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- DLX6-AS1 abstract "DLX6 antisense RNA 1 (DLX6-AS1) (Evf-1 (Embryonic ventral forebrain-1)) is a developmentally-regulated long non-coding RNA. In rats, it is expressed in neurons in the subventricular zone of the developing forebrain. Its expression is linked to that of the Shh (sonic hedgehog) and DLX families of genes, which are important in ventral forebrain and craniofacial development. An alternatively spliced form of DLX6-AS1, DLX6-AS2, forms a stable complex with the Dlx-2 protein. This complex activates transcription of Dlx-5 and Dlx-6.DLX6-AS2 regulates gene expression in a region of the brain which produces GABAergic interneurons during development. It is involved in the signaling pathway and works in conjunction with DLX homeodomain proteins to increase the effectiveness of the Dlx5/6 enhancer element within neural stem cells. The interneurons are found in the hippocampus of the adult brain, an area responsible for learning and memory.GABAergic interneurons have been implicated in a number of psychiatric disorders including autism, schizophrenia and epilepsy; as DLX6-AS2 controls the development of these neurones, it has been subject to studies regarding the causation of these disorders.DLX6-AS2 is the first known long non-coding RNA to be involved in organogenesis.".
- DLX6-AS1 thumbnail Evf2-ss-cons.png?width=300.
- DLX6-AS1 wikiPageExternalLink pmidlookup?view=long&pmid=9811591.
- DLX6-AS1 wikiPageExternalLink 151.
- DLX6-AS1 wikiPageExternalLink pmidlookup?view=long&pmid=11731473.
- DLX6-AS1 wikiPageID "28157753".
- DLX6-AS1 wikiPageLength "6229".
- DLX6-AS1 wikiPageOutDegree "27".
- DLX6-AS1 wikiPageRevisionID "661001219".
- DLX6-AS1 wikiPageWikiLink Autism.
- DLX6-AS1 wikiPageWikiLink Category:Non-coding_RNA.
- DLX6-AS1 wikiPageWikiLink Chemoaffinity_hypothesis.
- DLX6-AS1 wikiPageWikiLink Craniofacial.
- DLX6-AS1 wikiPageWikiLink DLX_gene_family.
- DLX6-AS1 wikiPageWikiLink Dlx_(gene).
- DLX6-AS1 wikiPageWikiLink Epilepsy.
- DLX6-AS1 wikiPageWikiLink Forebrain.
- DLX6-AS1 wikiPageWikiLink Gamma-Aminobutyric_acid.
- DLX6-AS1 wikiPageWikiLink Gene.
- DLX6-AS1 wikiPageWikiLink Gene_expression.
- DLX6-AS1 wikiPageWikiLink Genes.
- DLX6-AS1 wikiPageWikiLink Hippocampus.
- DLX6-AS1 wikiPageWikiLink Homeobox.
- DLX6-AS1 wikiPageWikiLink Homeodomain.
- DLX6-AS1 wikiPageWikiLink Interneuron.
- DLX6-AS1 wikiPageWikiLink Interneurons.
- DLX6-AS1 wikiPageWikiLink Learning.
- DLX6-AS1 wikiPageWikiLink Long_non-coding_RNA.
- DLX6-AS1 wikiPageWikiLink Long_noncoding_RNA.
- DLX6-AS1 wikiPageWikiLink Mammal.
- DLX6-AS1 wikiPageWikiLink Mammalia.
- DLX6-AS1 wikiPageWikiLink Memory.
- DLX6-AS1 wikiPageWikiLink Mental_disorder.
- DLX6-AS1 wikiPageWikiLink Neuron.
- DLX6-AS1 wikiPageWikiLink Organogenesis.
- DLX6-AS1 wikiPageWikiLink Psychiatric_disorders.
- DLX6-AS1 wikiPageWikiLink Rat.
- DLX6-AS1 wikiPageWikiLink Schizophrenia.
- DLX6-AS1 wikiPageWikiLink Sonic_hedgehog.
- DLX6-AS1 wikiPageWikiLink Stem_cell.
- DLX6-AS1 wikiPageWikiLinkText "DLX6-AS1".
- DLX6-AS1 caption "Conserved secondary structure of Evf2 RNA.".
- DLX6-AS1 hasPhotoCollection DLX6-AS1.
- DLX6-AS1 id "RF01887".
- DLX6-AS1 name "Embryonic ventral forebrain RNA 1 conserved region 1".
- DLX6-AS1 name "Evf-2".
- DLX6-AS1 rfam "RF01887".
- DLX6-AS1 rnaType "RNA gene".
- DLX6-AS1 symbol "Evf-2".
- DLX6-AS1 taxDomain Mammal.
- DLX6-AS1 taxDomain Mammalia.
- DLX6-AS1 wikiPageUsesTemplate Template:Cite_journal.
- DLX6-AS1 wikiPageUsesTemplate Template:Infobox_rfam.
- DLX6-AS1 wikiPageUsesTemplate Template:Refbegin.
- DLX6-AS1 wikiPageUsesTemplate Template:Refend.
- DLX6-AS1 wikiPageUsesTemplate Template:Reflist.
- DLX6-AS1 wikiPageUsesTemplate Template:Rfam.
- DLX6-AS1 subject Category:Non-coding_RNA.
- DLX6-AS1 hypernym RNA.
- DLX6-AS1 type Protein.
- DLX6-AS1 comment "DLX6 antisense RNA 1 (DLX6-AS1) (Evf-1 (Embryonic ventral forebrain-1)) is a developmentally-regulated long non-coding RNA. In rats, it is expressed in neurons in the subventricular zone of the developing forebrain. Its expression is linked to that of the Shh (sonic hedgehog) and DLX families of genes, which are important in ventral forebrain and craniofacial development. An alternatively spliced form of DLX6-AS1, DLX6-AS2, forms a stable complex with the Dlx-2 protein.".
- DLX6-AS1 label "DLX6-AS1".
- DLX6-AS1 sameAs m.0cm94yd.
- DLX6-AS1 sameAs Q5418212.
- DLX6-AS1 sameAs Q5418212.
- DLX6-AS1 wasDerivedFrom DLX6-AS1?oldid=661001219.
- DLX6-AS1 depiction Evf2-ss-cons.png.
- DLX6-AS1 isPrimaryTopicOf DLX6-AS1.