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- Diphthamide abstract "Diphthamide is a modified histidine amino acid found in eukaryotic elongation factor 2 (eEF-2). It is usually found at position H715 in mammalian eEF2 (H699 in yeast). This residue is modified by the protein encoded by the DPH1 (OVCA1) gene. Dph1 knockout mice are inviable while heterozygotes develop diverse types of carcinomas and sarcomas. In humans, DH1 is frequently found mutated in ovarian cancer. Loss of heterozygosity has taken place in 50% of benign tumours, and 90% of end-stage ovarian tumours.It is ADP-ribosylated by diphtheria toxin, hence the name, which renders the elongation factor inactive.".
- Diphthamide iupacName "2-Amino-3-[2-(3-carbamoyl-3-trimethylammonio-propyl)-3H-imidazol-4-yl]propanoate".
- Diphthamide thumbnail Diphthamide.png?width=300.
- Diphthamide wikiPageID "11698208".
- Diphthamide wikiPageLength "2083".
- Diphthamide wikiPageOutDegree "16".
- Diphthamide wikiPageRevisionID "670387336".
- Diphthamide wikiPageWikiLink ADP-ribosylation.
- Diphthamide wikiPageWikiLink ADP_ribosylation.
- Diphthamide wikiPageWikiLink Amino_acid.
- Diphthamide wikiPageWikiLink Carcinoma.
- Diphthamide wikiPageWikiLink Category:Amino_acids.
- Diphthamide wikiPageWikiLink Category:Imidazoles.
- Diphthamide wikiPageWikiLink Category:Posttranslational_modification.
- Diphthamide wikiPageWikiLink Category:Quaternary_ammonium_compounds.
- Diphthamide wikiPageWikiLink DPH1.
- Diphthamide wikiPageWikiLink Diphtheria_toxin.
- Diphthamide wikiPageWikiLink EEF2.
- Diphthamide wikiPageWikiLink Heterozygote.
- Diphthamide wikiPageWikiLink Histidine.
- Diphthamide wikiPageWikiLink Knockout_mice.
- Diphthamide wikiPageWikiLink Knockout_mouse.
- Diphthamide wikiPageWikiLink Loss_of_heterozygosity.
- Diphthamide wikiPageWikiLink Ovarian_cancer.
- Diphthamide wikiPageWikiLink Sarcoma.
- Diphthamide wikiPageWikiLink Zygosity.
- Diphthamide wikiPageWikiLinkText "Diphthamide".
- Diphthamide wikiPageWikiLinkText "diphthamide".
- Diphthamide hasPhotoCollection Diphthamide.
- Diphthamide imagefile "diphthamide.png".
- Diphthamide imagesize "200".
- Diphthamide iupacname "2".
- Diphthamide verifiedrevid "428011922".
- Diphthamide watchedfields "changed".
- Diphthamide wikiPageUsesTemplate Template:Chembox.
- Diphthamide subject Category:Amino_acids.
- Diphthamide subject Category:Imidazoles.
- Diphthamide subject Category:Posttranslational_modification.
- Diphthamide subject Category:Quaternary_ammonium_compounds.
- Diphthamide type Biomolecule.
- Diphthamide type ChemicalCompound.
- Diphthamide type ChemicalSubstance.
- Diphthamide type Biomolecule.
- Diphthamide type Diazole.
- Diphthamide type ChemicalObject.
- Diphthamide type Thing.
- Diphthamide type Q11173.
- Diphthamide comment "Diphthamide is a modified histidine amino acid found in eukaryotic elongation factor 2 (eEF-2). It is usually found at position H715 in mammalian eEF2 (H699 in yeast). This residue is modified by the protein encoded by the DPH1 (OVCA1) gene. Dph1 knockout mice are inviable while heterozygotes develop diverse types of carcinomas and sarcomas. In humans, DH1 is frequently found mutated in ovarian cancer.".
- Diphthamide label "Diphthamide".
- Diphthamide sameAs Diphthamid.
- Diphthamide sameAs دیفتامید.
- Diphthamide sameAs Diftamide.
- Diphthamide sameAs m.02rpc3r.
- Diphthamide sameAs Дифтамид.
- Diphthamide sameAs Diftamid.
- Diphthamide sameAs Diftamid.
- Diphthamide sameAs Q61344.
- Diphthamide sameAs Q61344.
- Diphthamide wasDerivedFrom Diphthamide?oldid=670387336.
- Diphthamide depiction Diphthamide.png.
- Diphthamide isPrimaryTopicOf Diphthamide.