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- DUSP3 abstract "Dual specificity protein phosphatase 3 is an enzyme that in humans is encoded by the DUSP3 gene.The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1.".
- DUSP3 entrezgene "1845".
- DUSP3 wikiPageID "14817162".
- DUSP3 wikiPageLength "14187".
- DUSP3 wikiPageOutDegree "33".
- DUSP3 wikiPageRevisionID "678196725".
- DUSP3 wikiPageWikiLink Antibody.
- DUSP3 wikiPageWikiLink Auditory_brainstem_response.
- DUSP3 wikiPageWikiLink Bacterial_infection.
- DUSP3 wikiPageWikiLink Blood_plasma.
- DUSP3 wikiPageWikiLink Category:Genes_mutated_in_mice.
- DUSP3 wikiPageWikiLink Citrobacter.
- DUSP3 wikiPageWikiLink Clinical_chemistry.
- DUSP3 wikiPageWikiLink Corpus_callosum.
- DUSP3 wikiPageWikiLink Dual-energy_X-ray_absorptiometry.
- DUSP3 wikiPageWikiLink Dysmorphology.
- DUSP3 wikiPageWikiLink Enzyme.
- DUSP3 wikiPageWikiLink Gene.
- DUSP3 wikiPageWikiLink Glucose_tolerance_test.
- DUSP3 wikiPageWikiLink Haematology.
- DUSP3 wikiPageWikiLink Hematology.
- DUSP3 wikiPageWikiLink Homozygote.
- DUSP3 wikiPageWikiLink Homozygous.
- DUSP3 wikiPageWikiLink Hot_plate_test.
- DUSP3 wikiPageWikiLink Humerus.
- DUSP3 wikiPageWikiLink Immunoglobulin.
- DUSP3 wikiPageWikiLink Indirect_calorimetry.
- DUSP3 wikiPageWikiLink International_Knockout_Mouse_Consortium.
- DUSP3 wikiPageWikiLink Knockout_mouse.
- DUSP3 wikiPageWikiLink MAPK1.
- DUSP3 wikiPageWikiLink MAPK3.
- DUSP3 wikiPageWikiLink Micronucleus_test.
- DUSP3 wikiPageWikiLink Model_organism.
- DUSP3 wikiPageWikiLink Mutant.
- DUSP3 wikiPageWikiLink Open_Field_(animal_test).
- DUSP3 wikiPageWikiLink Pathogenic_bacteria.
- DUSP3 wikiPageWikiLink Peripheral_blood_lymphocyte.
- DUSP3 wikiPageWikiLink Phenotypic_screen.
- DUSP3 wikiPageWikiLink Phenotypic_screening.
- DUSP3 wikiPageWikiLink Protein-protein_interaction.
- DUSP3 wikiPageWikiLink Protein–protein_interaction.
- DUSP3 wikiPageWikiLink Pyramidal_cell.
- DUSP3 wikiPageWikiLink Radiography.
- DUSP3 wikiPageWikiLink Salmonella.
- DUSP3 wikiPageWikiLink Teratology.
- DUSP3 wikiPageWikiLink Zygosity.
- DUSP3 wikiPageWikiLinkText "DUSP3".
- DUSP3 hasPhotoCollection DUSP3.
- DUSP3 requireManualInspection "no".
- DUSP3 summaryText "The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein kinase superfamily , which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1.".
- DUSP3 updateCitations "yes".
- DUSP3 updatePage "yes".
- DUSP3 updateProteinBox "yes".
- DUSP3 updateSummary "yes".
- DUSP3 wikiPageUsesTemplate Template:Gene-17-stub.
- DUSP3 wikiPageUsesTemplate Template:PBB.
- DUSP3 wikiPageUsesTemplate Template:PBB_Controls.
- DUSP3 wikiPageUsesTemplate Template:PBB_Further_reading.
- DUSP3 wikiPageUsesTemplate Template:PBB_Summary.
- DUSP3 wikiPageUsesTemplate Template:PDB_Gallery.
- DUSP3 wikiPageUsesTemplate Template:Protein_tyrosine_phosphatases.
- DUSP3 wikiPageUsesTemplate Template:Refbegin.
- DUSP3 wikiPageUsesTemplate Template:Refend.
- DUSP3 wikiPageUsesTemplate Template:Reflist.
- DUSP3 subject Category:Genes_mutated_in_mice.
- DUSP3 hypernym Enzyme.
- DUSP3 type Article.
- DUSP3 type Biomolecule.
- DUSP3 type Protein.
- DUSP3 type Article.
- DUSP3 type Thing.
- DUSP3 type Q206229.
- DUSP3 type Q8054.
- DUSP3 comment "Dual specificity protein phosphatase 3 is an enzyme that in humans is encoded by the DUSP3 gene.The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues.".
- DUSP3 label "DUSP3".
- DUSP3 sameAs DUSP3.
- DUSP3 sameAs m.03gyz1g.
- DUSP3 sameAs Q5206319.
- DUSP3 sameAs Q5206319.
- DUSP3 wasDerivedFrom DUSP3?oldid=678196725.
- DUSP3 isPrimaryTopicOf DUSP3.