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- DOV-216,303 abstract "DOV 216,303 is an antidepressant drug originally developed by DOV Pharmaceutical and now licensed to the larger pharmaceutical company Merck & Co., which is currently in clinical trials. It is a so-called triple reuptake inhibitor (TRI), or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI). It is the racemic mixture of amitifadine (DOV 21,947) and its (–)-enantiomer. Its IC50 values for SERT, NET, and DAT are Ki 14 nM, 20 nM, and 78 nM, respectively. It is closely related to DOV 102,677 and amitifadine, both of which are also being developed in collaboration with Merck.500pxDoses of up to 100 mg per day are well tolerated with only nausea, and GI disturbances reported as side effects.This compound does not cause notable shifts in LMA, and is not psychostimulant.The effects are not long-lasting.More recently (see attachment), it appears that the DOV compound may also be useful at increasing weight loss.DOV causes a decrease in circulating triglycerides.The reason for weightloss is not going to be thermogenic or psychostimulant, or chronic decrease appetite. Read article for details.↑ 1.0 1.1 ↑ 2.0 2.1".
- DOV-216,303 atcPrefix "none".
- DOV-216,303 iupacName "1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane".
- DOV-216,303 pubchem "9795276".
- DOV-216,303 thumbnail DOV-216,303_structure.png?width=300.
- DOV-216,303 wikiPageID "22603947".
- DOV-216,303 wikiPageLength "3570".
- DOV-216,303 wikiPageOutDegree "20".
- DOV-216,303 wikiPageRevisionID "670674076".
- DOV-216,303 wikiPageWikiLink Amitifadine.
- DOV-216,303 wikiPageWikiLink Antidepressant.
- DOV-216,303 wikiPageWikiLink Bicifadine.
- DOV-216,303 wikiPageWikiLink Category:Chloroarenes.
- DOV-216,303 wikiPageWikiLink Category:Pyrrolidines.
- DOV-216,303 wikiPageWikiLink Category:Serotonin-norepinephrine-dopamine_reuptake_inhibitors.
- DOV-216,303 wikiPageWikiLink Clinical_trial.
- DOV-216,303 wikiPageWikiLink Clinical_trials.
- DOV-216,303 wikiPageWikiLink DOV-102,677.
- DOV-216,303 wikiPageWikiLink DOV_102,677.
- DOV-216,303 wikiPageWikiLink DOV_Pharmaceutical.
- DOV-216,303 wikiPageWikiLink Dopamine_transporter.
- DOV-216,303 wikiPageWikiLink Drug.
- DOV-216,303 wikiPageWikiLink Enantiomer.
- DOV-216,303 wikiPageWikiLink IC50.
- DOV-216,303 wikiPageWikiLink Merck_&_Co..
- DOV-216,303 wikiPageWikiLink Norepinephrine_transporter.
- DOV-216,303 wikiPageWikiLink Racemic.
- DOV-216,303 wikiPageWikiLink Racemic_mixture.
- DOV-216,303 wikiPageWikiLink Serotonin-norepinephrine-dopamine_reuptake_inhibitor.
- DOV-216,303 wikiPageWikiLink Serotonin_transporter.
- DOV-216,303 wikiPageWikiLink Serotonin–norepinephrine–dopamine_reuptake_inhibitor.
- DOV-216,303 wikiPageWikiLink File:DOV_stereochemistry.svg.
- DOV-216,303 wikiPageWikiLinkText "DOV-216,303".
- DOV-216,303 atcPrefix "none".
- DOV-216,303 c "11".
- DOV-216,303 cl "2".
- DOV-216,303 h "11".
- DOV-216,303 hasPhotoCollection DOV-216,303.
- DOV-216,303 iupacName "1".
- DOV-216,303 molecularWeight "228.117".
- DOV-216,303 n "1".
- DOV-216,303 pubchem "9795276".
- DOV-216,303 smiles "C3C2CNCC23cccc1Cl".
- DOV-216,303 verifiedrevid "402699925".
- DOV-216,303 watchedfields "changed".
- DOV-216,303 width "160".
- DOV-216,303 wikiPageUsesTemplate Template:Adrenergics.
- DOV-216,303 wikiPageUsesTemplate Template:Drugbox.
- DOV-216,303 wikiPageUsesTemplate Template:Multiple_issues.
- DOV-216,303 wikiPageUsesTemplate Template:Nervous-system-drug-stub.
- DOV-216,303 wikiPageUsesTemplate Template:Reflist.
- DOV-216,303 subject Category:Chloroarenes.
- DOV-216,303 subject Category:Pyrrolidines.
- DOV-216,303 subject Category:Serotonin-norepinephrine-dopamine_reuptake_inhibitors.
- DOV-216,303 hypernym Drug.
- DOV-216,303 type ChemicalSubstance.
- DOV-216,303 type Drug.
- DOV-216,303 type ChemicalObject.
- DOV-216,303 type Thing.
- DOV-216,303 type Q8386.
- DOV-216,303 comment "DOV 216,303 is an antidepressant drug originally developed by DOV Pharmaceutical and now licensed to the larger pharmaceutical company Merck & Co., which is currently in clinical trials. It is a so-called triple reuptake inhibitor (TRI), or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI). It is the racemic mixture of amitifadine (DOV 21,947) and its (–)-enantiomer. Its IC50 values for SERT, NET, and DAT are Ki 14 nM, 20 nM, and 78 nM, respectively.".
- DOV-216,303 label "DOV-216,303".
- DOV-216,303 sameAs m.05zzp04.
- DOV-216,303 sameAs DOV-216,303.
- DOV-216,303 sameAs DOV-216,303.
- DOV-216,303 sameAs Q5205904.
- DOV-216,303 sameAs Q5205904.
- DOV-216,303 wasDerivedFrom DOV-216,303?oldid=670674076.
- DOV-216,303 depiction DOV-216,303_structure.png.
- DOV-216,303 isPrimaryTopicOf DOV-216,303.