. They have also found that if the radiation is fractionated into smaller doses, with one or more rest periods in between, fewer cells die. This is because of self-repair mechanisms which repair the damage to DNA and other biomolecules such as proteins. These mechanisms can be over expressed in cancer cells, so caution should be used in using results for a cancer cell line to make predictions for healthy cells if the cancer cell line is known to be resistant to cytotoxic drugs such as cisplatin. The DNA self repair processes in some organisms is exceptionally good; for instance, the bacterium Deinococcus radiodurans can tolerate a 15 000 Gy (1.5 MRad) dose.In the graph below, called a cell survival curve, the dose vs. surviving fraction have been drawn for a hypothetical group of cells with and without a rest time for the cells to recover. Other than the recovery time partway through the irradiation, the cells would have been treated identically.The human body contains many types of cells, and the human can be killed by the loss of a single type of cells in a vital organ. For many short-term radiation deaths due to what is commonly known as radiation sickness (3 days to 30 days after exposure), it is the loss of bone marrow cells (which produce blood cells), and the loss of other cells in the wall of the intestines, that is fatal.".
- Dose_fractionation thumbnail Effectofselfrepair_2.png?width=300.
- Dose_fractionation wikiPageID "7049417".
- Dose_fractionation wikiPageLength "3561".
- Dose_fractionation wikiPageOutDegree "32".
- Dose_fractionation wikiPageRevisionID "642022984".
- Dose_fractionation wikiPageWikiLink Absorbed_dose.
- Dose_fractionation wikiPageWikiLink Acute_radiation_syndrome.
- Dose_fractionation wikiPageWikiLink Blood_cell.
- Dose_fractionation wikiPageWikiLink Blood_cells.
- Dose_fractionation wikiPageWikiLink Bone_marrow.
- Dose_fractionation wikiPageWikiLink Cancer.
- Dose_fractionation wikiPageWikiLink Category:Cell_biology.
- Dose_fractionation wikiPageWikiLink Category:DNA.
- Dose_fractionation wikiPageWikiLink Category:Radiation.
- Dose_fractionation wikiPageWikiLink Cell_(biology).
- Dose_fractionation wikiPageWikiLink Cell_death.
- Dose_fractionation wikiPageWikiLink Cell_survival_curve.
- Dose_fractionation wikiPageWikiLink Cisplatin.
- Dose_fractionation wikiPageWikiLink Cytotoxicity.
- Dose_fractionation wikiPageWikiLink DNA.
- Dose_fractionation wikiPageWikiLink DNA_repair.
- Dose_fractionation wikiPageWikiLink Deinococcus_radiodurans.
- Dose_fractionation wikiPageWikiLink Experiment.
- Dose_fractionation wikiPageWikiLink Gray_(unit).
- Dose_fractionation wikiPageWikiLink Human_body.
- Dose_fractionation wikiPageWikiLink Human_gastrointestinal_tract.
- Dose_fractionation wikiPageWikiLink Hypothesis.
- Dose_fractionation wikiPageWikiLink Hypothetical.
- Dose_fractionation wikiPageWikiLink Intestines.
- Dose_fractionation wikiPageWikiLink Organ_(anatomy).
- Dose_fractionation wikiPageWikiLink Protein.
- Dose_fractionation wikiPageWikiLink Proteins.
- Dose_fractionation wikiPageWikiLink Radiation.
- Dose_fractionation wikiPageWikiLink Radiation_biology.
- Dose_fractionation wikiPageWikiLink Radiation_sickness.
- Dose_fractionation wikiPageWikiLink Radiation_therapy.
- Dose_fractionation wikiPageWikiLink Radiobiology.
- Dose_fractionation wikiPageWikiLink Side_effect.
- Dose_fractionation wikiPageWikiLink Side_effects.
- Dose_fractionation wikiPageWikiLink Toxic.
- Dose_fractionation wikiPageWikiLink Toxicity.
- Dose_fractionation wikiPageWikiLink File:Effectofselfrepair_2.png.
- Dose_fractionation wikiPageWikiLinkText "Dose fractionation".
- Dose_fractionation wikiPageWikiLinkText "dose fractionation".
- Dose_fractionation wikiPageWikiLinkText "dose was fractionated".
- Dose_fractionation wikiPageWikiLinkText "fractionated".
- Dose_fractionation hasPhotoCollection Dose_fractionation.
- Dose_fractionation wikiPageUsesTemplate Template:Portal_bar.
- Dose_fractionation wikiPageUsesTemplate Template:Radiation_poisoning.
- Dose_fractionation wikiPageUsesTemplate Template:Reflist.
- Dose_fractionation subject Category:Cell_biology.
- Dose_fractionation subject Category:DNA.
- Dose_fractionation subject Category:Radiation.
- Dose_fractionation comment "Experiments in radiation biology have found that as the absorbed dose of radiation increases, the number of cells which survive decreases. They have also found that if the radiation is fractionated into smaller doses, with one or more rest periods in between, fewer cells die. This is because of self-repair mechanisms which repair the damage to DNA and other biomolecules such as proteins.".
- Dose_fractionation label "Dose fractionation".
- Dose_fractionation sameAs m.0h1zm7.
- Dose_fractionation sameAs Q5299253.
- Dose_fractionation sameAs Q5299253.
- Dose_fractionation wasDerivedFrom Dose_fractionation?oldid=642022984.
- Dose_fractionation depiction Effectofselfrepair_2.png.
- Dose_fractionation isPrimaryTopicOf Dose_fractionation.