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- Deleobuvir abstract "Deleobuvir (formerly BI 207127) was an experimental drug for the treatment of hepatitis C. It was being developed by Boehringer-Ingelheim. It is a non-nucleoside hepatitis C virus NS5B polymerase inhibitor. Deleobuvir was tested in combination regimens with pegylated interferon and ribavirin, and in interferon-free regimens with other direct-acting antiviral agents including faldaprevir.Data from the SOUND-C2 study, presented at the 2012 AASLD Liver Meeting, showed that a triple combination of deleobuvir, faldaprevir, and ribavirin performed well in HCV genotype 1b patients. Efficacy fell below 50%, however, for dual regimens without ribavirin and for genotype 1a patients.These results were confirmed in the SOUND-C3 study, presented at the 2013 APASL Liver Conference, which found that 16 week triple therapy with deleobuvir + faldaprevir + ribavirin gave 95% SVR12 in HCV genotype 1b patients but poor virological response in genotype 1a.In December 2013, Boehringer Ingelheim announced that the development of deleobuvir would not be continued since recent findings from phase III trials did not suggest sufficient efficacy.".
- Deleobuvir atcPrefix "None".
- Deleobuvir casNumber "863884-77-9".
- Deleobuvir fdaUniiCode "58BU988K90".
- Deleobuvir iupacName "(2E)-3-(2-{1-[2-(5-Bromopyrimidin-2-yl)-3-cyclopentyl-1-methyl-1H-indole-6-carboxamido]cyclobutyl}-1-methyl-1H-benzimidazol- 6-yl)prop-2-enoic acid".
- Deleobuvir thumbnail Deleobuvir.svg?width=300.
- Deleobuvir wikiPageID "38750510".
- Deleobuvir wikiPageLength "4353".
- Deleobuvir wikiPageOutDegree "16".
- Deleobuvir wikiPageRevisionID "667986987".
- Deleobuvir wikiPageWikiLink AASLD.
- Deleobuvir wikiPageWikiLink American_Association_for_the_Study_of_Liver_Diseases.
- Deleobuvir wikiPageWikiLink Boehringer-Ingelheim.
- Deleobuvir wikiPageWikiLink Boehringer_Ingelheim.
- Deleobuvir wikiPageWikiLink Category:Benzimidazoles.
- Deleobuvir wikiPageWikiLink Category:NS5A_inhibitors.
- Deleobuvir wikiPageWikiLink Category:Organobromides.
- Deleobuvir wikiPageWikiLink Category:Pyrazines.
- Deleobuvir wikiPageWikiLink Drug_development.
- Deleobuvir wikiPageWikiLink Faldaprevir.
- Deleobuvir wikiPageWikiLink Hepatitis_C.
- Deleobuvir wikiPageWikiLink Hepatitis_C_virus.
- Deleobuvir wikiPageWikiLink Pegylated_interferon.
- Deleobuvir wikiPageWikiLink Ribavirin.
- Deleobuvir wikiPageWikiLinkText "Deleobuvir".
- Deleobuvir atcPrefix "None".
- Deleobuvir br "1".
- Deleobuvir c "34".
- Deleobuvir casNumber "863884".
- Deleobuvir chembl "2403318".
- Deleobuvir chemspiderid "29773345".
- Deleobuvir drugName "Deleobuvir".
- Deleobuvir h "33".
- Deleobuvir hasPhotoCollection Deleobuvir.
- Deleobuvir inchi "1".
- Deleobuvir inchikey "BMAIGAHXAJEULY-UKTHLTGXBE".
- Deleobuvir iupacName "-3".
- Deleobuvir legalStatus "Investigational".
- Deleobuvir molecularWeight "653.568".
- Deleobuvir n "6".
- Deleobuvir o "3".
- Deleobuvir pregnancyCategory "N/A".
- Deleobuvir smiles "CN1C2=CCC7CCCC7".
- Deleobuvir stdinchi "1".
- Deleobuvir stdinchikey "BMAIGAHXAJEULY-UKTHLTGXSA-N".
- Deleobuvir unii "58".
- Deleobuvir width "300".
- Deleobuvir wikiPageUsesTemplate Template:Antiinfective-drug-stub.
- Deleobuvir wikiPageUsesTemplate Template:Drugbox.
- Deleobuvir wikiPageUsesTemplate Template:RNA_antivirals.
- Deleobuvir wikiPageUsesTemplate Template:Reflist.
- Deleobuvir subject Category:Benzimidazoles.
- Deleobuvir subject Category:NS5A_inhibitors.
- Deleobuvir subject Category:Organobromides.
- Deleobuvir subject Category:Pyrazines.
- Deleobuvir hypernym Drug.
- Deleobuvir type ChemicalSubstance.
- Deleobuvir type Drug.
- Deleobuvir type ChemicalObject.
- Deleobuvir type Thing.
- Deleobuvir type Q8386.
- Deleobuvir comment "Deleobuvir (formerly BI 207127) was an experimental drug for the treatment of hepatitis C. It was being developed by Boehringer-Ingelheim. It is a non-nucleoside hepatitis C virus NS5B polymerase inhibitor.".
- Deleobuvir label "Deleobuvir".
- Deleobuvir sameAs m.0rf84d4.
- Deleobuvir sameAs Q15708312.
- Deleobuvir sameAs Q15708312.
- Deleobuvir wasDerivedFrom Deleobuvir?oldid=667986987.
- Deleobuvir depiction Deleobuvir.svg.
- Deleobuvir isPrimaryTopicOf Deleobuvir.
- Deleobuvir name "Deleobuvir".