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- Dermaseptin abstract "Dermaseptins are a family of peptides isolated from skin of the Phyllomedusa genus of frogs.The sequence of the dermaseptins varies greatly but due to the presence of lysine residues all are cationic and most have the potential to form amphipathic helices in water or when integrated with the lipid bilayer of the bacterial membrane. Clear separation of two lobes of positive and negative intramolecular electrostatic potential is thought to be important in cytotoxic activity. Dermaseptins are typically 27-34 amino acid residues in length and were the first vertebrate peptides demonstrated as having a lethal effect on the filamentous fungi implicated in severe opportunistic infections accompanying immunodeficiency syndrome and immunosuppressive drug therapy.Dermaseptin use in a novel drug delivery system has been proposed. The system is based on the affinity of dermaseptins for the plasma membrane of human erythrocytes. After transient loading of the cells with the non-toxic dermaseptin S4 analogue K4–S4(1–13)a, the peptide is transported in the systemic circulation to distant microbial targets. Upon reaching a microorganism for which it has greater affinity the dermaseptin derivative is spontaneously transferred to the microbial membrane where it exerts its membrane-lytic activity. In their 2001 article, Feder et al. also discussed a broader application of peptides such as this analogue in the targeting of drug molecules. This “affinity driven molecular transfer” would involve attaching a drug to the peptide which then transports it to the desired site of action.".
- Dermaseptin symbol "DD_K".
- Dermaseptin wikiPageID "12023401".
- Dermaseptin wikiPageLength "2934".
- Dermaseptin wikiPageOutDegree "7".
- Dermaseptin wikiPageRevisionID "670686589".
- Dermaseptin wikiPageWikiLink Amino_acid.
- Dermaseptin wikiPageWikiLink Category:Peptides.
- Dermaseptin wikiPageWikiLink Category:Vertebrate_toxins.
- Dermaseptin wikiPageWikiLink Lipid_bilayer.
- Dermaseptin wikiPageWikiLink Lysine.
- Dermaseptin wikiPageWikiLink Peptide.
- Dermaseptin wikiPageWikiLink Phyllomedusa.
- Dermaseptin wikiPageWikiLinkText "dermaseptin".
- Dermaseptin hasPhotoCollection Dermaseptin.
- Dermaseptin name "Dermaseptin".
- Dermaseptin opmFamily "309".
- Dermaseptin opmProtein "2".
- Dermaseptin pfam "PF12121".
- Dermaseptin symbol "DD_K".
- Dermaseptin tcdb "1".
- Dermaseptin wikiPageUsesTemplate Template:Infobox_protein_family.
- Dermaseptin wikiPageUsesTemplate Template:Pore-forming_toxins.
- Dermaseptin wikiPageUsesTemplate Template:Reflist.
- Dermaseptin subject Category:Peptides.
- Dermaseptin subject Category:Vertebrate_toxins.
- Dermaseptin hypernym Family.
- Dermaseptin type Biomolecule.
- Dermaseptin type Protein.
- Dermaseptin type Biomolecule.
- Dermaseptin type Peptide.
- Dermaseptin type Toxin.
- Dermaseptin type Thing.
- Dermaseptin type Q206229.
- Dermaseptin type Q8054.
- Dermaseptin comment "Dermaseptins are a family of peptides isolated from skin of the Phyllomedusa genus of frogs.The sequence of the dermaseptins varies greatly but due to the presence of lysine residues all are cationic and most have the potential to form amphipathic helices in water or when integrated with the lipid bilayer of the bacterial membrane. Clear separation of two lobes of positive and negative intramolecular electrostatic potential is thought to be important in cytotoxic activity.".
- Dermaseptin label "Dermaseptin".
- Dermaseptin sameAs Dermaseptine.
- Dermaseptin sameAs Dermaseptina.
- Dermaseptin sameAs m.02vm7hm.
- Dermaseptin sameAs Q3023824.
- Dermaseptin sameAs Q3023824.
- Dermaseptin wasDerivedFrom Dermaseptin?oldid=670686589.
- Dermaseptin isPrimaryTopicOf Dermaseptin.