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- DIRAS3_(gene) abstract "GTP-binding protein Di-Ras3 (DIRAS3) also known as aplysia ras homology member I (ARHI) is a protein that in humans is encoded by the DIRAS3 gene.This gene is a member of the ras superfamily, and is expressed in normal ovarian and breast epithelial cells, but not in ovarian and breast cancers. It is an imprinted gene, with monoallelic expression of the paternal allele, which is associated with growth suppression. Thus, this gene appears to be a putative tumor suppressor gene whose function is abrogated in ovarian and breast cancers.It is maternally imprinted, and is linked to breast cancer as well as ovarian cancer. The ARHI gene includes one promoter, two exons and one intron with a 687 bp protein-coding region that encodes a 26-kDa protein. The ARHI protein (italic for gene, nonitalic for protein) is a GTPase belonging to the Ras superfamily and shares 50-60% homology with Ras and Rap, two other small GTP binding proteins. This gene is a maternally imprinted putative tumor suppressor, and reduced expression of ARHI has been reported in 70% of invasive breast cancers.".
- DIRAS3_(gene) entrezgene "9077".
- DIRAS3_(gene) wikiPageID "40256844".
- DIRAS3_(gene) wikiPageLength "11647".
- DIRAS3_(gene) wikiPageOutDegree "28".
- DIRAS3_(gene) wikiPageRevisionID "674582256".
- DIRAS3_(gene) wikiPageWikiLink Alanine.
- DIRAS3_(gene) wikiPageWikiLink Amino_acid.
- DIRAS3_(gene) wikiPageWikiLink Amino_acid_residue.
- DIRAS3_(gene) wikiPageWikiLink Base_pair.
- DIRAS3_(gene) wikiPageWikiLink Breast_cancer.
- DIRAS3_(gene) wikiPageWikiLink C-Jun_N-terminal_kinases.
- DIRAS3_(gene) wikiPageWikiLink Category:Genes_on_human_chromosome_1.
- DIRAS3_(gene) wikiPageWikiLink Cyclin_D1.
- DIRAS3_(gene) wikiPageWikiLink Downregulated.
- DIRAS3_(gene) wikiPageWikiLink Downregulation_and_upregulation.
- DIRAS3_(gene) wikiPageWikiLink Epigenetic.
- DIRAS3_(gene) wikiPageWikiLink Epigenetics.
- DIRAS3_(gene) wikiPageWikiLink Epithelial_cells.
- DIRAS3_(gene) wikiPageWikiLink Epithelium.
- DIRAS3_(gene) wikiPageWikiLink GTPase.
- DIRAS3_(gene) wikiPageWikiLink Gene.
- DIRAS3_(gene) wikiPageWikiLink Genomic_imprinting.
- DIRAS3_(gene) wikiPageWikiLink Glutamine.
- DIRAS3_(gene) wikiPageWikiLink Glycine.
- DIRAS3_(gene) wikiPageWikiLink Imprinting_(genetics).
- DIRAS3_(gene) wikiPageWikiLink JNK.
- DIRAS3_(gene) wikiPageWikiLink Knudson_hypothesis.
- DIRAS3_(gene) wikiPageWikiLink Lysine.
- DIRAS3_(gene) wikiPageWikiLink ERK_pathway.
- DIRAS3_(gene) wikiPageWikiLink N-terminus.
- DIRAS3_(gene) wikiPageWikiLink Ovarian_cancer.
- DIRAS3_(gene) wikiPageWikiLink P21.
- DIRAS3_(gene) wikiPageWikiLink Protein.
- DIRAS3_(gene) wikiPageWikiLink Protein_domain.
- DIRAS3_(gene) wikiPageWikiLink Ras_superfamily.
- DIRAS3_(gene) wikiPageWikiLink Upregulated.
- DIRAS3_(gene) wikiPageWikiLinkText "DIRAS3 (gene)".
- DIRAS3_(gene) wikiPageWikiLinkText "DIRAS3_(gene)".
- DIRAS3_(gene) hasPhotoCollection DIRAS3_(gene).
- DIRAS3_(gene) wikiPageUsesTemplate Template:By_whom.
- DIRAS3_(gene) wikiPageUsesTemplate Template:Cite_journal.
- DIRAS3_(gene) wikiPageUsesTemplate Template:MeshName.
- DIRAS3_(gene) wikiPageUsesTemplate Template:NLM_content.
- DIRAS3_(gene) wikiPageUsesTemplate Template:PBB.
- DIRAS3_(gene) wikiPageUsesTemplate Template:Refbegin.
- DIRAS3_(gene) wikiPageUsesTemplate Template:Refend.
- DIRAS3_(gene) wikiPageUsesTemplate Template:Reflist.
- DIRAS3_(gene) subject Category:Genes_on_human_chromosome_1.
- DIRAS3_(gene) hypernym Protein.
- DIRAS3_(gene) type Biomolecule.
- DIRAS3_(gene) type Protein.
- DIRAS3_(gene) type Thing.
- DIRAS3_(gene) type Q206229.
- DIRAS3_(gene) type Q8054.
- DIRAS3_(gene) comment "GTP-binding protein Di-Ras3 (DIRAS3) also known as aplysia ras homology member I (ARHI) is a protein that in humans is encoded by the DIRAS3 gene.This gene is a member of the ras superfamily, and is expressed in normal ovarian and breast epithelial cells, but not in ovarian and breast cancers. It is an imprinted gene, with monoallelic expression of the paternal allele, which is associated with growth suppression.".
- DIRAS3_(gene) label "DIRAS3 (gene)".
- DIRAS3_(gene) sameAs m.0wqd3n6.
- DIRAS3_(gene) sameAs Q15996612.
- DIRAS3_(gene) sameAs Q15996612.
- DIRAS3_(gene) wasDerivedFrom DIRAS3_(gene)?oldid=674582256.
- DIRAS3_(gene) isPrimaryTopicOf DIRAS3_(gene).