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- DCTN6 abstract "DCTN6 is the gene of p27 subunit of the dynactin complex, which is the essential component for microtubule-based cytoplasmic dynein motor activity in transport of variety of intracellular cargoes and organelle. It is first identified and cloned as a subunit of the "pointed-end complex" of dynactin through biochemical purification. Dynactin p27 forms a hetero-dimer with the other dynactin pointed-end complex subunit p25/DCTN5 in 1:1 ratio, and it is essential for p25 stability since they are co-knockdown by p27 RNAi. However, both p27 and p25 are not required for 19S dynactin complex integrity verified by velocity sedimentation. p27/DCTN6 and other dynactin pointed-end complex subunits (Arp11/Actr10, p62/DCTN4, and p25/DCTN5) have been suggested to be involved in dynactin binding to specific intracellular cargoes. Co-depletion of dynactin p27 and p25 by p27 RNAi affects dynactin binding to endomembrane, and early and recycling endosome movements are impaired, suggesting that p27/p25 form a selective endomembrane cargo-targeting module.In mitosis, unlike dynactin or dynein perturbation that causes mitotic spindle disarrangement and mitotic arrest, dynactin p27/p25 depletion are does not affect mitotic spindle formation, pole focusing or dynein/dynactin targeting to kinetochores. However, dynactin p27/p25 are required for normal chromosome alignment, kinetochore-microtubule interaction, and proper timing of anaphase onset. Dynactin p27 C-terminal T186 residue is phosphorylated by cyclin-dependent kinase 1 (Cdk1) in mitosis and helps target polo-like kinase 1 (Plk1) to kinetochores during prometaphase. This activity facilitates phosphorylation of important downstream kinetochore targets (such as tension-sensing 3F3/2 phospho-epitope) of Plk1, which is important for recruitment of spindle assembly checkpoint proteins such as Mad1 and proper kinetochore-microtubule attachment. X-ray crystal structure revealed that dynactin p27 forms an unusual left handed β-helix (LβH) domain, and its phosphorylation site T186 is in C-terminal disordered segment.".
- DCTN6 wikiPageID "39110947".
- DCTN6 wikiPageLength "4531".
- DCTN6 wikiPageOutDegree "21".
- DCTN6 wikiPageRevisionID "617214922".
- DCTN6 wikiPageWikiLink Actr10.
- DCTN6 wikiPageWikiLink Category:Eukaryote_genes.
- DCTN6 wikiPageWikiLink Category:Motor_proteins.
- DCTN6 wikiPageWikiLink Cdk1.
- DCTN6 wikiPageWikiLink Chromosome.
- DCTN6 wikiPageWikiLink Cyclin-dependent_kinase_1.
- DCTN6 wikiPageWikiLink Cytoplasmic_dynein.
- DCTN6 wikiPageWikiLink DCTN4.
- DCTN6 wikiPageWikiLink DCTN5.
- DCTN6 wikiPageWikiLink Dynactin.
- DCTN6 wikiPageWikiLink Dynein.
- DCTN6 wikiPageWikiLink Endosome.
- DCTN6 wikiPageWikiLink Kinetochore.
- DCTN6 wikiPageWikiLink Mad1.
- DCTN6 wikiPageWikiLink Microtubule.
- DCTN6 wikiPageWikiLink Mitosis.
- DCTN6 wikiPageWikiLink Mitotic_spindle.
- DCTN6 wikiPageWikiLink PLK1.
- DCTN6 wikiPageWikiLink Plk1.
- DCTN6 wikiPageWikiLink Polo-like_kinase_1.
- DCTN6 wikiPageWikiLink Prometaphase.
- DCTN6 wikiPageWikiLink Spindle_apparatus.
- DCTN6 wikiPageWikiLinkText "DCTN6".
- DCTN6 hasPhotoCollection DCTN6.
- DCTN6 wikiPageUsesTemplate Template:Multiple_issues.
- DCTN6 wikiPageUsesTemplate Template:Reflist.
- DCTN6 subject Category:Eukaryote_genes.
- DCTN6 subject Category:Motor_proteins.
- DCTN6 hypernym Gene.
- DCTN6 type Article.
- DCTN6 type Protein.
- DCTN6 type Article.
- DCTN6 type Machine.
- DCTN6 type Page.
- DCTN6 comment "DCTN6 is the gene of p27 subunit of the dynactin complex, which is the essential component for microtubule-based cytoplasmic dynein motor activity in transport of variety of intracellular cargoes and organelle. It is first identified and cloned as a subunit of the "pointed-end complex" of dynactin through biochemical purification.".
- DCTN6 label "DCTN6".
- DCTN6 sameAs m.0t53b7k.
- DCTN6 sameAs Q17008587.
- DCTN6 sameAs Q17008587.
- DCTN6 wasDerivedFrom DCTN6?oldid=617214922.
- DCTN6 isPrimaryTopicOf DCTN6.