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- Dirty_drug abstract "In pharmacology, a dirty drug is an informal term for drugs that may bind to many different molecular targets or receptors in the body, and so tend to have a wide range of effects and possibly adverse drug reactions. Today, pharmaceutical companies try to make new drugs as selective as possible to minimise binding to antitargets and hence reduce the occurrence of side effects and risk of adverse reactions.Examples of compounds often cited as "dirty drugs" include chlorpromazine, dextromethorphan and ibogaine, all of which bind to multiple receptors or influence multiple receptor systems. There may be instances of advantages to drugs that exhibit multi-receptor activity such as the anti-addictive drug ibogaine that acts within a broad range of neurohormonal systems where activity is also exhibited by drugs commonly associated with addiction including opioids, nicotine, and alcohol. Similarly chlorpromazine is primarily used as an antipsychotic, but its strong serotonin receptor blocking effects make it useful for treating serotonergic crisis such as serotonin syndrome. Dextromethorphan for its part is widely used as a cough medication, but its other actions have led to trials for several conditions such as its use as an adjunct to analgesia, and a potential anti-addictive drug, as well as its occasional recreational use as a dissociative.Kanamycin is an aminoglycoside antibiotic which induces deafness through blockage of the Outer Hair Cells of the cochlea; yet it has many other effects, weakening for instance the collagen and DNA biosynthesis. It acts by inhibiting the synthesis of proteins in susceptible organisms. Kanamycin requires close clinical supervision because of its potential toxicity and adverse side effects to the auditory and vestibular branches of the eighth cranial nerve and to the renal tubules.Clozapine and dimebon are examples of drugs used in the treatment of CNS disorders that have a superior efficacy precisely because of their "multifarious" broadspectrum mode of activity. Likewise, in cancer chemotherapeutics, it has been recognized that drugs active at more than one target have a higher probability of being efficacious.Examples of "promiscuous" cancer drugs include: Sutent, Sorafenib, Zactima, and AG-013736.In the field of drugs used to treat depression, the nonselective MAOIs and the TCAs are sometimes believed to have an efficacy that is superior to the SSRIs. Why then are the SSRIs normally picked as the first-line choice of agent and not the (less-selective) MAOIs and TCAs? There are several answers. TCAs are very dangerous in overdose compared to SSRIs. TCA overdose often results in death, which is a serious problem because depressed patients may be at risk of suicide attempts. MAOIs can cause serious side effects when mixed with certain foods, including life-threatening hypertensive crisis. MAOIs and TCAs generally have more side effects than SSRIs. TCAs in particular have anticholinergic side effects such as constipation and blurred vision, whereas SSRIs are completely free of anticholinergic side effects.".
- Dirty_drug wikiPageID "8884051".
- Dirty_drug wikiPageLength "6726".
- Dirty_drug wikiPageOutDegree "37".
- Dirty_drug wikiPageRevisionID "679105717".
- Dirty_drug wikiPageWikiLink AG-013736.
- Dirty_drug wikiPageWikiLink Adverse_drug_reaction.
- Dirty_drug wikiPageWikiLink Alcohol.
- Dirty_drug wikiPageWikiLink Antibiotic.
- Dirty_drug wikiPageWikiLink Antibiotics.
- Dirty_drug wikiPageWikiLink Anticholinergic.
- Dirty_drug wikiPageWikiLink Antipsychotic.
- Dirty_drug wikiPageWikiLink Antitarget.
- Dirty_drug wikiPageWikiLink Antitussive.
- Dirty_drug wikiPageWikiLink Axitinib.
- Dirty_drug wikiPageWikiLink Biosynthesis.
- Dirty_drug wikiPageWikiLink Category:Drug_discovery.
- Dirty_drug wikiPageWikiLink Category:Pharmacodynamics.
- Dirty_drug wikiPageWikiLink Chemical_compound.
- Dirty_drug wikiPageWikiLink Chlorpromazine.
- Dirty_drug wikiPageWikiLink Clozapine.
- Dirty_drug wikiPageWikiLink Cochlea.
- Dirty_drug wikiPageWikiLink Collagen.
- Dirty_drug wikiPageWikiLink Cough_medicine.
- Dirty_drug wikiPageWikiLink DNA.
- Dirty_drug wikiPageWikiLink Deafness.
- Dirty_drug wikiPageWikiLink Dextromethorphan.
- Dirty_drug wikiPageWikiLink Dimebon.
- Dirty_drug wikiPageWikiLink Dissociative.
- Dirty_drug wikiPageWikiLink Drug.
- Dirty_drug wikiPageWikiLink Drugs.
- Dirty_drug wikiPageWikiLink Hair_cell.
- Dirty_drug wikiPageWikiLink Hearing_loss.
- Dirty_drug wikiPageWikiLink Hypertensive_crisis.
- Dirty_drug wikiPageWikiLink Ibogaine.
- Dirty_drug wikiPageWikiLink Kanamycin.
- Dirty_drug wikiPageWikiLink Latrepirdine.
- Dirty_drug wikiPageWikiLink MAOI.
- Dirty_drug wikiPageWikiLink Monoamine_oxidase_inhibitor.
- Dirty_drug wikiPageWikiLink Nicotine.
- Dirty_drug wikiPageWikiLink Opioid.
- Dirty_drug wikiPageWikiLink Opioids.
- Dirty_drug wikiPageWikiLink Outer_hair_cell.
- Dirty_drug wikiPageWikiLink Pharmacology.
- Dirty_drug wikiPageWikiLink Protein.
- Dirty_drug wikiPageWikiLink Proteins.
- Dirty_drug wikiPageWikiLink SSRI.
- Dirty_drug wikiPageWikiLink Selective_serotonin_reuptake_inhibitor.
- Dirty_drug wikiPageWikiLink Serotonin_syndrome.
- Dirty_drug wikiPageWikiLink Sorafenib.
- Dirty_drug wikiPageWikiLink Sunitinib.
- Dirty_drug wikiPageWikiLink Sutent.
- Dirty_drug wikiPageWikiLink Tricyclic_antidepressant.
- Dirty_drug wikiPageWikiLink Vandetanib.
- Dirty_drug wikiPageWikiLink Zactima.
- Dirty_drug wikiPageWikiLinkText "Dirty drug".
- Dirty_drug wikiPageWikiLinkText "dirty drug".
- Dirty_drug wikiPageWikiLinkText "dirty".
- Dirty_drug hasPhotoCollection Dirty_drug.
- Dirty_drug subject Category:Drug_discovery.
- Dirty_drug subject Category:Pharmacodynamics.
- Dirty_drug hypernym Term.
- Dirty_drug type Drug.
- Dirty_drug type Drug.
- Dirty_drug comment "In pharmacology, a dirty drug is an informal term for drugs that may bind to many different molecular targets or receptors in the body, and so tend to have a wide range of effects and possibly adverse drug reactions.".
- Dirty_drug label "Dirty drug".
- Dirty_drug sameAs Dirty_Drug.
- Dirty_drug sameAs m.027n6jb.
- Dirty_drug sameAs Dirty_drug.
- Dirty_drug sameAs Q1228218.
- Dirty_drug sameAs Q1228218.
- Dirty_drug wasDerivedFrom Dirty_drug?oldid=679105717.
- Dirty_drug isPrimaryTopicOf Dirty_drug.