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- Demethylating_agent abstract "Demethylating agents are compounds that can inhibit methylation, resulting in the expression of the previously hypermethylated silenced genes (see Methylation#Cancer for more detail). Cytidine analogs such as 5-azacytidine (azacitidine) and 5-azadeoxycytidine (decitabine) are the most commonly used demethylating agents . These compounds work by binding to the enzymes that catalyse the methylation reaction, DNA methyltransferases; and titrate out these enzymes. Both compounds have been approved in the treatment of Myelodysplastic syndrome (MDS) by Food and Drug Administration (FDA) in United States. Azacitidine and decitabine are marketed as Vidaza and Dacogen respectively. Azacitidine is the first drug to be approved by FDA for treating MDS and has been given orphan drug status. Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells.".
- Demethylating_agent wikiPageID "16818152".
- Demethylating_agent wikiPageLength "2062".
- Demethylating_agent wikiPageOutDegree "19".
- Demethylating_agent wikiPageRevisionID "674461893".
- Demethylating_agent wikiPageWikiLink 5-azacytidine.
- Demethylating_agent wikiPageWikiLink Azacitidine.
- Demethylating_agent wikiPageWikiLink Catalyse.
- Demethylating_agent wikiPageWikiLink Catalysis.
- Demethylating_agent wikiPageWikiLink Category:Biochemistry.
- Demethylating_agent wikiPageWikiLink Chemical_compound.
- Demethylating_agent wikiPageWikiLink Cytidine.
- Demethylating_agent wikiPageWikiLink DNA_methyltransferase.
- Demethylating_agent wikiPageWikiLink Decitabine.
- Demethylating_agent wikiPageWikiLink Enzyme.
- Demethylating_agent wikiPageWikiLink Enzymes.
- Demethylating_agent wikiPageWikiLink Food_and_Drug_Administration.
- Demethylating_agent wikiPageWikiLink Gene.
- Demethylating_agent wikiPageWikiLink Genes.
- Demethylating_agent wikiPageWikiLink Methylation.
- Demethylating_agent wikiPageWikiLink Myelodysplastic_syndrome.
- Demethylating_agent wikiPageWikiLink Orphan_drug.
- Demethylating_agent wikiPageWikiLink Procaine.
- Demethylating_agent wikiPageWikiLinkText "Demethylating agent".
- Demethylating_agent hasPhotoCollection Demethylating_agent.
- Demethylating_agent wikiPageUsesTemplate Template:Reflist.
- Demethylating_agent subject Category:Biochemistry.
- Demethylating_agent hypernym Compounds.
- Demethylating_agent type ChemicalCompound.
- Demethylating_agent comment "Demethylating agents are compounds that can inhibit methylation, resulting in the expression of the previously hypermethylated silenced genes (see Methylation#Cancer for more detail). Cytidine analogs such as 5-azacytidine (azacitidine) and 5-azadeoxycytidine (decitabine) are the most commonly used demethylating agents . These compounds work by binding to the enzymes that catalyse the methylation reaction, DNA methyltransferases; and titrate out these enzymes.".
- Demethylating_agent label "Demethylating agent".
- Demethylating_agent sameAs m.0407b4z.
- Demethylating_agent sameAs Q5255196.
- Demethylating_agent sameAs Q5255196.
- Demethylating_agent wasDerivedFrom Demethylating_agent?oldid=674461893.
- Demethylating_agent isPrimaryTopicOf Demethylating_agent.