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- Dexpramipexole abstract "Dexpramipexole (KNS-760704) is a drug that was investigated by Knopp Biosciences and Biogen Idec for the treatment of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease. The drug failed to show efficacy in terms of function or survival in a Phase III study of patients with ALS.In September 2009, dexpramipexole received Fast Track designation for ALS from the U.S. Food and Drug Administration (FDA). It has received Orphan Drug designation by both the FDA and the European Medicines Agency. Dexpramipexole is a low molecular weight, water-soluble, orally bioavailable, renally excreted compound with linear pharmacokinetics, and has been shown to be well tolerated in human subject testing.KNS-760704 is the enantiomer of pramipexole, and has been shown to improve mitochondrial function and to confer significant cellular protection in neurons under stress. KNS-760704 was originally identified as a candidate therapy for ALS by James Bennett, M.D., Ph.D., then of the University of Virginia.A 2010 Phase II clinical trial involving 102 patients showed a slowing of ALS disease progression.In January 2013, Biogen Idec announced that it was discontinuing its development of dexpramipexole in ALS due to lack of efficacy in a Phase III study.".
- Dexpramipexole iupacName "(R)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine".
- Dexpramipexole thumbnail Dexpramipexole.png?width=300.
- Dexpramipexole wikiPageExternalLink dexpramipexole-dihydrochloride.pdf.
- Dexpramipexole wikiPageID "28624467".
- Dexpramipexole wikiPageLength "4471".
- Dexpramipexole wikiPageOutDegree "16".
- Dexpramipexole wikiPageRevisionID "649862289".
- Dexpramipexole wikiPageWikiLink Amyotrophic_lateral_sclerosis.
- Dexpramipexole wikiPageWikiLink Biogen.
- Dexpramipexole wikiPageWikiLink Biogen_Idec.
- Dexpramipexole wikiPageWikiLink Category:Enantiopure_drugs.
- Dexpramipexole wikiPageWikiLink Category:Thiazoles.
- Dexpramipexole wikiPageWikiLink Clinical_trial.
- Dexpramipexole wikiPageWikiLink Dihydrochloride.
- Dexpramipexole wikiPageWikiLink Enantiomer.
- Dexpramipexole wikiPageWikiLink European_Medicines_Agency.
- Dexpramipexole wikiPageWikiLink FDA_Fast_Track_Development_Program.
- Dexpramipexole wikiPageWikiLink Food_and_Drug_Administration.
- Dexpramipexole wikiPageWikiLink Hydrochloride.
- Dexpramipexole wikiPageWikiLink Orphan_Drug.
- Dexpramipexole wikiPageWikiLink Orphan_drug.
- Dexpramipexole wikiPageWikiLink Pharmacokinetics.
- Dexpramipexole wikiPageWikiLink Pramipexole.
- Dexpramipexole wikiPageWikiLink University_of_Virginia.
- Dexpramipexole wikiPageWikiLinkText "Dexpramipexole".
- Dexpramipexole wikiPageWikiLinkText "dexpramipexole".
- Dexpramipexole hasPhotoCollection Dexpramipexole.
- Dexpramipexole imagefile "Dexpramipexole.png".
- Dexpramipexole iupacname "-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine".
- Dexpramipexole verifiedfields "changed".
- Dexpramipexole verifiedrevid "444634214".
- Dexpramipexole watchedfields "changed".
- Dexpramipexole wikiPageUsesTemplate Template:Chembox.
- Dexpramipexole wikiPageUsesTemplate Template:Reflist.
- Dexpramipexole subject Category:Enantiopure_drugs.
- Dexpramipexole subject Category:Thiazoles.
- Dexpramipexole hypernym Drug.
- Dexpramipexole type ChemicalCompound.
- Dexpramipexole type ChemicalSubstance.
- Dexpramipexole type Drug.
- Dexpramipexole type Azole.
- Dexpramipexole type Heterocycle.
- Dexpramipexole type ChemicalObject.
- Dexpramipexole type Thing.
- Dexpramipexole type Q11173.
- Dexpramipexole comment "Dexpramipexole (KNS-760704) is a drug that was investigated by Knopp Biosciences and Biogen Idec for the treatment of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease. The drug failed to show efficacy in terms of function or survival in a Phase III study of patients with ALS.In September 2009, dexpramipexole received Fast Track designation for ALS from the U.S. Food and Drug Administration (FDA).".
- Dexpramipexole label "Dexpramipexole".
- Dexpramipexole sameAs m.0czf547.
- Dexpramipexole sameAs Dekspramipeksol.
- Dexpramipexole sameAs Dekspramipeksol.
- Dexpramipexole sameAs Q5268345.
- Dexpramipexole sameAs Q5268345.
- Dexpramipexole wasDerivedFrom Dexpramipexole?oldid=649862289.
- Dexpramipexole depiction Dexpramipexole.png.
- Dexpramipexole isPrimaryTopicOf Dexpramipexole.