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- DCPS_(gene) abstract "Scavenger mRNA-decapping enzyme DcpS is a protein that in humans is encoded by the DCPS gene.The scavenger mRNA decapping enzymes include Dcp2 and DcpS. DcpS is a scavenger pyrophosphatase that hydrolyses the residual cap structure following 3' to 5' mRNA degradation. DcpS uses cap dinucleotides or capped oligonucleotides as substrates to release m(7)GMP (N7-methyl GMP), while Dcp2 uses capped mRNA as a substrate in order to hydrolyse the cap to release m(7)GDP (N7-methyl GDP). The association of DcpS with 3' to 5' exonuclease exosome components suggests that these two activities are linked and there is a coupled exonucleolytic decay-dependent decapping pathway. The family contains a histidine triad (HIT) sequence in its C-terminal domain, with three histidines separated by hydrophobic residues. The central histidine within the DcpS HIT motif is critical for decapping activity and defines the HIT motif as a new mRNA decapping domain, making DcpS the first member of the HIT family of proteins with a defined biological function.".
- DCPS_(gene) entrezgene "28960".
- DCPS_(gene) symbol "DcpS".
- DCPS_(gene) symbol "DcpS_C".
- DCPS_(gene) thumbnail PDB_1vlr_EBI.jpg?width=300.
- DCPS_(gene) wikiPageID "14877613".
- DCPS_(gene) wikiPageLength "10542".
- DCPS_(gene) wikiPageOutDegree "23".
- DCPS_(gene) wikiPageRevisionID "673182729".
- DCPS_(gene) wikiPageWikiLink 5_cap.
- DCPS_(gene) wikiPageWikiLink Biology.
- DCPS_(gene) wikiPageWikiLink Category:Protein_families.
- DCPS_(gene) wikiPageWikiLink Dinucleotide.
- DCPS_(gene) wikiPageWikiLink Directionality_(molecular_biology).
- DCPS_(gene) wikiPageWikiLink Enzyme_substrate.
- DCPS_(gene) wikiPageWikiLink Exonuclease.
- DCPS_(gene) wikiPageWikiLink Exosome_complex.
- DCPS_(gene) wikiPageWikiLink Five-prime_cap.
- DCPS_(gene) wikiPageWikiLink Gene.
- DCPS_(gene) wikiPageWikiLink Histidine.
- DCPS_(gene) wikiPageWikiLink Histidines.
- DCPS_(gene) wikiPageWikiLink Hydrolyse.
- DCPS_(gene) wikiPageWikiLink Hydrolysis.
- DCPS_(gene) wikiPageWikiLink Hydrophobe.
- DCPS_(gene) wikiPageWikiLink Hydrophobic.
- DCPS_(gene) wikiPageWikiLink MRNA.
- DCPS_(gene) wikiPageWikiLink Messenger_RNA.
- DCPS_(gene) wikiPageWikiLink Nucleotide.
- DCPS_(gene) wikiPageWikiLink Oligonucleotide.
- DCPS_(gene) wikiPageWikiLink Oligonucleotides.
- DCPS_(gene) wikiPageWikiLink Protein.
- DCPS_(gene) wikiPageWikiLink Protein_family.
- DCPS_(gene) wikiPageWikiLink Protein_motif.
- DCPS_(gene) wikiPageWikiLink Pyrophosphatase.
- DCPS_(gene) wikiPageWikiLink Residue_(chemistry).
- DCPS_(gene) wikiPageWikiLink Sequence_(biology).
- DCPS_(gene) wikiPageWikiLink Sequence_motif.
- DCPS_(gene) wikiPageWikiLink Structural_motif.
- DCPS_(gene) wikiPageWikiLink Substrate_(chemistry).
- DCPS_(gene) wikiPageWikiLinkText "DCPS (gene)".
- DCPS_(gene) caption "crystal structure of mrna decapping enzyme from mus musculus at 1.83 a resolution".
- DCPS_(gene) hasPhotoCollection DCPS_(gene).
- DCPS_(gene) interpro "IPR008594".
- DCPS_(gene) name "Scavenger mRNA decapping enzyme N-terminal".
- DCPS_(gene) name "Scavenger mRNA decapping enzyme C-term binding".
- DCPS_(gene) pfam "PF05652".
- DCPS_(gene) pfam "PF11969".
- DCPS_(gene) pfamClan "CL0265".
- DCPS_(gene) requireManualInspection "no".
- DCPS_(gene) scop "1".
- DCPS_(gene) symbol "DcpS".
- DCPS_(gene) symbol "DcpS_C".
- DCPS_(gene) updateCitations "yes".
- DCPS_(gene) updatePage "yes".
- DCPS_(gene) updateProteinBox "yes".
- DCPS_(gene) updateSummary "yes".
- DCPS_(gene) wikiPageUsesTemplate Template:Gene-11-stub.
- DCPS_(gene) wikiPageUsesTemplate Template:Infobox_protein_family.
- DCPS_(gene) wikiPageUsesTemplate Template:InterPro_content.
- DCPS_(gene) wikiPageUsesTemplate Template:PBB.
- DCPS_(gene) wikiPageUsesTemplate Template:PBB_Controls.
- DCPS_(gene) wikiPageUsesTemplate Template:PBB_Further_reading.
- DCPS_(gene) wikiPageUsesTemplate Template:PBB_Summary.
- DCPS_(gene) wikiPageUsesTemplate Template:PDB_Gallery.
- DCPS_(gene) wikiPageUsesTemplate Template:Refbegin.
- DCPS_(gene) wikiPageUsesTemplate Template:Refend.
- DCPS_(gene) wikiPageUsesTemplate Template:Reflist.
- DCPS_(gene) subject Category:Protein_families.
- DCPS_(gene) hypernym Protein.
- DCPS_(gene) type Biomolecule.
- DCPS_(gene) type Protein.
- DCPS_(gene) type Thing.
- DCPS_(gene) type Q206229.
- DCPS_(gene) type Q8054.
- DCPS_(gene) comment "Scavenger mRNA-decapping enzyme DcpS is a protein that in humans is encoded by the DCPS gene.The scavenger mRNA decapping enzymes include Dcp2 and DcpS. DcpS is a scavenger pyrophosphatase that hydrolyses the residual cap structure following 3' to 5' mRNA degradation. DcpS uses cap dinucleotides or capped oligonucleotides as substrates to release m(7)GMP (N7-methyl GMP), while Dcp2 uses capped mRNA as a substrate in order to hydrolyse the cap to release m(7)GDP (N7-methyl GDP).".
- DCPS_(gene) label "DCPS (gene)".
- DCPS_(gene) sameAs m.03g_zx6.
- DCPS_(gene) sameAs Q5204540.
- DCPS_(gene) sameAs Q5204540.
- DCPS_(gene) wasDerivedFrom DCPS_(gene)?oldid=673182729.
- DCPS_(gene) depiction PDB_1vlr_EBI.jpg.
- DCPS_(gene) isPrimaryTopicOf DCPS_(gene).